Effects ofdl-norephedrine and its enantiomers on norepinephrine uptake and release in isolated rat caudal artery

1996 ◽  
Vol 61 (2) ◽  
pp. 186-190 ◽  
Author(s):  
Joseph G. Hricik ◽  
David A. Johnson
Keyword(s):  
Norepinephrine Uptake ◽  
Caudal Artery ◽  
Uptake And Release ◽  
Isolated Rat

Effect of Ridogrel on Vascular Contractions Gaused by Vasoactive Substances Released during Platelet Activation

1990 ◽  
Vol 64 (01) ◽  
pp. 091-096 ◽  
Author(s):  
W J Janssens ◽  
F J S Cools ◽  
L A M Hoskens ◽  
J M Van Nueten
Keyword(s):  
Smooth Muscle ◽  
Blood Vessel ◽  
Platelet Activation ◽  
Prostaglandin F2α ◽  
Thromboxane A2 ◽  
Femoral Arteries ◽  
Vasoactive Substances ◽  
Caudal Artery ◽  
Isolated Rat ◽  
Rat Platelets

SummaryRidogrel (6.3 × 10−6 to 10−4 M) inhibited contractions of isolated rat caudal arteries and rabbit femoral arteries caused by U-46619. The slope of an Arunlakshana-Schild plot (pA2-value: 3.4 × 10−6 M) on the caudal artery was slightly higher than one (1.14). This effect was maximal within}D min of incubation of the blood vessel with the compound and easily reversible. Ridogrel antagonised contractions of isolated rabbit femoral arteries caused by prostaglandin Fzo2α in the same concentration range. Ridogrel also inhibited contractions induced by aggregating rat platelets on isolated rat caudal arteries (itt the presence of ketanserin 4 × 10−7 M) and on isolated rabbit pulmonary and femoral arteries (in the absence of ketanserin). Ridogrel had no effect on Ca2+-induced contractions in depolarised isolated rabbit femoral arteries, and at 10−4 M antagonised serotonin-induced contractions in this blood vessel. Its effect on serotonin-induced contractions was statistically significant but very small on isolated rat caudal arteries. These observations indicate that ridogrel is an antagonist of prostaglandin endoperoxide/thromboxane A2 and prostaglandin F2α raCeptors on vascular smooth muscle.

Uptake and release of adenosine in isolated rat fat cells

1979 ◽  
Vol 105 (3) ◽  
pp. 257-267 ◽  
Author(s):  
BERTIL B. FREDHOLM ◽  
PAUL HJEMDAHL
Keyword(s):  
Fat Cells ◽  
Rat Fat Cells ◽  
Uptake And Release ◽  
Isolated Rat

Effect of calcium channel antagonists on calcium uptake and release by isolated rat cardiac mitochondria

1988 ◽  
Vol 152 (3) ◽  
pp. 247-253 ◽  
Author(s):  
William C. Buss ◽  
Daniel D. Savage ◽  
Julie Stepanek ◽  
Sally A. Little ◽  
Linda J. McGuffee
Keyword(s):  
Calcium Channel ◽  
Calcium Uptake ◽  
Cardiac Mitochondria ◽  
Calcium Channel Antagonists ◽  
Uptake And Release ◽  
Isolated Rat

Monophasic and biphasic effects of angiotensin II and III on norepinephrine uptake and release in rat adrenal medulla

1992 ◽  
Vol 70 (6) ◽  
pp. 821-825 ◽  
Author(s):  
M. S. Vatta ◽  
L. G. Bianciotti ◽  
A. S. Locatelli ◽  
M. L. Papouchado ◽  
B. E. Fernández
Keyword(s):  
Angiotensin Ii ◽  
Adrenal Medulla ◽  
Sodium Reabsorption ◽  
Catecholamine Metabolism ◽  
Renal Tubules ◽  
Norepinephrine Release ◽  
Norepinephrine Uptake ◽  
Angiotensin Iii ◽  
Biphasic Effect ◽  
Uptake And Release

Angiotensin II and III have hypertensive effects. They induce vascular smooth muscle constriction, increase sodium reabsorption by renal tubules, stimulate the anteroventral third ventricle area, increase vasopressin and aldosterone secretions, and modify catecholamine metabolism. In this work, angiotensin II and III effects on norepinephrine uptake and release in rat adrenal medulla were investigated. Both angiotensins decreased total and neuronal norepinephrine uptake. Angiotensin II showed a biphasic effect only on evoked neuronal norepinephrine release (an earlier decrease followed by a later increase), while increasing the spontaneous norepinephrine release only after 12 min. On the other hand, angiotensin III showed a biphasic effect on evoked and spontaneous neuronal norepinephrine release. Both angiotensins altered norepinephrine distribution into intracellular stores, concentrating the amine into the granular pool and decreasing the cytosolic store. The results suggest a physiological biphasic effect of angiotensin II as well as angiotensin III that may be involved in the modulation of sympathetic activity in the rat adrenal medulla.Key words: angiotensin II, angiotensin III, norepinephrine uptake, norepinephrine release, adrenal medulla.

scholarly journals Source of ATP, ADP, AMP and Adenosine Released from Isolated Rat Caudal Artery Exposed to Noradrenaline.

1997 ◽  
Vol 33 (3) ◽  
pp. 127-133 ◽  
Author(s):  
Michio HASHIMOTO ◽  
Kazumasa SHINOZUKA ◽  
Yasuakira TANAKA ◽  
Masaaki HONDA ◽  
Yukisato ISHIDA ◽  
...  
Keyword(s):  
Caudal Artery ◽  
Isolated Rat

B and C types natriuretic peptides modulate norepinephrine uptake and release in the rat hypothalamus

1996 ◽  
Vol 65 (3) ◽  
pp. 175-184 ◽  
Author(s):  
M.S. Vatta ◽  
M. Presas ◽  
L.G. Bianciotti ◽  
V. Zarrabeitia ◽  
B.E. Fernández
Keyword(s):  
Natriuretic Peptides ◽  
Rat Hypothalamus ◽  
Norepinephrine Uptake ◽  
Uptake And Release
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