Anticancer Activity of Silver-N-Heterocyclic Carbene Complexes: Caspase-Independent Induction of Apoptosis via Mitochondrial Apoptosis-Inducing Factor (AIF)

ChemMedChem ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. 805-814 ◽  
Author(s):  
Laure Eloy ◽  
Anne-Sophie Jarrousse ◽  
Marie-Laure Teyssot ◽  
Arnaud Gautier ◽  
Laurent Morel ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Mitochondrial Apoptosis ◽  
Carbene Complexes ◽  
Induction Of Apoptosis ◽  
Apoptosis Inducing Factor

scholarly journals NADH Oxidase Activity of Mitochondrial Apoptosis-inducing Factor

2001 ◽  
Vol 276 (19) ◽  
pp. 16391-16398 ◽  
Author(s):  
M. Dolores Miramar ◽  
Paola Costantini ◽  
Luigi Ravagnan ◽  
Ligia M. Saraiva ◽  
Delphine Haouzi ◽  
...  
Keyword(s):  
Oxidase Activity ◽  
Nadh Oxidase ◽  
Mitochondrial Apoptosis ◽  
Nadh Oxidase Activity ◽  
Apoptosis Inducing Factor

Synthesis, Structure, and Anticancer Activity of Symmetrical and Non-symmetrical Silver(I)-N-Heterocyclic Carbene Complexes

2020 ◽  
Vol 191 (3) ◽  
pp. 1171-1189 ◽  
Author(s):  
Muhammad Atif ◽  
Haq Nawaz Bhatti ◽  
Rosenani A. Haque ◽  
Muhammad Adnan Iqbal ◽  
Mohammad B. Ahamed Khadeer ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Carbene Complexes

scholarly journals Synthesis and anticancer activity of silver(i)–N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine

2015 ◽  
Vol 44 (16) ◽  
pp. 7563-7569 ◽  
Author(s):  
Heba A. Mohamed ◽  
Benjamin R. M. Lake ◽  
Thomas Laing ◽  
Roger M. Phillips ◽  
Charlotte E. Willans
Keyword(s):  
Anticancer Activity ◽  
Carbene Complexes

Silver–N-heterocyclic carbene complexes derived from natural xanthine products have been prepared. Chemosensitivity studies indicate a correlation between cytotoxicity, ligand sterics and hydrophilicity.

Evaluation of Anticancer Activity of Water-Soluble Curcumin through the Induction of Apoptosis by p53 and p21 Modulation

2018 ◽  
Vol 3 (11) ◽  
pp. 2976-2981 ◽  
Author(s):  
Govindharasu Banuppriya ◽  
Ganeshan Shakambari ◽  
Rajendran Sribalan ◽  
Perumal Varalakshmi ◽  
Vediappen Padmini
Keyword(s):  
Anticancer Activity ◽  
Water Soluble ◽  
Induction Of Apoptosis

scholarly journals Cysteine protease inhibition prevents mitochondrial apoptosis-inducing factor (AIF) release

2005 ◽  
Vol 12 (11) ◽  
pp. 1445-1448 ◽  
Author(s):  
V J Yuste ◽  
R S Moubarak ◽  
C Delettre ◽  
M Bras ◽  
P Sancho ◽  
...  
Keyword(s):  
Cysteine Protease ◽  
Mitochondrial Apoptosis ◽  
Protease Inhibition ◽  
Apoptosis Inducing Factor

Magnetic nanoparticles: mechanistic studies on the cancer cell interaction

2016 ◽  
Vol 5 (5) ◽  
Author(s):  
Joe Antony Jacob ◽  
Jumah Masoud Mohammad Salmani ◽  
Baoan Chen
Keyword(s):  
Cell Death ◽  
Magnetic Nanoparticles ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Cell Interaction ◽  
Mechanistic Studies ◽  
Normal Cells ◽  
Different Types ◽  
Induction Of Apoptosis ◽  
Plausible Reason

AbstractMagnetic nanoparticles are renowned for their anticancer activity. Recent studies have elucidated that magnetic nanoparticles induce cytotoxicity by induction of apoptosis in cancer cells. The magnetic nanoparticles can also be biosynthesized, and this presents an added advantage along with the concept of limited toxicity to normal cells. This review focuses on the mechanistic studies performed on the anticancer activity of different types of magnetic nanoparticles. Apoptosis was shown to be the most plausible reason behind the cell death mediated by various types of magnetic nanoparticles.

scholarly journals Chitosan exerts anticancer activity through induction of apoptosis and cell cycle arrest in oral cancer cells

2014 ◽  
Vol 56 (2) ◽  
pp. 119-126 ◽  
Author(s):  
Yuniardini S. Wimardhani ◽  
Dewi F. Suniarti ◽  
Hans J. Freisleben ◽  
Septelia I. Wanandi ◽  
Nurjati C. Siregar ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Oral Cancer ◽  
Anticancer Activity ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Cycle Arrest ◽  
Induction Of Apoptosis ◽  
Oral Cancer Cells

Oxidative modification sensitizes mitochondrial apoptosis-inducing factor to calpain-mediated processing

2010 ◽  
Vol 48 (6) ◽  
pp. 791-797 ◽  
Author(s):  
Erik Norberg ◽  
Vladimir Gogvadze ◽  
Helin Vakifahmetoglu ◽  
Sten Orrenius ◽  
Boris Zhivotovsky
Keyword(s):  
Oxidative Modification ◽  
Mitochondrial Apoptosis ◽  
Apoptosis Inducing Factor
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