Continuous‐Flow Visible Light Organophotocatalysis for Direct Arylation of 2 H ‐Indazoles: Fast Access to Drug Molecules

ChemSusChem ◽  
2019 ◽  
Vol 12 (12) ◽  
pp. 2581-2586 ◽  
Author(s):  
Shinde Vidyacharan ◽  
Bandaru T. Ramanjaneyulu ◽  
Seungwook Jang ◽  
Dong‐Pyo Kim
Keyword(s):  
Visible Light ◽  
Continuous Flow ◽  
Direct Arylation ◽  
Drug Molecules ◽  
Fast Access

Visible Light-Mediated Oxidative Debenzylation

2020 ◽  
Author(s):  
Cristian Cavedon ◽  
Eric T. Sletten ◽  
Amiera Madani ◽  
Olaf Niemeyer ◽  
Peter H. Seeberger ◽  
...  
Keyword(s):  
Reaction Time ◽  
Visible Light ◽  
Functional Groups ◽  
Continuous Flow ◽  
Protecting Groups ◽  
Benzyl Ether ◽  
Complex Molecules ◽  
Protective Groups ◽  
Benzyl Ethers ◽  
Harsh Conditions

Protecting groups are key in the synthesis of complex molecules such as carbohydrates to distinguish functional groups of similar reactivity. The harsh conditions required to cleave stable benzyl ether protective groups are not compatible with many other protective and functional groups. The mild, visible light-mediated debenzylation disclosed here renders benzyl ethers orthogonal protective groups. Key to success is the use of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as stoichiometric or catalytic photooxidant such that benzyl ethers can be cleaved in the presence of azides, alkenes, and alkynes. The reaction time for this transformation can be reduced from hours to minutes in continuous flow. <br>

Visible light-induced iniferter polymerization of methacrylates enhanced by continuous flow

2017 ◽  
Vol 8 (42) ◽  
pp. 6496-6505 ◽  
Author(s):  
Maarten Rubens ◽  
Phanumat Latsrisaeng ◽  
Tanja Junkers
Keyword(s):  
Block Copolymers ◽  
Visible Light ◽  
Continuous Flow ◽  
Flow Reactors ◽  
Continuous Flow Reactors

Visible-light induced photoiniferter polymerization in continuous flow reactors is very efficient in yielding low dispersity methacrylate block copolymers.

scholarly journals Photonic contacting of gas–liquid phases in a falling film microreactor for continuous-flow photochemical catalysis with visible light

2016 ◽  
Vol 1 (6) ◽  
pp. 636-648 ◽  
Author(s):  
Thomas H. Rehm ◽  
Sylvain Gros ◽  
Patrick Löb ◽  
Albert Renken
Keyword(s):  
Visible Light ◽  
Process Evaluation ◽  
Continuous Flow ◽  
Falling Film ◽  
Dye Sensitized ◽  
Photochemical Conversion ◽  
Liquid Phases ◽  
Film Reactor ◽  
Photochemical Catalysis

A microstructured falling film reactor was applied to the dye-sensitized photochemical conversion of 1,5-dihydroxynaphthalene to juglone for reactor and process evaluation.

scholarly journals Metal-Free Visible-Light-Mediated Hydrotrifluoromethylation of Unactivated Alkenes and Alkynes in Continuous Flow

2019 ◽  
Vol 2020 (10) ◽  
pp. 1429-1432 ◽  
Author(s):  
Anne-Laure Barthelemy ◽  
Guillaume Dagousset ◽  
Emmanuel Magnier
Keyword(s):  
Visible Light ◽  
Continuous Flow ◽  
Metal Free

Continuous-flow photo-induced decarboxylative annulative access to fused imidazole derivatives via a microreactor containing immobilized ruthenium

2020 ◽  
Vol 22 (5) ◽  
pp. 1565-1571 ◽  
Author(s):  
Praveen Reddy Adiyala ◽  
Seungwook Jang ◽  
Niraj K. Vishwakarma ◽  
Yoon-Ho Hwang ◽  
Dong-Pyo Kim
Keyword(s):  
Visible Light ◽  
Continuous Flow ◽  
Imidazole Derivatives ◽  
Polydimethylsiloxane Microreactor

Continuous-flow visible-light-induced decarboxylative annulation using a polydimethylsiloxane microreactor containing immobilized Ru3+ has been established for the construction of fused imidazole derivatives.

Visible Light-Promoted C–C Bond Formation from Hydroxyaryls in Water

2019 ◽  
Vol 72 (12) ◽  
pp. 978 ◽  
Author(s):  
Dafne Saporito ◽  
Sergio A. Rodriguez ◽  
Maria T. Baumgartner
Keyword(s):  
Visible Light ◽  
Bond Formation ◽  
High Yield ◽  
Reaction Yield ◽  
Halogen Lamp ◽  
One Pot ◽  
Direct Arylation ◽  
Photoinduced Reactions ◽  
Optical Applications ◽  
Very High

An eco-friendly and direct arylation of hydroxyaryls in water using photoinduced reactions with different substrates (1-bromo-2-naphthol, 1-iodo-2-naphthol, N-(2-iodophenyl)acetamide, 5-bromouracil, 2-iodo-N-methylbenzamide, and 2-iodobenzamide) was studied. For example, π-expanded coumarins, compounds with potential optical applications, were synthesized in very high yield, without the use of toxic reagents, in a one-pot reaction. In addition, we demonstrate that the irradiation source (halogen lamp) can be efficiently replaced by an LED without altering the reaction yield.

Visible Light-Mediated Polymerization-Induced Self-Assembly Using Continuous Flow Reactors

2018 ◽  
Vol 51 (14) ◽  
pp. 5165-5172 ◽  
Author(s):  
Neomy Zaquen ◽  
Jonathan Yeow ◽  
Tanja Junkers ◽  
Cyrille Boyer ◽  
Per B. Zetterlund
Keyword(s):  
Visible Light ◽  
Self Assembly ◽  
Continuous Flow ◽  
Flow Reactors ◽  
Continuous Flow Reactors

Visible light induced regioselective C5 halogenation of 8-aminoquinolines with 1,3-dihalo-5,5-dimethylhydantoin in continuous flow

Tetrahedron ◽  
2019 ◽  
Vol 75 (26) ◽  
pp. 3636-3642 ◽  
Author(s):  
Quan Shu ◽  
Yaming Li ◽  
Tong Liu ◽  
Siyu Zhang ◽  
Linlin Jiang ◽  
...  
Keyword(s):  
Visible Light ◽  
Continuous Flow

Continuous Flow α-Trifluoromethylation of Ketones by Metal-Free Visible Light Photoredox Catalysis

2014 ◽  
Vol 16 (3) ◽  
pp. 896-899 ◽  
Author(s):  
David Cantillo ◽  
Oscar de Frutos ◽  
Juan A. Rincón ◽  
Carlos Mateos ◽  
C. Oliver Kappe
Keyword(s):  
Visible Light ◽  
Continuous Flow ◽  
Photoredox Catalysis ◽  
Metal Free
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