scholarly journals The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition)

2021 ◽  
Author(s):  
Aowen Zhuang ◽  
Felicia Y. T. Yap ◽  
Danielle J. Borg ◽  
Domenica McCarthy ◽  
Amelia Fotheringham ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Structural Composition ◽  
Foot Process Effacement ◽  
Foot Process

scholarly journals Super‐resolved local recruitment of CLDN5 to filtration slits implicates a direct relationship with podocyte foot process effacement

2021 ◽  
Author(s):  
Florian Tesch ◽  
Florian Siegerist ◽  
Eleonora Hay ◽  
Nadine Artelt ◽  
Christoph Daniel ◽  
...  
Keyword(s):  
Direct Relationship ◽  
Foot Process Effacement ◽  
Foot Process ◽  
Local Recruitment

scholarly journals Podocyte Foot Process Effacement in Postreperfusion Allograft Biopsies

2014 ◽  
Vol 97 (7) ◽  
pp. e38-e39
Author(s):  
George W. Burke ◽  
Jei-Wen Chang ◽  
Victoriano Pardo ◽  
Junichiro Sageshima ◽  
Linda Chen ◽  
...  
Keyword(s):  
Foot Process Effacement ◽  
Foot Process

scholarly journals Acute interstitial nephritis with podocyte foot-process effacement complicating Plasmodium falciparum infection

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Patrick J. Gleeson ◽  
John A. O’Regan ◽  
Teresa McHale ◽  
Helen Tuite ◽  
Louise Giblin ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Interstitial Nephritis ◽  
Acute Interstitial Nephritis ◽  
Falciparum Infection ◽  
Plasmodium Falciparum Infection ◽  
Foot Process Effacement ◽  
Foot Process

Epithelial Foot-process Effacement in Patients with Proteinuria

1979 ◽  
Vol 72 (4) ◽  
pp. 529-532 ◽  
Author(s):  
William M. Murphy ◽  
Frank L. Moretta ◽  
Alina F. Jukkola
Keyword(s):  
Foot Process Effacement ◽  
Foot Process

Novel role of Vav1-Rac1 pathway in actin cytoskeleton regulation in interleukin-13-induced minimal change-like nephropathy

2016 ◽  
Vol 130 (24) ◽  
pp. 2317-2327 ◽  
Author(s):  
Chang-Yien Chan ◽  
Kar-Hui Ng ◽  
Jinmiao Chen ◽  
Jinhua Lu ◽  
Caroline Guat-Lay Lee ◽  
...  
Keyword(s):  
Actin Cytoskeleton ◽  
Rat Model ◽  
Minimal Change ◽  
Down Regulation ◽  
Interleukin 13 ◽  
Foot Process Effacement ◽  
Foot Process ◽  
Cytoskeleton Rearrangement

Podocyte foot process effacement and proteinuria seen in our interleukin-13 (IL-13) overexpression rat model of minimal change-like nephropathy was associated with marked down-regulation of podocyte-related genes and activation of Vav1-Rac1-induced actin cytoskeleton rearrangement in the podocytes.

scholarly journals Podocyte Foot Process Effacement in Postreperfusion Allograft Biopsies Correlates With Early Recurrence of Proteinuria in Focal Segmental Glomerulosclerosis

2012 ◽  
Vol 93 (12) ◽  
pp. 1238-1244 ◽  
Author(s):  
Jei-Wen Chang ◽  
Victoriano Pardo ◽  
Junichiro Sageshima ◽  
Linda Chen ◽  
Hsin-Lin Tsai ◽  
...  
Keyword(s):  
Focal Segmental Glomerulosclerosis ◽  
Early Recurrence ◽  
Segmental Glomerulosclerosis ◽  
Foot Process Effacement ◽  
Foot Process

Morphometric Analysis of Podocyte Foot Process Effacement in IgA Nephropathy and Its Association with Proteinuria

2010 ◽  
Vol 34 (4) ◽  
pp. 195-198 ◽  
Author(s):  
Song Yi Choi ◽  
Kwang Sun Suh ◽  
Dae Eun Choi ◽  
Beom Jin Lim
Keyword(s):  
Iga Nephropathy ◽  
Morphometric Analysis ◽  
Foot Process Effacement ◽  
Foot Process

scholarly journals Cosmc-dependent mucin-type O-linked glycosylation is essential for podocyte function

2020 ◽  
Vol 318 (2) ◽  
pp. F518-F530
Author(s):  
Brian R. Stotter ◽  
Brianna E. Talbot ◽  
Diane E. Capen ◽  
Nadine Artelt ◽  
Junwei Zeng ◽  
...  
Keyword(s):  
Renal Failure ◽  
Glomerular Sclerosis ◽  
Tn Antigen ◽  
Foot Process Effacement ◽  
Hemizygous Male ◽  
Podocyte Loss ◽  
A Cell ◽  
Foot Process ◽  
Matrix Organization ◽  
The Stability

Mucin-type O-linked glycosylation, a posttranslational modification affecting the stability and biophysical characteristics of proteins, requires C1GalT1 (T synthase) and its obligate, X-linked chaperone Cosmc. Hypomorphic C1GalT1 mutations cause renal failure via not yet established mechanisms. We hypothesize that impaired Cosmc-dependent O-glycosylation in podocytes is sufficient to cause disease. Podocyte-specific Cosmc knockout mice were generated and phenotyped to test this hypothesis. Female heterozygous mice displaying mosaic inactivation of Cosmc in podocytes due to random X-linked inactivation were also examined. Mice with podocyte-specific Cosmc deletion develop profound albuminuria, foot process effacement, glomerular sclerosis, progressive renal failure, and impaired survival. Glomerular transcriptome analysis reveals early changes in cell adhesion, extracellular matrix organization, and chemokine-mediated signaling pathways, coupled with podocyte loss. Expression of the O-glycoprotein podoplanin was lost, while Tn antigen, representing immature O-glycans, was most abundantly found on podocalyxin. In contrast to hemizygous male and homozygous female animals, heterozygous female mosaic animals developed only mild albuminuria, focal foot process effacement, and nonprogressive kidney disease. Ultrastructurally, Cosmc-deficient podocytes formed Tn antigen-positive foot processes interdigitating with those of normal podocytes but not with other Cosmc-deficient cells. This suggests a cell nonautonomous mechanism for mucin-type O-glycoproteins in maintaining podocyte function. In summary, our findings demonstrated an essential and likely cell nonautonomous role for mucin-type O-glycosylation for podocyte function.

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