Fast NMR Methods for Measuring in the Direct and/or Competition Mode the Dissociation Constants of Chemical Fragments Interacting with a Receptor

ChemMedChem ◽  
2019 ◽  
Vol 14 (11) ◽  
pp. 1115-1127 ◽  
Author(s):  
Claudio Dalvit ◽  
Annick Parent ◽  
Francois Vallée ◽  
Magali Mathieu ◽  
Alexey Rak
Keyword(s):  
Dissociation Constants ◽  
Fast Nmr ◽  
Competition Mode ◽  
Nmr Methods

Fast NMR Methods for Identification of Resonances and Metabolic Pathways

2019 ◽  
pp. 135-147
Author(s):  
Abhinav Dubey ◽  
Shivanand M. Pudakalakatti ◽  
Hanudatta S. Atreya
Keyword(s):  
Metabolic Pathways ◽  
Fast Nmr ◽  
Nmr Methods

NMR Methods for the Determination of Protein- Ligand Dissociation Constants

2003 ◽  
Vol 3 (1) ◽  
pp. 39-53 ◽  
Author(s):  
Lee Fielding
Keyword(s):  
Dissociation Constants ◽  
Ligand Dissociation ◽  
Nmr Methods

Paramagnetic relaxation enhancement to improve sensitivity of fast NMR methods: application to intrinsically disordered proteins

2011 ◽  
Vol 51 (4) ◽  
pp. 487-495 ◽  
Author(s):  
François-Xavier Theillet ◽  
Andres Binolfi ◽  
Stamatis Liokatis ◽  
Silvia Verzini ◽  
Philipp Selenko
Keyword(s):  
Intrinsically Disordered Proteins ◽  
Paramagnetic Relaxation ◽  
Paramagnetic Relaxation Enhancement ◽  
Disordered Proteins ◽  
Fast Nmr ◽  
Intrinsically Disordered ◽  
Nmr Methods

scholarly journals Accelerating NMR-Based Structural Studies of Proteins by Combining Amino Acid Selective Unlabeling and Fast NMR Methods

2017 ◽  
Vol 4 (1) ◽  
pp. 2 ◽  
Author(s):  
Bankala Krishnarjuna ◽  
Kousik Chandra ◽  
Hanudatta Atreya
Keyword(s):  
Amino Acid ◽  
Structural Studies ◽  
Fast Nmr ◽  
Nmr Methods

Fast NMR Data Acquisition

2017 ◽  
Keyword(s):  
Data Acquisition ◽  
Fast Nmr ◽  
Nmr Data

Isolation and characterization of complex oligomeric proanthocyanidins from grape: applications of CCC and high field multidimensional NMR methods

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
KB Killday ◽  
JA Glinski ◽  
M Davey ◽  
R Kane ◽  
MS Tempesta
Keyword(s):  
High Field ◽  
Multidimensional Nmr ◽  
Oligomeric Proanthocyanidins ◽  
Isolation And Characterization ◽  
Nmr Methods

Factors Influencing the Separation of Glu-Plasminogen Affinity Forms I and II by Affinity Chromatography

1984 ◽  
Vol 52 (03) ◽  
pp. 347-349 ◽  
Author(s):  
Daan W Traas ◽  
Bep Hoegee-de Nobel ◽  
Willem Nieuwenhuizen
Keyword(s):  
Affinity Chromatography ◽  
Dissociation Constants ◽  
Ionic Composition ◽  
Chloride Ions ◽  
Factors Influencing ◽  
Two Factors ◽  
Human Plasminogen

SummaryNative human plasminogen, the proenzyme of plasmin (E. C. 3.4.21.7) occurs in blood in two well defined forms, affinity forms I and II. In this paper, the feasibility of separating these forms of human native plasminogen by affinity chromatography, is shown to be dependent on two factors: 1) the ionic composition of the buffer containing the displacing agent: buffers of varying contents of sodium, Tris, phosphate and chloride ions were compared, and 2) the type of adsorbent. Two adsorbents were compared: Sepharose-lysine and Sepharose-bisoxirane-lysine. Only in the phosphate containing buffers, irrespective of the type of adsorbent, the affinity forms can be separated. The influence of the adsorbent can be accounted for by a large difference in dissociation constants of the complex between plasminogen and the immobilized lysine.

Determination of acidic dissociation constants of L-phenylalanyl-glycine and L-alanyl-L-alanine in water using ab initio methods

2014 ◽  
Vol 2 (42) ◽  
pp. 263-263
Author(s):  
Farhoush Kiani ◽  
Mahmoud Tajbakhsh ◽  
Fereydoon Ashrafi ◽  
Nesa Shafiei ◽  
Azar Bahadori ◽  
...  
Keyword(s):  
Ab Initio ◽  
Dissociation Constants ◽  
Ab Initio Methods ◽  
Acidic Dissociation
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