Author response for "Regional differences in beta amyloid plaque deposition and variable response to midlife environmental enrichment in the cortex of APP / PS1 mice"

2020 ◽  
Author(s):  
Barbora Fulopova ◽  
Kimberley E. Stuart ◽  
William Bennett ◽  
Aidan Bindoff ◽  
Anna E. King ◽  
...  
Keyword(s):  
Regional Differences ◽  
Environmental Enrichment ◽  
Amyloid Plaque ◽  
Beta Amyloid ◽  
Author Response ◽  
Variable Response ◽  
Plaque Deposition

scholarly journals Early candidate urine biomarkers for detecting Alzheimer’s disease before beta amyloid plaque deposition in an APP (swe)/PSEN1dE9transgenic mouse model

2018 ◽  
Author(s):  
Fanshuang Zhang ◽  
Jing Wei ◽  
Xundou Li ◽  
Chao Ma ◽  
Youhe Gao
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Neurodegenerative Disorder ◽  
Amyloid Plaque ◽  
Beta Amyloid ◽  
Plaque Deposition ◽  
Urine Biomarkers ◽  
Old Mice

AbstractAlzheimer’s disease (AD) is an incurable age-associated neurodegenerative disorder that is characterized by irreversible progressive cognitive deficits and extensive brain damage. The identification of candidate biomarkers before beta amyloid plaque deposition occurs is therefore of great importance for the early intervention of AD. Urine, which is not regulated by homeostatic mechanisms, theoretically accumulates changes associated with AD earlier than cerebrospinal fluid and blood. In this study, an APP (swe)/PSEN1dE9 transgenic mouse model was used to identify candidate biomarkers for early AD. Urine samples were collected from 4-, 6-, and 8-month-old transgenic mouse models, and the urinary proteomes were profiled using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). The levels of 33 proteins differed significantly between wild-type and 4-month-old mice, which had not started to deposit beta amyloid plaque. Among these proteins, 16 have been associated with the mechanisms of AD, while 9 have been suggested as AD biomarkers. Our results indicated that urine proteins enable detecting AD before beta amyloid plaque deposition, which may present an opportunity for intervention.

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