scholarly journals Single‐cell transcriptomics analysis of mild cognitive impairment in World Trade Center disaster responders

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Pei‐Fen Kuan ◽  
Sean Clouston ◽  
Xiaohua Yang ◽  
Chang Che ◽  
Samuel Gandy ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Single Cell ◽  
World Trade ◽  
World Trade Center ◽  
World Trade Center Disaster ◽  
Trade Center

scholarly journals Incidence of mild cognitive impairment in World Trade Center responders: Long‐term consequences of re‐experiencing the events on 9/11/2001

2019 ◽  
Vol 11 (1) ◽  
pp. 628-636 ◽  
Author(s):  
Sean A.P. Clouston ◽  
Erica D. Diminich ◽  
Roman Kotov ◽  
Robert H. Pietrzak ◽  
Marcus Richards ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
World Trade ◽  
World Trade Center ◽  
Trade Center ◽  
Long Term Consequences

scholarly journals Longitudinal characterization of mild cognitive impairment and dementia in World Trade Center responders at midlife

2021 ◽  
Vol 17 (S6) ◽  
Author(s):  
Sean A.P. Clouston ◽  
Frank P Mann ◽  
Erica D Diminich ◽  
Minos Kritikos ◽  
Alison Pellecchia ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
World Trade ◽  
World Trade Center ◽  
Trade Center

P4-161: INCIDENCE OF MILD COGNITIVE IMPAIRMENT IN A SAMPLE OF WORLD TRADE CENTER RESPONDERS: THE LONG-TERM IMPLICATIONS OF RE-EXPERIENCING THE EVENT

2006 ◽  
Vol 14 (7S_Part_28) ◽  
pp. P1501-P1501
Author(s):  
Sean Clouston ◽  
Roman Kotov ◽  
Yael Deri ◽  
Robert H. Pietrzak ◽  
Marcus Richards ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
World Trade ◽  
World Trade Center ◽  
Trade Center

scholarly journals White Matter Connectivity in Incident Mild Cognitive Impairment: A Diffusion Spectrum Imaging Study of World Trade Center Responders at Midlife

2021 ◽  
pp. 1-11
Author(s):  
Chuan Huang ◽  
Minos Kritikos ◽  
Sean A.P. Clouston ◽  
Yael Deri ◽  
Mario Serrano-Sosa ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
World Trade ◽  
World Trade Center ◽  
Anterior Cingulate ◽  
Diffusion Spectrum Imaging ◽  
Trade Center ◽  
Spectrum Imaging ◽  
White Matter Connectivity

Background: Individuals who participated in response efforts at the World Trade Center (WTC) following 9/11/2001 are experiencing elevated incidence of mild cognitive impairment (MCI) at midlife. Objective: We hypothesized that white matter connectivity measured using diffusion spectrum imaging (DSI) would be restructured in WTC responders with MCI versus cognitively unimpaired responders. Methods: Twenty responders (mean age 56; 10 MCI/10 unimpaired) recruited from an epidemiological study were characterized using NIA-AA criteria alongside controls matched on demographics (age/sex/occupation/race/education). Axial DSI was acquired on a 3T Siemen’s Biograph mMR scanner (12-channel head coil) using a multi-band diffusion sequence. Connectometry examined whole-brain tract-level differences in white matter integrity. Fractional anisotropy (FA), mean diffusivity (MD), and quantified anisotropy were extracted for region of interest (ROI) analyses using the Desikan-Killiany atlas. Results: Connectometry identified both increased and decreased connectivity within regions of the brains of responders with MCI identified in the corticothalamic pathway and cortico-striatal pathway that survived adjustment for multiple comparisons. MCI was also associated with higher FA values in five ROIs including in the rostral anterior cingulate; lower MD values in four ROIs including the left rostral anterior cingulate; and higher MD values in the right inferior circular insula. Analyses by cognitive domain revealed nominal associations in domains of response speed, verbal learning, verbal retention, and visuospatial learning. Conclusions: WTC responders with MCI at midlife showed early signs of neurodegeneration characterized by both increased and decreased white matter diffusivity in regions commonly affected by early-onset Alzheimer’s disease.

scholarly journals Neuroinflammation and Mild Cognitive Impairment in World Trade Center responders at midlife: A pilot study using [18F]-FEPPA PET imaging

2021 ◽  
pp. 100287
Author(s):  
Yael Deri ◽  
Sean A.P. Clouston ◽  
Christine DeLorenzo ◽  
John D. Gardus ◽  
Elizabeth A. Bartlett ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Pilot Study ◽  
Pet Imaging ◽  
World Trade ◽  
World Trade Center ◽  
Trade Center

scholarly journals Proteomic analysis of cognitive impairment in responders traumatized by the World Trade Center disaster

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Benjamin Luft ◽  
Sean Clouston ◽  
Roman Kotov ◽  
Evelyn Bromet ◽  
Pei‐Fen Kuan
Keyword(s):  
Cognitive Impairment ◽  
Proteomic Analysis ◽  
World Trade ◽  
World Trade Center ◽  
World Trade Center Disaster ◽  
The World ◽  
Trade Center

scholarly journals Posttraumatic stress disorder and new-onset diabetes among adult survivors of the World Trade Center disaster

2014 ◽  
Vol 66 ◽  
pp. 34-38 ◽  
Author(s):  
Sara A. Miller-Archie ◽  
Hannah T. Jordan ◽  
Ryan R. Ruff ◽  
Shadi Chamany ◽  
James E. Cone ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
World Trade ◽  
Stress Disorder ◽  
World Trade Center ◽  
Adult Survivors ◽  
World Trade Center Disaster ◽  
The World ◽  
Trade Center ◽  
New Onset
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