A controlled selective synthesis of dihydropyrans through tandem reaction of alkynes with diazo compounds

2017 ◽  
Vol 53 (31) ◽  
pp. 4350-4353 ◽  
Author(s):  
Junxiang Min ◽  
Guangyang Xu ◽  
Jiangtao Sun
Keyword(s):  
Michael Addition ◽  
Diazo Compounds ◽  
Tandem Reaction ◽  
Controlled Synthesis ◽  
Selective Synthesis ◽  
Sequential Reaction

A controlled synthesis of dihydropyrans via sequential reaction of allenoate formation and intramolecular oxo-Michael addition has been achieved.

Catalytic Asymmetric Tandem Reaction of o-Alkynylbenzaldehydes, Amines, and Diazo Compounds

2021 ◽  
Author(s):  
Wei Wu ◽  
Na Liao ◽  
Qi Wei ◽  
Jiaying Huang ◽  
Qi Huang ◽  
...  
Keyword(s):  
Diazo Compounds ◽  
Tandem Reaction ◽  
Catalytic Asymmetric

Selective synthesis of acylated caprolactam via sequential Michael addition/palladium-catalyzed alpha-arylation of ketones

2021 ◽  
Author(s):  
Xin-Xing Wu ◽  
Hao Ye ◽  
Ming Li ◽  
Jianing Qian ◽  
Hong Dai ◽  
...  
Keyword(s):  
Michael Addition ◽  
Bond Formation ◽  
Selective Synthesis ◽  
Methyl Ketones ◽  
Rapid Access ◽  
Palladium Catalyzed ◽  
Efficient Route

A formal [6 + 1] annulation reaction provides an efficient route enabling rapid access to diverse caprolactams by the double C–C bond formation of the same site from methyl ketones.

ChemInform Abstract: Atom-Economical Access to Highly Substituted Indenes and Furan-2-ones via Tandem Reaction of Diazo Compounds and Propargyl Alcohols.

ChemInform ◽  
2015 ◽  
Vol 46 (7) ◽  
pp. no-no
Author(s):  
Sengodagounder Muthusamy ◽  
Manickasamy Sivaguru
Keyword(s):  
Diazo Compounds ◽  
Tandem Reaction ◽  
Propargyl Alcohols

Gold(III)-Catalyzed Tandem Reaction ofO-Arylhydroxylamines with 1,3-Dicarbonyl Compounds: Highly Selective Synthesis of 3-Carbonylated Benzofuran Derivatives

2010 ◽  
Vol 75 (18) ◽  
pp. 6300-6303 ◽  
Author(s):  
Yunkui Liu ◽  
Jianqiang Qian ◽  
Shaojie Lou ◽  
Zhenyuan Xu
Keyword(s):  
Tandem Reaction ◽  
Selective Synthesis ◽  
Dicarbonyl Compounds

Base-Mediated Tandem Reaction of α-Aryloxyacetophenones with Phosphonates: Selective Synthesis of Enol Phosphates

Synthesis ◽  
2012 ◽  
Vol 44 (07) ◽  
pp. 1119-1125
Author(s):  
Ye-Xiang Xie ◽  
Jin-Heng Li ◽  
Ren-Jie Song ◽  
Yan-Yun Liu ◽  
Ji-Cheng Wu ◽  
...  
Keyword(s):  
Tandem Reaction ◽  
Selective Synthesis

One-pot synthesis of 6,11-dihydro-5H-indolizino[8,7-b]indoles via sequential formation of β-enamino ester, Michael addition and Pictet–Spengler reactions

RSC Advances ◽  
2014 ◽  
Vol 4 (108) ◽  
pp. 62817-62826 ◽  
Author(s):  
Dan Zhu ◽  
Jing Sun ◽  
Chao-Guo Yan
Keyword(s):  
Michael Addition ◽  
One Pot ◽  
Sequential Reaction ◽  
One Pot Synthesis ◽  
Sequential Formation

One pot sequential reaction of generation of β-enamino ester, Michael addition and Pictet–Spengler reaction.

ChemInform Abstract: Copper-Catalyzed Tandem Reaction of 2-Haloaniline Derivatives with Tetraalkylthiuram Disulfides: Selective Synthesis of 2-Aminobenzothiazoles.

ChemInform ◽  
2010 ◽  
Vol 41 (12) ◽  
Author(s):  
Sha-Sha Pi ◽  
Xing-Guo Zhang ◽  
Ri-Yuan Tang ◽  
Jin-Heng Li
Keyword(s):  
Tandem Reaction ◽  
Selective Synthesis

Aziridinyl imines in organic synthesis: Development of tandem reaction strategies and application to total synthesis of natural products

2013 ◽  
Vol 85 (4) ◽  
pp. 741-753 ◽  
Author(s):  
Hee-Yoon Lee ◽  
Seog-Beom Song ◽  
Taek Kang ◽  
Yoon Jung Kim ◽  
Su Jeong Geum
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Organic Synthesis ◽  
Reactive Intermediates ◽  
Diazo Compounds ◽  
Tandem Reaction ◽  
Cycloaddition Reactions ◽  
Free Radical Reactions ◽  
Sulfur Ylide ◽  
Epoxide Formation

Aziridinyl imines are well-known carbene equivalents because they are precursors of diazo compounds from which reactive intermediates can be produced. These carbene equivalents can be utilized as zwitterionic species, diradicals, or 4π system for cycloaddition reactions. Thus, the intermediates derived from aziridinyl imines have been used in the sulfur-ylide-mediated epoxide formation, tandem free-radical reactions, or cyclopropanation reaction via carbene intermediates to form trimethylenemethane (TMM) diyls, which undergo [2 + 3] cycloaddition reactions to form cyclopentanoids. Diazo compounds generated from aziridinyl imines also react with allenes to form TMM diyls. This reaction was utilized in tandem cycloaddition reactions of linear substrates to form polyquinanes. These tandem reaction strategies were successfully applied to the total synthesis of various cyclopentanoid natural products.

Practical Synthesis of Functionalized Chromeno[3,4-c]pyridine Derivatives via a CuCl2-Catalyzed Tandem Reaction of the Blaise Reaction Intermediates and 3-Cyanocoumarins

Synlett ◽  
2018 ◽  
Vol 29 (07) ◽  
pp. 959-963
Author(s):  
Jian-Jun Li ◽  
Zhiwei Chen ◽  
Yangyang Fan ◽  
Lei Zheng ◽  
Zhaohai Yang
Keyword(s):  
Michael Addition ◽  
Functional Group ◽  
Tandem Reaction ◽  
Pyridine Derivatives ◽  
Reaction Intermediates ◽  
Reaction Conditions ◽  
Purification Technique ◽  
Aromatization Reaction ◽  
Oxidative Aromatization ◽  
Practical Synthesis

This work discloses a novel and efficient protocol for the construction of functionalized chromeno[3,4-c]pyridine derivatives from the Blaise reaction intermediates and 3-cyanocoumarins through a CuCl2-catalyzed sequential Michael addition/intramolecular cyclization/oxidative aromatization reaction. This new method shows the advantages of mild reaction conditions, easy workup, nonchromatographic purification technique, good functional group tolerance, and moderate to good yields.

Stereoselective synthesis of organosulfur compounds incorporating N-aromatic heterocyclic motifs and quaternary carbon centers via a sulfa-Michael triggered tandem reaction

2015 ◽  
Vol 51 (47) ◽  
pp. 9714-9717 ◽  
Author(s):  
Tianyou Qin ◽  
Lu Cheng ◽  
Sean Xiao-An Zhang ◽  
Weiwei Liao
Keyword(s):  
Michael Addition ◽  
Stereoselective Synthesis ◽  
Tandem Reaction ◽  
Organosulfur Compounds ◽  
The Novel ◽  
Quaternary Carbon ◽  
Carbon Centers ◽  
Aromatic Heterocyclic

The novel sulfa-Michael addition (SMA)-triggered tandem reaction was developed by combining a SMA reaction with a simultaneous rearomatization process.

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