An Ex Vivo Acid Injury and Repair (AIR) Model Using Precision‐Cut Lung Slices to Understand Lung Injury and Repair

2020 ◽  
Vol 10 (4) ◽  
Author(s):  
Sally Yunsun Kim ◽  
Róisín Mongey ◽  
Mark Griffiths ◽  
Matthew Hind ◽  
Charlotte H. Dean
Keyword(s):  
Lung Injury ◽  
Ex Vivo ◽  
Injury And Repair ◽  
Precision Cut Lung Slices

LSC - 2019 - A novel ex-vivo approach to study lung injury and repair

2019 ◽  
Author(s):  
Sally Yunsun Kim ◽  
Róisín Mongey ◽  
Peizhu Wang ◽  
Matthew Hind ◽  
Mark Griffiths ◽  
...  
Keyword(s):  
Lung Injury ◽  
Ex Vivo ◽  
Injury And Repair ◽  
Ex Vivo Approach

A novel ex-vivo approach to study lung injury and repair

2019 ◽  
Author(s):  
Sally Yunsun Kim ◽  
Róisín Mongey ◽  
Peizhu Wang ◽  
Matthew Hind ◽  
Mark Griffiths ◽  
...  
Keyword(s):  
Lung Injury ◽  
Ex Vivo ◽  
Injury And Repair ◽  
Ex Vivo Approach

Precision cut lung slices: an ex vivo model for assessing the impact of immunomodulatory therapeutics on lung immune responses

2021 ◽  
Author(s):  
Guanghui Liu ◽  
Linnea Särén ◽  
Helena Douglasson ◽  
Xiao-Hong Zhou ◽  
Per M. Åberg ◽  
...  
Keyword(s):  
Immune Responses ◽  
Ex Vivo ◽  
Ex Vivo Model ◽  
Precision Cut Lung Slices ◽  
The Impact

scholarly journals Conceptual Approaches to Lung Injury and Repair

2015 ◽  
Vol 12 (Supplement 1) ◽  
pp. S9-S15 ◽  
Author(s):  
Rachel L. Zemans ◽  
Peter M. Henson ◽  
Jan E. Henson ◽  
William J. Janssen
Keyword(s):  
Lung Injury ◽  
Injury And Repair

scholarly journals Metabolomics Investigation Reveals Metabolite Mediators Associated with Acute Lung Injury and Repair in a Murine Model of Influenza Pneumonia

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Liang Cui ◽  
Dahai Zheng ◽  
Yie Hou Lee ◽  
Tze Khee Chan ◽  
Yadunanda Kumar ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Murine Model ◽  
Influenza Pneumonia ◽  
Injury And Repair

Acute Lung Injury and Repair

2017 ◽  
Vol 125 (5) ◽  
pp. 1809 ◽  
Author(s):  
Jay Berger ◽  
Ellise Delphin
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Injury And Repair

High oxygen concentrations predispose mouse lungsto the deleterious effects of high stretch ventilation

2003 ◽  
Vol 94 (3) ◽  
pp. 975-982 ◽  
Author(s):  
Timothy C. Bailey ◽  
Erica L. Martin ◽  
Lin Zhao ◽  
Ruud A. W. Veldhuizen
Keyword(s):  
Mechanical Ventilation ◽  
Acute Lung Injury ◽  
Lung Function ◽  
Lung Injury ◽  
Inflammatory Cytokines ◽  
Pulmonary Surfactant ◽  
Ex Vivo ◽  
Lung Stretch ◽  
Isolated Lungs ◽  
Mechanical Ventilation Group

Mechanical ventilation is a necessary intervention for patients with acute lung injury. However, mechanical ventilation can propagate acute lung injury and increase systemic inflammation. The exposure to >21% oxygen is often associated with mechanical ventilation yet has not been examined within the context of lung stretch. We hypothesized that mice exposed to >90% oxygen will be more susceptible to the deleterious effects of high stretch mechanical ventilation. C57B1/6 mice were randomized into 48-h exposure of 21 or >90% oxygen; mice were then killed, and isolated lungs were randomized into a nonstretch or an ex vivo, high-stretch mechanical ventilation group. Lungs were assessed for compliance and lavaged for surfactant analysis, and cytokine measurements or lungs were homogenized for surfactant-associated protein analysis. Mice exposed to >90% oxygen + stretch had significantly lower compliance, altered pulmonary surfactant, and increased inflammatory cytokines compared with all other groups. Our conclusion is that 48 h of >90% oxygen and high-stretch mechanical ventilation deleteriously affect lung function to a greater degree than stretch alone.

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