ChemInform Abstract: Suppression of Nitric Oxide Production on LPS/IFN-γ-Stimulated RAW264.7 Macrophages by a Novel Catechin, Pilosanol N, from Agrimonia pilosa Ledeb.

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Wakana Ohmine ◽  
Takayuki Ogi ◽  
Hitoshi Nanbu ◽  
Katsuhiro Ueda
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We studied the actions of glycyrrhizin on nitric oxide production from macrophages and a macrophage cell line RA W264-7. Although glycyrrhizin did not induce nitric oxide from resting macrophages, it enhanced the production of nitric oxide from IFN-γ activated-macrophages or RA W cells. Glycyrrhizin also enhanced the production of nitric oxide from macrophages stimulated with the supernatant of con A-activated spleen cells. Further, glycyrrhizin enhanced tumor cell killing by macrophages activated with IFN-γ. This tumor cell killing was mainly by nitric oxide.


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