Bacteroides fragilis enterotoxin induces cyclooxygenase-2 and fluid secretion in intestinal epithelial cells through NF-κB activation

2006 ◽  
Vol 36 (9) ◽  
pp. 2446-2456 ◽  
Author(s):  
Jung Mogg Kim ◽  
Jin Young Lee ◽  
Young Mee Yoon ◽  
Yu-Kyoung Oh ◽  
Ju Seop Kang ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Bacteroides Fragilis ◽  
Fluid Secretion ◽  
Cyclooxygenase 2 ◽  
Intestinal Epithelial

Synergistic induction of cyclooxygenase-2 by gastrin and EGF in intestinal epithelial cells

2003 ◽  
Vol 124 (4) ◽  
pp. A14
Author(s):  
Ji-Zhong Cheng ◽  
Yan-Shi Guo ◽  
Mark R. Hellmich ◽  
Courtney M. Townsend
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Cyclooxygenase 2 ◽  
Intestinal Epithelial ◽  
Synergistic Induction

Methotrexate injury induces increased expression of cyclooxygenase-2 and prostaglandins in intestinal epithelial cells

2003 ◽  
Vol 124 (4) ◽  
pp. A597
Author(s):  
Frederick S. Huang ◽  
Yumei Ye ◽  
Felicitas L. Marquart ◽  
Dai H. Chung ◽  
B. Mark Evers
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Cyclooxygenase 2 ◽  
Intestinal Epithelial

scholarly journals Paracrine cyclooxygenase-2-mediated signalling by macrophages promotes tumorigenic progression of intestinal epithelial cells

Oncogene ◽  
2002 ◽  
Vol 21 (47) ◽  
pp. 7175-7186 ◽  
Author(s):  
Stanley CW Ko ◽  
Keith S Chapple ◽  
Gillian Hawcroft ◽  
P Louise Coletta ◽  
Alexander F Markham ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Cyclooxygenase 2 ◽  
Intestinal Epithelial

scholarly journals Human Intestinal Epithelial Cells Respond toCryptosporidium parvum Infection with Increased Prostaglandin H Synthase 2 Expression and Prostaglandin E2and F2α Production

1998 ◽  
Vol 66 (4) ◽  
pp. 1787-1790 ◽  
Author(s):  
Fabrice Laurent ◽  
Martin F. Kagnoff ◽  
Tor C. Savidge ◽  
Muriel Naciri ◽  
Lars Eckmann
Keyword(s):  
Epithelial Cells ◽  
Animal Species ◽  
Intestinal Epithelial Cells ◽  
Fluid Secretion ◽  
Prostaglandin E ◽  
Intestinal Epithelial ◽  
Prostaglandin H Synthase ◽  
Human Intestinal Epithelial Cells ◽  
Intestinal Fluid Secretion ◽  
Prostaglandin H

ABSTRACT Cryptosporidium parvum is an important cause of diarrhea in humans and several animal species. Prostaglandins play a central role in regulating intestinal fluid secretion in animal models of cryptosporidiosis, but their cellular sources and mechanisms of induction are unclear. Here, we show that C. parvuminfection directly activates prostaglandin H synthase 2 expression and prostaglandin E2 and F2α production in human intestinal epithelial cells.

scholarly journals Gastrin Stimulates Cyclooxygenase-2 Expression in Intestinal Epithelial Cells through Multiple Signaling Pathways

2002 ◽  
Vol 277 (50) ◽  
pp. 48755-48763 ◽  
Author(s):  
Yan-Shi Guo ◽  
Ji-Zhong Cheng ◽  
Gui-Fang Jin ◽  
J. Silvio Gutkind ◽  
Mark R. Hellmich ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Signaling Pathways ◽  
Intestinal Epithelial Cells ◽  
Cyclooxygenase 2 ◽  
Intestinal Epithelial ◽  
Multiple Signaling

scholarly journals Bacteroides fragilis Enterotoxin Induces Human β-Defensin-2 Expression in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinase/IκB Kinase/NF-κB-Dependent Pathway

2010 ◽  
Vol 78 (5) ◽  
pp. 2024-2033 ◽  
Author(s):  
Young Mee Yoon ◽  
Jin Young Lee ◽  
Doyoung Yoo ◽  
Young-Suk Sim ◽  
Young-Jeon Kim ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Bacteroides Fragilis ◽  
Mitogen Activated Protein Kinase ◽  
Mucosal Inflammation ◽  
Intestinal Epithelial ◽  
Iκb Kinase ◽  
Mitogen Activated Protein ◽  
Spontaneous Disappearance

ABSTRACT Enterotoxigenic Bacteroides fragilis (ETBF) produces an approximately 20-kDa heat-labile enterotoxin (BFT) that plays an essential role in mucosal inflammation. Although spontaneous disappearance of ETBF infection is common, little information is available on regulated expression of antibacterial factors in response to BFT stimulation. This study investigates the role of BFT in human β-defensin 2 (hBD-2) induction from intestinal epithelial cells. Stimulation of HT-29 and Caco-2 intestinal epithelial cell lines with BFT resulted in the induction of hBD-2. Activation of a reporter gene for hBD-2 was dependent on the presence of NF-κB binding sites. In contrast, suppression of AP-1 did not affect hBD-2 expression in BFT-stimulated cells. Inhibition of p38 mitogen-activated protein kinase (MAPK) using SB203580 and small interfering RNA (siRNA) transfection resulted in a significant reduction in BFT-induced IκB kinase (IKK)/NF-κB activation and hBD-2 expression. Our results suggest that a pathway including p38 MAPK, IKK, and NF-κB activation is required for hBD-2 induction in intestinal epithelial cells exposed to BFT, and may be involved in the host defense following infection with ETBF.

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