Biomarker‐informed model‐based risk assessment of organic anion transporting polypeptide 1B mediated drug‐drug interactions

2021 ◽  
Author(s):  
Emi Kimoto ◽  
Chester Costales ◽  
Mark A. West ◽  
Yi‐an Bi ◽  
Manoli Vourvahis ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Drug Interactions ◽  
Organic Anion ◽  
Organic Anion Transporting Polypeptide ◽  
Model Based

Pitavastatin as an In Vivo Probe for Studying Hepatic Organic Anion Transporting Polypeptide-Mediated Drug–Drug Interactions in Cynomolgus Monkeys

2013 ◽  
Vol 41 (10) ◽  
pp. 1875-1882 ◽  
Author(s):  
Tsuyoshi Takahashi ◽  
Tatsuyuki Ohtsuka ◽  
Takahiro Yoshikawa ◽  
Ichiro Tatekawa ◽  
Yasuhiro Uno ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Organic Anion ◽  
Cynomolgus Monkeys ◽  
Organic Anion Transporting Polypeptide

scholarly journals P-glycoprotein- and organic anion-transporting polypeptide-mediated transport of periplocin may lead to drug–herb/drug–drug interactions

2014 ◽  
pp. 475 ◽  
Author(s):  
Xin He ◽  
Sheng Liang ◽  
Fengchun Deng ◽  
Haiyan Xing ◽  
He Wen ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Organic Anion ◽  
Organic Anion Transporting Polypeptide ◽  
P Glycoprotein

Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug Interactions

2010 ◽  
Vol 38 (9) ◽  
pp. 1612-1622 ◽  
Author(s):  
Mingxiang Liao ◽  
Arek R. Raczynski ◽  
Michael Chen ◽  
Bei-Ching Chuang ◽  
Qing Zhu ◽  
...  
Keyword(s):  
Rna Interference ◽  
Drug Interactions ◽  
In Vitro Model ◽  
Organic Anion ◽  
Human Hepatocytes ◽  
Organic Anion Transporting Polypeptide ◽  
Vitro Model

Effect of Hepatic Organic Anion‐Transporting Polypeptide 1B Inhibition and Chronic Kidney Disease on the Pharmacokinetics of a Liver‐Targeted Glucokinase Activator: A Model‐Based Evaluation

2019 ◽  
Vol 106 (4) ◽  
pp. 792-802 ◽  
Author(s):  
Arthur Bergman ◽  
Yi‐an Bi ◽  
Sumathy Mathialagan ◽  
John Litchfield ◽  
David J. Kazierad ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Organic Anion ◽  
Glucokinase Activator ◽  
Organic Anion Transporting Polypeptide ◽  
Model Based

scholarly journals Glycyrrhizin has a high likelihood to be a victim of drug-drug interactions mediated by hepatic organic anion-transporting polypeptide 1B1/1B3

2018 ◽  
Vol 175 (17) ◽  
pp. 3486-3503 ◽  
Author(s):  
Jiajia Dong ◽  
Olajide E Olaleye ◽  
Rongrong Jiang ◽  
Jing Li ◽  
Chuang Lu ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Organic Anion ◽  
High Likelihood ◽  
Organic Anion Transporting Polypeptide

scholarly journals Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions

2016 ◽  
Vol 13 (3) ◽  
pp. 839-851 ◽  
Author(s):  
Khondoker Alam ◽  
Sonia Pahwa ◽  
Xueying Wang ◽  
Pengyue Zhang ◽  
Kai Ding ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Organic Anion ◽  
Transport Function ◽  
Organic Anion Transporting Polypeptide

Contribution of organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 to hepatic uptake of nateglinide, and the prediction of drug-drug interactions via these transporters

2011 ◽  
Vol 64 (2) ◽  
pp. 199-206 ◽  
Author(s):  
Toshiyuki Takanohashi ◽  
Satoru Kubo ◽  
Harumi Arisaka ◽  
Kenji Shinkai ◽  
Kazuyuki Ubukata
Keyword(s):  
Drug Interactions ◽  
Organic Anion ◽  
Hepatic Uptake ◽  
Organic Anion Transporting Polypeptide
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