Point of Care Testing in Cardiac Surgery: Diagnostic Modalities to Assess Coagulation and Platelet Function

2013 ◽  
Vol 74 (7) ◽  
pp. 418-427 ◽  
Author(s):  
Marshall Stafford ◽  
Nathaen Weitzel
Keyword(s):  
Cardiac Surgery ◽  
Platelet Function ◽  
Point Of Care ◽  
Point Of Care Testing ◽  
Diagnostic Modalities

Minimal invasive extracorporeal circulation preserves platelet function after cardiac surgery: a prospective observational study

Perfusion ◽  
2019 ◽  
Vol 35 (2) ◽  
pp. 138-144
Author(s):  
Helena Argiriadou ◽  
Polychronis Antonitsis ◽  
Anna Gkiouliava ◽  
Evangelia Papapostolou ◽  
Apostolos Deliopoulos ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Correlation Coefficient ◽  
Platelet Function ◽  
Extracorporeal Circulation ◽  
Point Of Care ◽  
Postoperative Bleeding ◽  
Minimal Invasive ◽  
Elective Cardiac Surgery ◽  
Impedance Aggregometry

Introduction: Cardiac surgery on conventional cardiopulmonary bypass induces a combination of thrombocytopenia and platelet dysfunction which is strongly related to postoperative bleeding. Minimal invasive extracorporeal circulation has been shown to preserve coagulation integrity, though effect on platelet function remains unclear. We aimed to prospectively investigate perioperative platelet function in a series of patients undergoing cardiac surgery on minimal invasive extracorporeal circulation using point-of-care testing. Methods: A total of 57 patients undergoing elective cardiac surgery on minimal invasive extracorporeal circulation were prospectively recruited. Anticoagulation strategy was based on individualized heparin management and heparin level–guided protamine titration performed in all patients with a specialized point-of-care device (Hemostasis Management System – HMS Plus; Medtronic, Minneapolis, MN, USA). Platelet function was evaluated with impedance aggregometry using the ROTEM platelet (TEM International GmbH, Munich, Germany). ADPtest and TRAPtest values were assessed before surgery and after cardiopulmonary bypass. Results: ADPtest value was preserved during surgery on minimal invasive extracorporeal circulation (58.2 ± 20 U vs. 53.6 ± 21 U; p = 0.1), while TRAPtest was found significantly increased (90 ± 27 U vs. 103 ± 38 U; p = 0.03). Postoperative ADPtest and TRAPtest values were inversely related to postoperative bleeding (correlation coefficient: −0.29; p = 0.03 for ADPtest and correlation coefficient: −0.28; p = 0.04 for TRAPtest). The preoperative use of P2Y12 inhibitors was identified as the only independent predictor of a low postoperative ADPtest value (OR = 15.3; p = 0.02). Conclusion: Cardiac surgery on minimal invasive extracorporeal circulation is a platelet preservation strategy, which contributes to the beneficial effect of minimal invasive extracorporeal circulation in coagulation integrity.

scholarly journals Point-of-Care Platelet Function Testing in Cardiac Surgery: A Bundle of Measures Create Adequate Hemostatic Algorithm

2015 ◽  
Vol 29 (5) ◽  
pp. e53-e54 ◽  
Author(s):  
Mate Petricevic ◽  
Martina Zrno Mihaljevic ◽  
Marko Boban ◽  
Alexandra White ◽  
Bojan Biocina
Keyword(s):  
Cardiac Surgery ◽  
Platelet Function ◽  
Point Of Care ◽  
Platelet Function Testing ◽  
Function Testing

scholarly journals Implementing a point of care testing (POCT) service improves management of haemostatic dysfunction in cardiac surgery patients

2014 ◽  
Vol 27 (1) ◽  
pp. 49
Author(s):  
B. Pearse ◽  
D. Wall ◽  
I. Smith ◽  
D. Faulke ◽  
I. Rapchuck ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Point Of Care ◽  
Point Of Care Testing

Perioperative point of care platelet function testing and postoperative blood loss in high-risk cardiac surgery patients

Platelets ◽  
2018 ◽  
Vol 30 (8) ◽  
pp. 982-988 ◽  
Author(s):  
Eline A. Vlot ◽  
Laura M. Willemsen ◽  
Eric P.A. Van Dongen ◽  
Paul W. Janssen ◽  
Christian M. Hackeng ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
High Risk ◽  
Blood Loss ◽  
Platelet Function ◽  
Point Of Care ◽  
Postoperative Blood Loss ◽  
Platelet Function Testing ◽  
Function Testing

Preoperative Point-of-Care Platelet Function Testing in Cardiac Surgery

2015 ◽  
Vol 29 (2) ◽  
pp. 333-341 ◽  
Author(s):  
Seema Agarwal ◽  
Robert Ian Johnson ◽  
Matthew Shaw
Keyword(s):  
Cardiac Surgery ◽  
Platelet Function ◽  
Point Of Care ◽  
Platelet Function Testing ◽  
Function Testing

scholarly journals Platelet function point-of-care tests in post-bypass cardiac surgery: are they relevant?

2002 ◽  
Vol 89 (5) ◽  
pp. 715-721 ◽  
Author(s):  
F. Forestier ◽  
A. Coiffic ◽  
C. Mouton ◽  
D. Ekouevi ◽  
G. Chene ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Platelet Function ◽  
Point Of Care ◽  
Function Point ◽  
Point Of Care Tests
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