One-pot syntheses are a simple, efficient and easy methodology, which are widely
used for the synthesis of organic compounds. Imidazoline is a valuable heterocyclic moiety
used as a synthetic intermediate, chiral auxiliary, chiral catalyst and a ligand for asymmetric
catalysis. Imidazole is a fundamental unit of biomolecules that can be easily prepared from
imidazolines. The one-pot method is an impressive approach to synthesize organic compounds
as it minimizes the reaction time, separation procedures, and ecological impact. Many significant
one-pot methods such as N-bromosuccinimide mediated reaction, ring-opening of tetrahydrofuran,
triflic anhydrate mediated reaction, etc. were reported for imidazoline synthesis.
This review describes an overview of the one-pot synthesis of imidazolines and covers literature
up to 2020.
An efficient and green protocol for the one-pot synthesis of 3-amido-alkyl-4-hydroxycoumarin derivatives by choline chloride/urea as a deep eutectic solvent