ChemInform Abstract: Synthesis of Sulfones from Organozinc Reagents, DABSO, and Alkyl Halides.

ChemInform ◽  
2014 ◽  
Vol 45 (23) ◽  
pp. no-no
Author(s):  
Benjamin N. Rocke ◽  
Kevin B. Bahnck ◽  
Michael Herr ◽  
Sophie Lavergne ◽  
Vincent Mascitti ◽  
...  
Keyword(s):  
Alkyl Halides ◽  
Organozinc Reagents

Synthesis of Sulfones from Organozinc Reagents, DABSO, and Alkyl Halides

2013 ◽  
Vol 16 (1) ◽  
pp. 154-157 ◽  
Author(s):  
Benjamin N. Rocke ◽  
Kevin B. Bahnck ◽  
Michael Herr ◽  
Sophie Lavergne ◽  
Vincent Mascitti ◽  
...  
Keyword(s):  
Alkyl Halides ◽  
Organozinc Reagents

Photoredox Activation of Organozinc Reagents: Barbier-Type Reaction of Alkyl Halides with α-(Trifluoromethyl)styrenes

2021 ◽  
Author(s):  
Anton A. Gladkov ◽  
Grigory N. Chernov ◽  
Vitalij V. Levin ◽  
Vladimir A. Kokorekin ◽  
Alexander D. Dilman
Keyword(s):  
Alkyl Halides ◽  
Type Reaction ◽  
Organozinc Reagents

Vitamin B12-based elimination of alkyl halides

2020 ◽  
Author(s):  
Julian West ◽  
Alexandros S Pollatos ◽  
Radha Bam
Keyword(s):  
Vitamin B12 ◽  
Alkyl Halides

Fe-Catalyzed Conjunctive Cross-Couplings of Unactivated Alkenes with Grignard Reagents

2020 ◽  
Author(s):  
Lei Liu ◽  
Wes Lee ◽  
Cassandra R. Youshaw ◽  
Mingbin Yuan ◽  
Michael B. Geherty ◽  
...  
Keyword(s):  
Functional Groups ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Turnover Frequency ◽  
Diverse Range ◽  
Cascade Cyclization ◽  
Radical Cascade

The first iron-catalyzed three-component cross-coupling of unactivated olefins with alkyl halides and Grignard reagents is reported. The reaction operates under fast turnover frequency and tolerates a diverse range of sp2-hybridized nucleophiles, alkyl halides, and unactivated olefins bearing diverse functional groups to yield the desired 1,2-alkylarylated products with high regiocontrol. Further, we demonstrate that this protocol is amenable for the synthesis of new (hetero)carbocycles including tetrahydrofurans and pyrrolidines via a three-component radical cascade cyclization/arylation that forges three new C-C bonds.

Design and Development of Fe-Catalyzed Intra- and Intermolecular Carbofunctionalization of Vinyl Cyclopropanes

2019 ◽  
Author(s):  
Lei Liu ◽  
Wes Lee ◽  
Mingbin Yuan ◽  
Chris Acha ◽  
Michael B. Geherty ◽  
...  
Keyword(s):  
Bond Formation ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Mechanistic Studies ◽  
Radical Intermediates ◽  
Design And Implementation ◽  
Solvent Cage ◽  
Radical Cascade ◽  
Radical Processes

Design and implementation of the first (asymmetric) Fe-catalyzed intra- and intermolecular difunctionalization of vinyl cyclopropanes (VCPs) with alkyl halides and aryl Grignard reagents has been realized via a mechanistically driven approach. Mechanistic studies support the diffusion of the alkyl radical intermediates out of the solvent cage to participate in an intra- or -intermolecular radical cascade with the VCP followed by re-entering the Fe radical cross-coupling cycle to undergo selective C(sp2)-C(sp3) bond formation. Overall, we provide new design principles for Fe-mediated radical processes and underscore the potential of using combined computations and experiments to accelerate the development of challenging transformations.

Nickel and Cobalt-Catalyzed Coupling of Alkyl Halides with Alkenes via Heck Reactions and Radical Conjugate Addition

2013 ◽  
Vol 13 (6) ◽  
pp. 802-813 ◽  
Author(s):  
Qun Qian ◽  
Zhenhua Zang ◽  
Yang Chen ◽  
Weiqi Tong ◽  
Hegui Gong
Keyword(s):  
Conjugate Addition ◽  
Alkyl Halides ◽  
Heck Reactions

Nickel-Catalyzed Multicomponent Coupling Reaction of Alkyl Halides, Isocyanides and H2O: An Expedient Way to Access Alkyl Amides

Synthesis ◽  
2020 ◽  
Vol 52 (22) ◽  
pp. 3466-3472
Author(s):  
Yunkui Liu ◽  
Bingwei Zhou ◽  
Qiao Li ◽  
Hongwei Jin
Keyword(s):  
Functional Group ◽  
Coupling Reaction ◽  
Alkyl Halides ◽  
Previous Literature ◽  
Catalytic Cycle ◽  
Reaction Conditions ◽  
Multicomponent Coupling ◽  
Easy Operation

We herein describe a Ni-catalyzed multicomponent coupling reaction of alkyl halides, isocyanides, and H2O to access alkyl amides. Bench-stable NiCl2(dppp) is competent to initiate this transformation under mild reaction conditions, thus allowing easy operation and adding practical value. Substrate scope studies revealed a broad functional group tolerance and generality of primary and secondary alkyl halides in this protocol. A plausible catalytic cycle via a SET process is proposed based on preliminary experiments and previous literature.

A novel ketone synthesis by a palladium-catalyzed reaction of thiol esters and organozinc reagents

1998 ◽  
Vol 39 (20) ◽  
pp. 3189-3192 ◽  
Author(s):  
Hidetoshi Tokuyama ◽  
Satoshi Yokoshima ◽  
Tohru Yamashita ◽  
Tohru Fukuyama
Keyword(s):  
Thiol Esters ◽  
Palladium Catalyzed ◽  
Organozinc Reagents

Facile reaction of o-carboranyllithium reagents with functionalized alkyl halides

1996 ◽  
Vol 37 (19) ◽  
pp. 3383-3386 ◽  
Author(s):  
Jianping Cai ◽  
Hiaso Nemoto ◽  
Bakthan Singaram ◽  
Yoshinori Yamamoto
Keyword(s):  
Alkyl Halides
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