New Insight into the Structure-Activity Relationships of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors UCPH-101 and UCPH-102

Structure Activity Relationships ◽

Structure Activity ◽

Acid Transporter ◽

Insight Into

Structure−Activity Relationship Study of First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101)

Journal of Medicinal Chemistry ◽

10.1021/jm1009154 ◽

2010 ◽

Vol 53 (19) ◽

pp. 7180-7191 ◽

Cited By ~ 82

Author(s):

Mette N. Erichsen ◽

Tri H. V. Huynh ◽

Bjarke Abrahamsen ◽

Jesper F. Bastlund ◽

Christoffer Bundgaard ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Structure Activity Relationship ◽

Amino Acid Transporter ◽

Selective Inhibitor ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Study ◽

Identification of a New Class of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors Followed by a Structure–Activity Relationship Study

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b01058 ◽

2016 ◽

Vol 59 (19) ◽

pp. 8757-8770 ◽

Cited By ~ 11

Author(s):

Stinne W. Hansen ◽

Mette N. Erichsen ◽

Bingru Fu ◽

Walden E. Bjørn-Yoshimoto ◽

Bjarke Abrahamsen ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Structure Activity Relationship ◽

Amino Acid Transporter ◽

Activity Relationship ◽

New Class ◽

Structure Activity ◽

Relationship Study ◽

Excitatory amino acid transporter 3 and the glutamate/cystine antiporter system Xc- cooperatively protect neuronal HT22 cells from oxidative glutamate toxicity

Aktuelle Neurologie ◽

10.1055/s-2004-833373 ◽

2004 ◽

Vol 31 (S 1) ◽

Author(s):

M Klein ◽

A Methner ◽

J Lewerenz

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Glutamate Toxicity ◽

Ht22 Cells ◽

The importance of the excitatory amino acid transporter 3 (EAAT3)

Neurochemistry International ◽

10.1016/j.neuint.2016.05.007 ◽

2016 ◽

Vol 98 ◽

pp. 4-18 ◽

Cited By ~ 30

Author(s):

Walden E. Bjørn-Yoshimoto ◽

Suzanne M. Underhill

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Excitatory Amino Acid Transporter

Encyclopedia of Biophysics ◽

10.1007/978-3-642-16712-6_100291 ◽

2013 ◽

pp. 715-715

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Association study of the excitatory amino acid transporter 2 (EAAT2) and glycine transporter 1 (GlyT1) gene polymorphism with schizophrenia in a Polish population

Neuropsychiatric Disease and Treatment ◽

10.2147/ndt.s194924 ◽

2019 ◽

Vol Volume 15 ◽

pp. 989-1000 ◽

Cited By ~ 1

Author(s):

Wojciech Merk ◽

Krzysztof Kucia ◽

Tomasz Mędrala ◽

Małgorzata Kowalczyk ◽

Aleksander Owczarek ◽

...

Keyword(s):

Amino Acid ◽

Gene Polymorphism ◽

Association Study ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Polish Population ◽

Glycine Transporter 1 ◽

Glycine Transporter ◽

Identification and Structure–Activity Relationship Study of Imidazo[1,2-a]pyridine-3-amines as First Selective Inhibitors of Excitatory Amino Acid Transporter Subtype 3 (EAAT3)

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.9b00447 ◽

2019 ◽

Vol 10 (10) ◽

pp. 4414-4429

Author(s):

Peng Wu ◽

Walden E. Bjørn-Yoshimoto ◽

Markus Staudt ◽

Anders A. Jensen ◽

Lennart Bunch

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Structure Activity Relationship ◽

Amino Acid Transporter ◽

Activity Relationship ◽

Selective Inhibitors ◽

Structure Activity ◽

Relationship Study ◽

Subtype 3

Synthesis and Biological Evaluation of Novel Neuroprotective Pyridazine Derivatives as Excitatory Amino Acid Transporter 2 (EAAT2) Activators

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00383 ◽

2017 ◽

Vol 60 (12) ◽

pp. 5216-5221 ◽

Cited By ~ 5

Author(s):

Alessia Chelini ◽

Simone Brogi ◽

Marco Paolino ◽

Angela Di Capua ◽

Andrea Cappelli ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

Acid Transporter ◽

Pyridazine Derivatives ◽

Decrease of aquaporin-4 and excitatory amino acid transporter-2 indicate astrocyte dysfunction for pathogenesis of cortical degeneration in HIV-associated neurocognitive disorders

Neuropathology ◽

10.1111/neup.12321 ◽

2016 ◽

Vol 37 (1) ◽

pp. 25-34 ◽

Cited By ~ 7

Author(s):

Hui Qin Xing ◽

Yu Zhang ◽

Kimiko Izumo ◽

Shiho Arishima ◽

Ryuji Kubota ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Neurocognitive Disorders ◽

Aquaporin 4 ◽

Hiv Associated Neurocognitive Disorders

Acid Transporter ◽

Prion protein regulates glutathione metabolism and neural glutamate and cysteine uptake via excitatory amino acid transporter 3

Journal of Neurochemistry ◽

10.1111/jnc.13071 ◽

2015 ◽

Vol 133 (4) ◽

pp. 558-571 ◽

Cited By ~ 8

Author(s):

Kathrin Guitart ◽

Gabriele Loers ◽

Melitta Schachner ◽

Ralf Kleene

Keyword(s):

Amino Acid ◽

Prion Protein ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Glutathione Metabolism ◽

Acid Transporter ◽

Cysteine Uptake