Acute and chronic heart failure: Diagnosis and therapy edited by wulf-dirk bussmann Springer-Verlag, Berlin (1986) 286 pages, illustrated, $80.00 ISBN: 0-387-15905-3

Natriuretic peptides including B-type natriuretic peptide (BNP), N-terminal (NT)-proBNP, and midregional pro-atrial natriuretic peptide (MR-proANP) are the biomarkers of choice in the diagnosis of heart failure. Assays measuring either BNP, NT-proBNP, or MR-proANP are widely available and run on large analysers operating in the central laboratory or as point-of-care options. Natriuretic peptides are considered quantitative markers of haemodynamic cardiac stress and therefore quantitative markers of heart failure itself. The clinical introduction of natriuretic peptides constitutes the most important advance in the diagnosis of heart failure in the last decade.

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Chronic heart failure diagnosis: biomarkers

ESC CardioMed ◽

10.1093/med/9780198784906.003.0409_update_001 ◽

2018 ◽

pp. 1778-1781

Author(s):

Christian Mueller

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Natriuretic Peptide ◽

Natriuretic Peptides ◽

Point Of Care ◽

Failure Diagnosis ◽

Central Laboratory ◽

Important Advance ◽

Cardiac Stress ◽

Heart Failure Diagnosis

Natriuretic peptides including B-type natriuretic peptide (BNP), N-terminal (NT)-proBNP, and midregional pro-atrial natriuretic peptide (MR-proANP) are the biomarkers of choice in the diagnosis of heart failure. Assays measuring either BNP, NT-proBNP, or MR-proANP are widely available and run on large analysers operating in the central laboratory or as point-of-care options. Natriuretic peptides are considered quantitative markers of haemodynamic cardiac stress and therefore quantitative markers of heart failure itself. The clinical introduction of natriuretic peptides constitutes the most important advance in the diagnosis of heart failure in the last decade.

Download Full-text

Chronic heart failure diagnosis: biomarkers

ESC CardioMed ◽

10.1093/med/9780198784906.003.0409 ◽

2018 ◽

pp. 1778-1781

Author(s):

Christian Mueller

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Natriuretic Peptide ◽

Natriuretic Peptides ◽

Point Of Care ◽

Failure Diagnosis ◽

Central Laboratory ◽

Important Advance ◽

Cardiac Stress ◽

Heart Failure Diagnosis

Natriuretic peptides including B-type natriuretic peptide (BNP), N-terminal (NT)-proBNP, and midregional pro-atrial natriuretic peptide (MR-proANP) are the biomarkers of choice in the diagnosis of heart failure. Assays measuring either BNP, NT-proBNP, or MR-proANP are widely available and run on large analysers operating in the central laboratory or as point-of-care options. Natriuretic peptides are considered quantitative markers of haemodynamic cardiac stress and therefore quantitative markers of heart failure itself. The clinical introduction of natriuretic peptides constitutes the most important advance in the diagnosis of heart failure in the last decade.

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High Intraindividual Variation of B-Type Natriuretic Peptide (BNP) and Amino-Terminal proBNP in Patients with Stable Chronic Heart Failure

Clinical Chemistry ◽

10.1373/clinchem.2004.038752 ◽

2004 ◽

Vol 50 (11) ◽

pp. 2052-2058 ◽

Cited By ~ 158

Author(s):

Sanne Bruins ◽

M Rebecca Fokkema ◽

Jeroen W P Römer ◽

Mike J L DeJongste ◽

Fey P L van der Dijs ◽

...

Keyword(s):

Heart Failure ◽

New York ◽

Chronic Heart Failure ◽

Natriuretic Peptide ◽

Heart Association ◽

Failure Diagnosis ◽

Treatment Optimization ◽

Intraindividual Variation ◽

Amino Terminal ◽

Heart Failure Diagnosis

Abstract Background: Plasma B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are promising markers for heart failure diagnosis, prognosis, and treatment. Insufficient data on the intraindividual biological variation (CVi) of BNP and NT-proBNP hamper interpretation of changes in concentration on disease progression or treatment optimization. We therefore investigated CVi values in stable heart failure patients. Methods: We recruited 43 patients with stable chronic heart failure living in Curaçao (22 males, 21 females; median age, 63 years; range, 20–86 years; New York Heart Association classes I–III). Samples were collected for within-day CVi (n = 6; every 2 h starting at 0800), day-to-day CVi (n = 5; samples collected between 0800 and 1000 on 5 consecutive days), and week-to-week CVi (n = 6; samples collected between 0800 and 1000 on the same day of the week for 6 consecutive weeks). NT-proBNP (Roche) and BNP (Abbott) were measured by immunoassay. Results: Median (range) concentrations were 134 (0–1630) ng/L (BNP) and 570 (17–5048) ng/L (NT-proBNP). Analytical variation, week-to-week CVi, and reference change values were 8.4%, 40%, and 113% (BNP), and 3.0%, 35%, and 98% (NT-proBNP). Week-to week CVis were inversely related to median BNP concentrations. Week-to week CVis for BNP were 44% (BNP ≤350 ng/L) and 30% (BNP >350 ng/L). Both BNP and NT-proBNP increased between 0800 and 1000. Median NT-proBNP/BNP ratios were inversely related to median BNP concentrations. Conclusions: The high CVis hamper interpretation of changes in BNP and NT-proBNP concentrations and may partly explain their poor diagnostic values in chronic heart failure. Easily modifiable determinants to lower CVi have not been identified. The value of BNP and NT-proBNP for chronic heart failure diagnosis, and especially for follow-up and treatment optimization of individuals, remains largely to be established.

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Forced expiratory volume in one second: Predicting return to work within 3months after chronic heart failure diagnosis

International Journal of Cardiology ◽

10.1016/j.ijcard.2015.11.079 ◽

2016 ◽

Vol 203 ◽

pp. 798-799 ◽

Cited By ~ 4

Author(s):

Piera Boschetto ◽

Alice Vaccari ◽

Rita Groccia ◽

Enrico Casimirri ◽

Mariarita Stendardo ◽

...

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Return To Work ◽

Forced Expiratory Volume ◽

Failure Diagnosis ◽

Heart Failure Diagnosis

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Chronic heart failure - diagnosis

DMW - Deutsche Medizinische Wochenschrift ◽

10.1055/s-2002-30119 ◽

2002 ◽

Vol 127 (20) ◽

pp. 1083-1088 ◽

Cited By ~ 2

Author(s):

M Kindermann ◽

I Janzen ◽

B Hennen ◽

M Böhm

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Failure Diagnosis ◽

Heart Failure Diagnosis

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A Machine Learning Approach for Chronic Heart Failure Diagnosis

Diagnostics ◽

10.3390/diagnostics11101863 ◽

2021 ◽

Vol 11 (10) ◽

pp. 1863

Author(s):

Dafni K. Plati ◽

Evanthia E. Tripoliti ◽

Aris Bechlioulis ◽

Aidonis Rammos ◽

Iliada Dimou ◽

...

Keyword(s):

Machine Learning ◽

Heart Failure ◽

Chronic Heart Failure ◽

Class Imbalance ◽

Failure Diagnosis ◽

Laboratory Findings ◽

Incremental Value ◽

Single Feature ◽

Machine Learning Approach ◽

Heart Failure Diagnosis

The aim of this study was to address chronic heart failure (HF) diagnosis with the application of machine learning (ML) approaches. In the present study, we simulated the procedure that is followed in clinical practice, as the models we built are based on various combinations of feature categories, e.g., clinical features, echocardiogram, and laboratory findings. We also investigated the incremental value of each feature type. The total number of subjects utilized was 422. An ML approach is proposed, comprising of feature selection, handling class imbalance, and classification steps. The results for HF diagnosis were quite satisfactory with a high accuracy (91.23%), sensitivity (93.83%), and specificity (89.62%) when features from all categories were utilized. The results remained quite high, even in cases where single feature types were employed.

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