scholarly journals Early changes in tumor size in patients treated for advanced stage nonsmall cell lung cancer do not correlate with survival

Cancer ◽  
2009 ◽  
Vol 115 (3) ◽  
pp. 581-586 ◽  
Author(s):  
Katherine R. Birchard ◽  
Jenny K. Hoang ◽  
James E. Herndon ◽  
Edward F. Patz
Cancer ◽  
2006 ◽  
Vol 107 (4) ◽  
pp. 781-792 ◽  
Author(s):  
Sumithra J. Mandrekar ◽  
Steven E. Schild ◽  
Shauna L. Hillman ◽  
Katie L. Allen ◽  
Randolph S. Marks ◽  
...  

2005 ◽  
Vol 79 (4) ◽  
pp. 1137-1141 ◽  
Author(s):  
Özcan Birim ◽  
A. Pieter Kappetein ◽  
Johanna J.M. Takkenberg ◽  
Rob J. van Klaveren ◽  
Ad J.J.C. Bogers

2017 ◽  
Vol 49 (3) ◽  
pp. 1601520 ◽  
Author(s):  
Jon Zugazagoitia ◽  
Sonia Molina-Pinelo ◽  
Fernando Lopez-Rios ◽  
Luis Paz-Ares

Biological therapies have improved survival outcomes of advanced-stage nonsmall cell lung cancer (NSCLC). Genotype-directed therapies have changed treatment paradigms of patients withEGFR-mutant andALK/ROS1-rearranged lung adenocarcinomas, and the list of druggable targets with demonstrated clinical actionability (BRAF, MET, RET, NTRK1andHER2) continues to expand. Furthermore, we have incrementally understood the mechanisms of cancer immune evasion and foresee ways to effectively circumvent them, particularly at the immune checkpoint level. Drugs targeting the tumour immune-evasive PD-1 pathway have demonstrated remarkable treatment benefits in this disease, with a non-negligible fraction of patients potentially receiving long-term survival benefits. Herein, we briefly discuss the role of various medical disciplines in the management of advanced-stage NSCLC and review the most relevant biological therapies for this disease, with particular emphasis in genotype-directed therapies and immune checkpoint inhibitors.


Medicine ◽  
2018 ◽  
Vol 97 (32) ◽  
pp. e11628 ◽  
Author(s):  
Mehrdad Bakhshayesh Karam ◽  
Abtin Doroudinia ◽  
Bahareh Behzadi ◽  
Payam Mehrian ◽  
Abbas Yousefi Koma

Cancer ◽  
2007 ◽  
Vol 112 (1) ◽  
pp. 136-143 ◽  
Author(s):  
Jason A. Zell ◽  
S.-H. Ignatius Ou ◽  
Argyrios Ziogas ◽  
Hoda Anton-Culver

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