ChemInform Abstract: Structure-Activity Relationships of Biflavonoids for β-Secretase (BACE-1) Inhibitory Activity.

ChemInform ◽  
2013 ◽  
Vol 44 (11) ◽  
pp. no-no
Author(s):  
Hiroaki Sasaki ◽  
Yuki Kitoh ◽  
Kazuhiko Miki ◽  
Kaoru Kinoshita ◽  
Kiyotaka Koyama ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Abstract Structure ◽  
Bace 1

Structure-Activity Relationships of Biflavonoids for β-Secretase (BACE-1) Inhibitory Activity

Heterocycles ◽  
2012 ◽  
Vol 85 (11) ◽  
pp. 2749 ◽  
Author(s):  
Kunio Takahashi ◽  
Hiroaki Sasaki ◽  
Yuki Kitoh ◽  
Kazuhiko Miki ◽  
Kaoru Kinoshita ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Bace 1

ChemInform Abstract: Structure-Activity Relationships for Analogues of the Phenazine-Based Dual Topoisomerase I/II Inhibitor XR11576.

ChemInform ◽  
2010 ◽  
Vol 33 (24) ◽  
pp. no-no
Author(s):  
Shouming Wang ◽  
Warren Miller ◽  
John Milton ◽  
Nigel Vicker ◽  
Alistair Stewart ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Abstract Structure

ChemInform Abstract: Structure-Activity Relationships of trans-3,5-Disubstituted Pyrrolidinylthio-1β-methylcarbapenems. Part 1. J-111,347 and Related Compounds.

ChemInform ◽  
2010 ◽  
Vol 31 (20) ◽  
pp. no-no
Author(s):  
Hideaki Imamura ◽  
Norikazu Ohtake ◽  
Aya Shimizu ◽  
Hideki Jona ◽  
Hiroki Sato ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity ◽  
Abstract Structure ◽  
Related Compounds

Structure-activity relationships in the Hill inhibitory activity of substituted phenylureas

1987 ◽  
Vol 35 (4) ◽  
pp. 479-483 ◽  
Author(s):  
Patrick Camilleri ◽  
John R. Bowyer ◽  
Terence Gilkerson ◽  
Barbara Odell ◽  
Roger C. Weaver
Keyword(s):  
Inhibitory Activity ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
The Hill

ChemInform Abstract: Structure-Activity Relationships of N-Hydroxyurea 5-Lipoxygenase Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 28 (40) ◽  
pp. no-no
Author(s):  
A. O. STEWART ◽  
P. A. BHATIA ◽  
J. G. MARTIN ◽  
J. B. SUMMERS ◽  
K. E. RODRIQUES ◽  
...  
Keyword(s):  
Lipoxygenase Inhibitors ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Abstract Structure

ChemInform Abstract: Structure-Activity Relationships of 1,3-Benzoxazole-4-carbonitriles as Novel Antifungal Agents with Potent in vivo Efficacy.

ChemInform ◽  
2011 ◽  
Vol 42 (35) ◽  
pp. no-no
Author(s):  
Jun-ichi Kuroyanagi ◽  
Kazuo Kanai ◽  
Takao Horiuchi ◽  
Hiroshi Takeshita ◽  
Shozo Kobayashi ◽  
...  
Keyword(s):  
Antifungal Agents ◽  
In Vivo Efficacy ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Abstract Structure

scholarly journals Characterization of platinum(II) complexes exhibiting inhibitory activity against the 20S proteasome

2020 ◽  
Vol 7 (8) ◽  
pp. 200545
Author(s):  
Tatsuto Kiwada ◽  
Hiromu Katakasu ◽  
Serina Okumura ◽  
Akira Odani
Keyword(s):  
Inhibitory Activity ◽  
Chemical Structure ◽  
Competitive Inhibition ◽  
Proteasome Inhibitors ◽  
Platinum Complex ◽  
Platinum Complexes ◽  
Binding Mode ◽  
Structure Activity Relationships ◽  
Structure Activity

Proteasome inhibitors are useful for biochemical research and clinical treatment. In our previous study, we reported that the 4N-coordinated platinum complexes with anthracenyl ring and heterocycle exhibited proteasome-inhibitory activity. In the present study, the structure–activity relationships and characterization of these complexes were determined for the elucidation of the role of aromatic ligands. Lineweaver–Burk analysis revealed that the chemical structure of heterocycles affects the binding mode of platinum complexes. Platinum complexes with anthracenyl ring and pyridine showed competitive inhibition, although platinum complexes with anthracenyl ring and phenanthroline showed non-competitive inhibition. The structure–activity relationships demonstrated that anthracenyl moiety plays a crucial role in proteasome-inhibitory activity. The platinum complexes with naphthyl or phenyl rings exhibited lower inhibitory activities than the platinum complex with anthracenyl ring. The reactivity with N-acetylcysteine varied according to the chemical structure of complexes.

scholarly journals 5'-Nucleotidase inhibitory activity of nucleoticidin, melanocidin A and melanocidin B. Structure-activity relationships.

1985 ◽  
Vol 38 (11) ◽  
pp. 1564-1567 ◽  
Author(s):  
KEIJIRO UCHINO ◽  
HIROSHI OGAWARA ◽  
TETSU AKIYAMA ◽  
AKIRA FUKUCHI
Keyword(s):  
Inhibitory Activity ◽  
Structure Activity Relationships ◽  
Structure Activity
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