This paper reviews the supply chain management literature to summarize best-practice guidelines for mitigating supply problems. Very few studies in the extant literature focused on matching a strategy for both the supply and demand perspective. Case studies of supply chain management have traditionally focused on single companies, and especially on successful organizations rather than on the demand-supply-chain relationships (which involve at least two companies). Therefore, this study considers the experiences of the author, and researchers several well-known profitable fortune 1000 supply chain companies, to determine which supply chain mitigation strategies work best in complex situations.