scholarly journals Adaptations to exercise training within skeletal muscle in adults with type 2 diabetes or impaired glucose tolerance: a systematic review

2009 ◽  
Vol 25 (1) ◽  
pp. 13-40 ◽  
Author(s):  
Yi Wang ◽  
David Simar ◽  
Maria A. Fiatarone Singh
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Exercise Training ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance

scholarly journals Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis

BMJ ◽  
2007 ◽  
Vol 334 (7588) ◽  
pp. 299 ◽  
Author(s):  
Clare L Gillies ◽  
Keith R Abrams ◽  
Paul C Lambert ◽  
Nicola J Cooper ◽  
Alex J Sutton ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Meta Analysis ◽  
Lifestyle Interventions

scholarly journals Decreased Thioredoxin-1 and Increased HSP90 Expression in Skeletal Muscle in Subjects with Type 2 Diabetes or Impaired Glucose Tolerance

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
M. Venojärvi ◽  
A. Korkmaz ◽  
S. Aunola ◽  
K. Hällsten ◽  
K. Virtanen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Insulin Signalling ◽  
Vastus Lateralis ◽  
Diabetes Research ◽  
Insulin Signalling Pathway ◽  
Thioredoxin 1

In diabetes, the endogenous defence systems are overwhelmed, causing various types of stress in tissues. In this study, newly diagnosed or diet-treated type 2 diabetics (T2D) (n=10) were compared with subjects with impaired glucose tolerance (IGT) (n=8). In both groups, at resting conditions, blood samples were drawn for assessing metabolic indices and skeletal muscle samples (m. vastus lateralis) were taken for the measurements of cellular defence markers: thioredoxin-1 (TRX-1) and stress proteins HSP72, HSP90. The protein level of TRX-1 was 36.1% lower (P=0.031) and HSP90 was 380% higher (P<0.001) in the T2D than in the IGT subjects, with no significant changes in HSP72. However, after the adjustment of both analyses with HOMA-IR only HSP90 difference remained significant. In conclusion, level of TRX-1 in skeletal muscle tissue was lower while that of HSP90 was higher in T2D than in IGT subjects. This may impair antioxidant defence and lead to disruptions of protein homoeostasis and redox regulation of cellular defences. Because HSP90 may be involved in sustaining functional insulin signalling pathway in type 2 diabetic muscles and higher HSP90 levels can be a consequence of type 2 diabetes, our results are potentially important for the diabetes research.

scholarly journals Ethnicity, obesity and the prevalence of impaired glucose tolerance and type 2 diabetes in PCOS: a systematic review and meta-regression

2018 ◽  
Vol 24 (4) ◽  
pp. 455-467 ◽  
Author(s):  
N S Kakoly ◽  
M B Khomami ◽  
A E Joham ◽  
S D Cooray ◽  
M L Misso ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Meta Regression
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