Novel highly efficient absolute optical resolution method by serial combination of two asymmetric reactions from acetylene monomers having racemic substituents

Chirality ◽  
2022 ◽  
Author(s):  
Yanan Tang ◽  
Lijia Liu ◽  
Junpei Suzuki ◽  
Masahiro Teraguchi ◽  
Takashi Kaneko ◽  
...  
Keyword(s):  
Optical Resolution ◽  
Asymmetric Reactions ◽  
Resolution Method ◽  
Highly Efficient

New Optical Resolution Method for Racemic DL-Aspartic Acid by Crystallization in the Presence of d- or l-Asparagine as a Tailor-Made Additive

2015 ◽  
Vol 48 (11) ◽  
pp. 903-908 ◽  
Author(s):  
Hiroyasu Sato ◽  
Norihito Doki ◽  
Masaaki Yokota ◽  
Kenji Shimizu ◽  
Shingo Yano
Keyword(s):  
Aspartic Acid ◽  
Optical Resolution ◽  
Resolution Method

Recent applications of chiral N-tert-butanesulfinyl imines, chiral diene ligands and chiral sulfur–olefin ligands in asymmetric synthesis

2015 ◽  
Vol 2 (1) ◽  
pp. 73-89 ◽  
Author(s):  
Han-Qing Dong ◽  
Ming-Hua Xu ◽  
Chen-Guo Feng ◽  
Xing-Wen Sun ◽  
Guo-Qiang Lin
Keyword(s):  
Asymmetric Synthesis ◽  
Asymmetric Reactions ◽  
Highly Efficient ◽  
Diene Ligands

The highly efficient asymmetric reactions of chiral sulfinyl auxiliary, diene ligands and sulfur–olefin ligands are presented.

ChemInform Abstract: New Preparative and Optical Resolution Method for β-Lactams.

ChemInform ◽  
1990 ◽  
Vol 21 (32) ◽  
Author(s):  
F. TODA ◽  
K. TANAKA ◽  
M. YAGI ◽  
Z. STEIN ◽  
I. GOLDBERG
Keyword(s):  
Optical Resolution ◽  
Resolution Method

scholarly journals Gas Antisolvent Fractionation: A New Approach for the Optical Resolution of 4-chloromandelic Acid

2019 ◽  
Vol 63 (2) ◽  
pp. 303-311
Author(s):  
Amit Zodge ◽  
Márton Kőrösi ◽  
János Madarász ◽  
Imre Miklós Szilágyi ◽  
Erzsébet Varga ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Organic Solvent ◽  
Enantiomeric Excess ◽  
Optical Resolution ◽  
Operational Parameters ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Resolution Method ◽  
New Approach ◽  
Gas Antisolvent

A new, rapid optical resolution method of 4-chloromandelic acid is presented using (R)-1-phenylethanamine as the resolving agent. Gas antisolvent fractionation was investigated as the separation method, studying the effect of pressure, temperature and carbon dioxide to organic solvent mass ratio in details. Generally, the method offers green operation using supercritical carbon dioxide as the precipitative agent, and can be less time- and organic solvent-intensive than conventional processes. By upscaling, the possibility of controlling the crystal-morphology might also be improved. At 16 MPa, 40 °C and 7.5 carbon dioxide to methanol ratio 72 % enantiomeric excess was reached in the crystalline product, along a 73 % yield. The resolution efficiency was not affected by any of the operational parameters. Enantiomeric enrichment beyond 90 % can be carried out by repeated resolution of a scalemic mixture of the acid. Solid products were investigated using differential scanning calorimetry, powder X-ray diffraction and scanning electron microscopy confirming the formation of a crystalline (R)-1-phenylethanammonium-4-chloromandelate salt.

New preparative and optical resolution method for β-lactams

1990 ◽  
pp. 1215-1216 ◽  
Author(s):  
Fumio Toda ◽  
Koichi Tanaka ◽  
Minoru Yagi ◽  
Zafra Stein ◽  
Israel Goldberg
Keyword(s):  
Optical Resolution ◽  
Resolution Method
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