Vasoactive properties of phenylpropanolamine (d, I-norephedrine) and its enantiomers in isolated rat caudal artery

SummaryRidogrel (6.3 × 10−6 to 10−4 M) inhibited contractions of isolated rat caudal arteries and rabbit femoral arteries caused by U-46619. The slope of an Arunlakshana-Schild plot (pA2-value: 3.4 × 10−6 M) on the caudal artery was slightly higher than one (1.14). This effect was maximal within}D min of incubation of the blood vessel with the compound and easily reversible. Ridogrel antagonised contractions of isolated rabbit femoral arteries caused by prostaglandin Fzo2α in the same concentration range. Ridogrel also inhibited contractions induced by aggregating rat platelets on isolated rat caudal arteries (itt the presence of ketanserin 4 × 10−7 M) and on isolated rabbit pulmonary and femoral arteries (in the absence of ketanserin). Ridogrel had no effect on Ca2+-induced contractions in depolarised isolated rabbit femoral arteries, and at 10−4 M antagonised serotonin-induced contractions in this blood vessel. Its effect on serotonin-induced contractions was statistically significant but very small on isolated rat caudal arteries. These observations indicate that ridogrel is an antagonist of prostaglandin endoperoxide/thromboxane A2 and prostaglandin F2α raCeptors on vascular smooth muscle.

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Effects ofdl-norephedrine and its enantiomers on norepinephrine uptake and release in isolated rat caudal artery

Journal of the Autonomic Nervous System ◽

10.1016/s0165-1838(96)00084-7 ◽

1996 ◽

Vol 61 (2) ◽

pp. 186-190 ◽

Cited By ~ 5

Author(s):

Joseph G. Hricik ◽

David A. Johnson

Keyword(s):

Norepinephrine Uptake ◽

Caudal Artery ◽

Uptake And Release ◽

Isolated Rat

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Humoral factor(s) circulating in the blood of spontaneously hypertensive rats increases vascular tone and reduces constrictive responses of isolated rat caudal artery to stimulation of sympathetic fibers of the vascular wall

Bulletin of Experimental Biology and Medicine ◽

10.1007/bf02446723 ◽

1996 ◽

Vol 121 (4) ◽

pp. 345-347

Author(s):

N. A. Medvedeva ◽

M. A. Zharkova ◽

A. A. Chuiko ◽

O. S. Medvedev

Keyword(s):

Spontaneously Hypertensive Rats ◽

Vascular Tone ◽

Vascular Wall ◽

Humoral Factor ◽

Hypertensive Rats ◽

Spontaneously Hypertensive ◽

Caudal Artery ◽

Isolated Rat ◽

Stimulation Of

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Source of ATP, ADP, AMP and Adenosine Released from Isolated Rat Caudal Artery Exposed to Noradrenaline.

Journal of Smooth Muscle Research ◽

10.1540/jsmr.33.127 ◽

1997 ◽

Vol 33 (3) ◽

pp. 127-133 ◽

Cited By ~ 6

Author(s):

Michio HASHIMOTO ◽

Kazumasa SHINOZUKA ◽

Yasuakira TANAKA ◽

Masaaki HONDA ◽

Yukisato ISHIDA ◽

...

Keyword(s):

Caudal Artery ◽

Isolated Rat

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Actions of neurohypophysial hormone analogues on perfused isolated rat caudal artery

European Journal of Pharmacology ◽

10.1016/0014-2999(70)90184-6 ◽

1970 ◽

Vol 13 (1) ◽

pp. 65-75 ◽

Cited By ~ 9

Author(s):

Ivan Krejčí ◽

Běla Kupková ◽

Ivan Vávra ◽

Josef Rudinger

Keyword(s):

Caudal Artery ◽

Isolated Rat

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Effect of cod-liver oil with a high content of polyunsaturated fatty acids (Eikonol) on myogenic tone and vasoconstrictory and vasodilatory responses of isolated rat caudal artery

Bulletin of Experimental Biology and Medicine ◽

10.1007/bf00836395 ◽

1993 ◽

Vol 115 (3) ◽

pp. 234-236 ◽

Cited By ~ 1

Author(s):

F. Z. Meerson ◽

S. Yu. Mashina

Keyword(s):

Fatty Acids ◽

Polyunsaturated Fatty Acids ◽

Myogenic Tone ◽

Cod Liver Oil ◽

Caudal Artery ◽

Isolated Rat

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Ultrastructural changes in isolated rat liver perfused with cyclic heptapeptide toxins from norwegian freshwater cyanobacteria (blue-green algae)

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100128572 ◽

1987 ◽

Vol 45 ◽

pp. 858-859

Author(s):

A.S. Dabholkar ◽

W.W. Carmichael ◽

K. Berg ◽

J. Wyman

Keyword(s):

Ultrastructural Changes ◽

Sprague Dawley ◽

Isolated Rat Liver ◽

Blue Green Algae ◽

Sprague Dawley Rats ◽

Cyclic Heptapeptide ◽

Intracellular Changes ◽

Oscillatoria Agardhii ◽

Rat Livers ◽

Isolated Rat

Intracellular changes in the hepatocytes of isolated rat livers perfused with cyclic heptapeptide toxins are described. The toxins used are 1) -Ala-Leu- β-methyl isoAsp-Arg-ADDA-isoGlu-mdha (M.W. 944) from Microcystis aeruginosa- Lake Akersvatn, Norway; 2) -Ala-Arg-isoAsp-Arg-ADDA-isoGlu-mdha (M.W. 1023) from Oscillatoria agardhii var. - Lake Kolbatnvatn, Norway; 3) -Ala-Arg-isoAsp-Arg-ADDA-isoGlu-dha (M.W. 1009) from Oscillatoria agardhii var. isothrix - Lake Froylandsvatn, Norway. Approximate LD intraperitoneal mouse for the toxins is 50, 500 and 1000 μg/kg respectively.Livers were removed from male Sprague Dawley rats and perfused for 15 min with a blood-free perfusate (50 ml) followed by 60 min with perfusate containing i) 25, 50, or 200 μg of M. aeruginosa toxin ii) 50, 250, 500 or 1000 μg of O. agardhii var. toxin and iii) 1000, 2000, 2500 or 5000 μg of O. agardhii var. isothrix toxin. Control livers were perfused for 75 min with the blood-free perfusate.

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