Stereoselective michael addition and michael-aldol tandem reaction of diorganyl diselenides or disulfides with conjugated alkynones mediated by samarium diiodide

2010 ◽  
Vol 22 (9) ◽  
pp. 958-965 ◽  
Author(s):  
Xing-Liang Zheng ◽  
Xiao-Liang Xu ◽  
Yong-Min Zhang
Keyword(s):  
Michael Addition ◽  
Tandem Reaction ◽  
Samarium Diiodide

Practical Synthesis of Functionalized Chromeno[3,4-c]pyridine Derivatives via a CuCl2-Catalyzed Tandem Reaction of the Blaise Reaction Intermediates and 3-Cyanocoumarins

Synlett ◽  
2018 ◽  
Vol 29 (07) ◽  
pp. 959-963
Author(s):  
Jian-Jun Li ◽  
Zhiwei Chen ◽  
Yangyang Fan ◽  
Lei Zheng ◽  
Zhaohai Yang
Keyword(s):  
Michael Addition ◽  
Functional Group ◽  
Tandem Reaction ◽  
Pyridine Derivatives ◽  
Reaction Intermediates ◽  
Reaction Conditions ◽  
Purification Technique ◽  
Aromatization Reaction ◽  
Oxidative Aromatization ◽  
Practical Synthesis

This work discloses a novel and efficient protocol for the construction of functionalized chromeno[3,4-c]pyridine derivatives from the Blaise reaction intermediates and 3-cyanocoumarins through a CuCl2-catalyzed sequential Michael addition/intramolecular cyclization/oxidative aromatization reaction. This new method shows the advantages of mild reaction conditions, easy workup, nonchromatographic purification technique, good functional group tolerance, and moderate to good yields.

Stereoselective synthesis of organosulfur compounds incorporating N-aromatic heterocyclic motifs and quaternary carbon centers via a sulfa-Michael triggered tandem reaction

2015 ◽  
Vol 51 (47) ◽  
pp. 9714-9717 ◽  
Author(s):  
Tianyou Qin ◽  
Lu Cheng ◽  
Sean Xiao-An Zhang ◽  
Weiwei Liao
Keyword(s):  
Michael Addition ◽  
Stereoselective Synthesis ◽  
Tandem Reaction ◽  
Organosulfur Compounds ◽  
The Novel ◽  
Quaternary Carbon ◽  
Carbon Centers ◽  
Aromatic Heterocyclic

The novel sulfa-Michael addition (SMA)-triggered tandem reaction was developed by combining a SMA reaction with a simultaneous rearomatization process.

A controlled selective synthesis of dihydropyrans through tandem reaction of alkynes with diazo compounds

2017 ◽  
Vol 53 (31) ◽  
pp. 4350-4353 ◽  
Author(s):  
Junxiang Min ◽  
Guangyang Xu ◽  
Jiangtao Sun
Keyword(s):  
Michael Addition ◽  
Diazo Compounds ◽  
Tandem Reaction ◽  
Controlled Synthesis ◽  
Selective Synthesis ◽  
Sequential Reaction

A controlled synthesis of dihydropyrans via sequential reaction of allenoate formation and intramolecular oxo-Michael addition has been achieved.

Metal-free oxidative coupling of aminopyridines with nitroolefins to imidazo[1,2-a]pyridine in the presence of I2–TBHP–pyridine

2016 ◽  
Vol 71 (2) ◽  
pp. 141-147 ◽  
Author(s):  
Litao An ◽  
Xiaojun Sun ◽  
Meng Lv ◽  
Jianfeng Zhou ◽  
Fengxia Zhu ◽  
...  
Keyword(s):  
Catalytic System ◽  
Michael Addition ◽  
Oxidative Coupling ◽  
Tandem Reaction ◽  
Butyl Hydroperoxide ◽  
Metal Free

AbstractA facile metal-free approach to the synthesis of imidazo[1,2-a]pyridine was developed through a tandem reaction of Michael addition and oxidative coupling. Iodine–t-butyl hydroperoxide–pyridine was found to be a green and efficient catalytic system for this approach.

Phosphine catalyzed [3+2] cyclization/Michael addition of allenoate with CS2 to form 2-thineyl vinyl sulfide

2020 ◽  
Vol 56 (78) ◽  
pp. 11669-11672
Author(s):  
Weihong Fei ◽  
Ping Xu ◽  
Jie Hou ◽  
Weijun Yao
Keyword(s):  
Michael Addition ◽  
Tandem Reaction ◽  
Vinyl Sulfide ◽  
Two Component

We have developed a DPPE-catalyzed three molecular two component tandem reaction of γ-substituted allenoate and CS2 to construct 2-thineyl vinyl sulfide through phosphine catalyzed [3+2] cyclization followed by Michael addition.

A Brønsted acid catalyzed tandem reaction for the diastereoselective synthesis of cyclobuta-fused tetrahydroquinoline carboxylic esters

2021 ◽  
Author(s):  
Valentina Marras ◽  
Pierluigi Caboni ◽  
Francesco Secci ◽  
Régis Guillot ◽  
David J. Aitken ◽  
...  
Keyword(s):  
Michael Addition ◽  
Tandem Reaction ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Diastereoselective Synthesis ◽  
Cyclization Process ◽  
Brönsted Acid ◽  
Acid Catalyzed ◽  
Carboxylic Esters

We have established a Brønsted acid catalyzed diastereoselective synthesis of diversely substituted cyclobuta-fused tetrahydroquinoline carboxylic esters through a new tandem aza-Michael addition-aza-Friedel–Crafts cyclization process.

scholarly journals Catalytic asymmetric tandem Friedel–Crafts alkylation/Michael addition reaction for the synthesis of highly functionalized chromans

2013 ◽  
Vol 9 ◽  
pp. 1210-1216 ◽  
Author(s):  
Jiahuan Peng ◽  
Da-Ming Du
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Tandem Reaction ◽  
Michael Addition Reaction ◽  
Catalytic Asymmetric

The enantioselective tandem Friedel–Crafts alkylation/Michael addition reaction of indoles with nitroolefin enoates catalyzed by a diphenylamine-linked bis(oxazoline)-Zn(OTf)2 complex was investigated. This tandem reaction afforded functionalized chiral chromans in good yields with moderate to high stereoselectivities (up to 95:5 dr, up to 99% ee).

Diastereoselective synthesis ofcis-1,3-disubstituted isoindolinesviaa highly site-selective tandem cyclization reaction

2018 ◽  
Vol 5 (12) ◽  
pp. 1950-1956 ◽  
Author(s):  
Siyang Xing ◽  
Hong Cui ◽  
Jiajing Qin ◽  
Nan Gu ◽  
Bowei Zhang ◽  
...  
Keyword(s):  
Michael Addition ◽  
Ring Opening ◽  
Cyclization Reaction ◽  
Tandem Reaction ◽  
Diastereoselective Synthesis ◽  
Tandem Cyclization ◽  
Site Selective

A highly site-selective tandem reaction involving regioselective ring opening of aziridines and Michael addition of electron-deficient alkenes has been described.

Diastereoselective access to 2-aminoindanones via the rhodium(ii)-catalyzed tandem reaction involving O–H insertion and Michael addition

2019 ◽  
Vol 6 (17) ◽  
pp. 3121-3126
Author(s):  
Siyang Xing ◽  
Hanyu Xia ◽  
Xin Wang ◽  
Die Wu ◽  
Xinrui Xu ◽  
...  
Keyword(s):  
Michael Addition ◽  
Tandem Reaction

A rhodium(ii)-catalyzed tandem reaction involving O–H insertion of N-sulfonyl 1,2,3-triazoles and Michael addition has been described. A series of 2-amino-1-indanones were afforded in acceptable to good yields with high diastereoselectivities.

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