Formation of Chiralα-Monofluorinated-β-amino Esters through Organocatalytic Asymmetric Reduction ofα-Fluoro-β-enamino Esters by Trichlorosilane

2012 ◽  
Vol 30 (11) ◽  
pp. 2636-2640 ◽  
Author(s):  
Peng Zhang ◽  
Chao Wang ◽  
Li Zhou ◽  
Jian Sun
Keyword(s):  
Asymmetric Reduction ◽  
Amino Esters

Chiral Phosphinyl Enamines and Their Asymmetric Reduction through Group-Assisted Purification Chemistry Leading to Enantiopure β-Amino Esters/Amides

Synlett ◽  
2017 ◽  
Vol 28 (18) ◽  
pp. 2483-2488 ◽  
Author(s):  
Bo Jiang ◽  
Guigen Li ◽  
Shuo Qiao ◽  
Jianbin Wu ◽  
Junming Mo ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Efficient Method ◽  
Asymmetric Reduction ◽  
Sodium Cyanoborohydride ◽  
Amino Esters

A series of new chiral N-phosphinyl β-enamino esters and amides were successfully prepared with excellent Z-stereoselectivity (Z/E > 99:1 in nearly all cases). Group-assisted purification chemistry proved to be an efficient method for the asymmetric reduction of the resulting β-enamino esters/amides to give enantiopure β-amino esters/amides. The asymmetric reduction can be controlled efficiently by using a combination of sodium cyanoborohydride and acetic acid.

SYNTHESIS OF CHIRAL DEPSIPEPTIDE BUILDING BLOCK BY THE ASYMMETRIC REDUCTION OFN-(α-KETOACYL)-α-AMINO ESTERS

1981 ◽  
Vol 10 (6) ◽  
pp. 823-826 ◽  
Author(s):  
Iwao Ojima ◽  
Toshiyuki Tanaka ◽  
Tetsuo Kogure
Keyword(s):  
Building Block ◽  
Asymmetric Reduction ◽  
Amino Esters

Exogenous Directing Group Free, Ligand-Enabled gamma-C(sp3)–H Arylation of Free Primary Aliphatic Amines and α-Amino Esters

2019 ◽  
Author(s):  
Yongzheng Ding ◽  
Shuai Fan ◽  
Xiaoxi Chen ◽  
yuzhen gao ◽  
Gang Li
Keyword(s):  
Amino Acids ◽  
Large Scale ◽  
Free Ligand ◽  
Aliphatic Amines ◽  
Rapid Synthesis ◽  
Amino Esters ◽  
Directing Group ◽  
Large Scale Synthesis ◽  
Primary Aliphatic Amines

A Pdᴵᴵ-catalyzed, ligand-enabled gamma-C(sp3)–H arylation of free primary aliphatic amines and amino esters without using an exogenous directing group is reported. This reaction is compatible with unhindered free aliphatic amines, and it is also be applicable to the rapid synthesis of biologically and synthetically valuable unnatural α-amino acids. Large scale synthesis is also feasible using this method.<br>

Screening and Identification of a Strain for Asymmetric Reduction of Ethyl Pyruvate

2012 ◽  
Vol 18 (3) ◽  
pp. 460
Author(s):  
Dan WANG ◽  
Wang LI ◽  
Chunfu GONG ◽  
Sijia YONG ◽  
Qiang ZHAGN ◽  
...  
Keyword(s):  
Ethyl Pyruvate ◽  
Asymmetric Reduction ◽  
Screening And Identification

Asymmetric reduction of a key intermediate of eslicarbazepine acetate using whole cell biotransformation in a biphasic medium

2012 ◽  
Vol 2 (8) ◽  
pp. 1602 ◽  
Author(s):  
Manpreet Singh ◽  
Sawraj Singh ◽  
Sateesh Deshaboina ◽  
Hare Krishnen ◽  
Richard Lloyd ◽  
...  
Keyword(s):  
Asymmetric Reduction ◽  
Eslicarbazepine Acetate ◽  
Whole Cell ◽  
Whole Cell Biotransformation ◽  
Biphasic Medium

ChemInform Abstract: OPTICAL SHIFT PMR SPECTROSCOPIC STUDIES ON SOME QUINOXALINE AMINO ESTERS AND DIPEPTIDES

1978 ◽  
Vol 9 (18) ◽  
Author(s):  
M. M. EL-ABADELAH ◽  
S. S. SABRI ◽  
H. D. TABBA ◽  
H. DUDDECK
Keyword(s):  
Spectroscopic Studies ◽  
Amino Esters
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