Investigation on Arsenic−Antimony‐ and Arsenic−Bismuth Bond Containing Interpnictogen Chain Molecules

SummaryRecombinant chimaeric molecules between tissue-type plasminogen activator (t-PA) and single chain urokinase-type plasminogen activator (scu-PA) or two chain urokinase-type plasminogen activator (tcu-PA) have intact enzymatic properties of scu-PA or tcu-PA towards natural and synthetic substrates (Nelles et al., J Biol Chem 1987; 262: 10855-10862). In the present study, we have compared the reactivity with inhibitors of both the single chain and two chain variants of recombinant u-PA and two recombinant chimaeric molecules between t-PA and scu-PA (t-PA/u-PA-s: amino acids 1-263 of t-PA and 144-411 of u-PA; t-PA/u-PA-e: amino acids 1-274 of t-PA and 138-411 of u-PA). Incubation with human plasma in the absence of a fibrin clot for 3 h at 37° C at equipotent concentrations (50% clot lysis in 2 h), resulted in significant fibrinogen breakdown (to about 40% of the normal value) for all two chain molecules, but not for their single chain counterparts. Preincubation of the plasminogen activators with plasma for 3 h at 37° C, resulted in complete inhibition of the fibrinolytic potency of the two chain molecules but did not alter the potency of the single chain molecules. Inhibition of the two chain molecules occurred with a t½ of approximately 45 min. The two chain variants were inhibited by the synthetic urokinase inhibitor Glu-Gly-Arg-CH2CCl with apparent second-order rate constants of 8,000-10,000 M−1s−1, by purified α2-antiplasmin with second-order rate constants of about 300 M−1s−1, and by plasminogen activator inhibitor-1 (PAI-1) with second-order rate constants of approximately 2 × 107 M−1s−1.It is concluded that the reactivity of single chain and two chain forms of t-PA/u-PA chimaers with inhibitors is very similar to that of the single and two chain forms of intact u-PA.

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Activity of the first interstellar comet 2I/Borisov around perihelion: results from Indian observatories

Monthly Notices of the Royal Astronomical Society ◽

10.1093/mnras/stab084 ◽

2021 ◽

Vol 502 (3) ◽

pp. 3491-3499

Author(s):

K Aravind ◽

Shashikiran Ganesh ◽

Kumar Venkataramani ◽

Devendra Sahu ◽

Dorje Angchuk ◽

...

Keyword(s):

Solar System ◽

Production Rate ◽

Rate Ratio ◽

Carbon Chain ◽

Astronomical Observatory ◽

Nucleus Size ◽

Chain Molecules ◽

Molecular Emission ◽

Imaging And Spectroscopy ◽

Gas Ratio

ABSTRACT Comet 2I/Borisov is the first true interstellar comet discovered. Here, we present results from observational programs at two Indian observatories, 2 m Himalayan Chandra Telescope at the Indian Astronomical Observatory, Hanle (HCT) and 1.2 m telescope at the Mount Abu Infrared Observatory (MIRO). Two epochs of imaging and spectroscopy were carried out at the HCT and three epochs of imaging at MIRO. We found CN to be the dominant molecular emission on both epochs, 2019 November 30 and December 22, at distances of rH = 2.013 and 2.031 au, respectively. The comet was inferred to be relatively depleted in Carbon bearing molecules on the basis of low C2 and C3 abundances. We find the production rate ratio, Q(C2)/Q(CN) = 0.54 ± 0.18, pre-perihelion and Q(C2)/Q(CN) = 0.34 ± 0.12 post-perihelion. This classifies the comet as being moderately depleted in carbon chain molecules. Using the results from spectroscopic observations, we believe the comet to have a chemically heterogeneous surface having variation in abundance of carbon chain molecules. From imaging observations, we infer a dust-to-gas ratio similar to carbon chain depleted comets of the Solar system. We also compute the nucleus size to be in the range 0.18 km ≤ r ≤ 3.1 km. Our observations show that 2I/Borisov’s behaviour is analogous to that of the Solar system comets.

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A proteoglycan form of heparin and its degradation to single-chain molecules.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)37973-5 ◽

1978 ◽

Vol 253 (19) ◽

pp. 6687-6693 ◽

Cited By ~ 28

Author(s):

H.C. Robinson ◽

A.A. Horner ◽

M. Höök ◽

S. Ogren ◽

U. Lindahl

Keyword(s):

Single Chain ◽

Chain Molecules

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Carbon-chain molecules in molecular outflows and Lupus I region – new producing region and new forming mechanism

Monthly Notices of the Royal Astronomical Society ◽

10.1093/mnras/stz1498 ◽

2019 ◽

Vol 488 (1) ◽

pp. 495-511

Author(s):

Yuefang Wu ◽

Xunchuan Liu ◽

Xi Chen ◽

Lianghao Lin ◽

Jinghua Yuan ◽

...

Keyword(s):

Radio Telescope ◽

Molecular Cloud ◽

Carbon Chain ◽

Species Range ◽

Chain Molecules ◽

Forming Mechanism ◽

Molecular Outflows ◽

Chemical Models ◽

Cloud Complex

Abstract Using the new equipment of the Shanghai Tian Ma Radio Telescope, we have searched for carbon-chain molecules (CCMs) towards five outflow sources and six Lupus I starless dust cores, including one region known to be characterized by warm carbon-chain chemistry (WCCC), Lupus I-1 (IRAS 15398-3359), and one TMC-1 like cloud, Lupus I-6 (Lupus-1A). Lines of HC3N J = 2 − 1, HC5N J = 6 − 5, HC7N J = 14 − 13, 15 − 14, 16 − 15, and C3S J = 3 − 2 were detected in all the targets except in the outflow source L1660 and the starless dust core Lupus I-3/4. The column densities of nitrogen-bearing species range from 1012 to 1014 cm−2 and those of C3S are about 1012 cm−2. Two outflow sources, I20582+7724 and L1221, could be identified as new carbon-chain-producing regions. Four of the Lupus I dust cores are newly identified as early quiescent and dark carbon-chain-producing regions similar to Lup I-6, which together with the WCCC source, Lup I-1, indicate that carbon-chain-producing regions are popular in Lupus I which can be regard as a Taurus-like molecular cloud complex in our Galaxy. The column densities of C3S are larger than those of HC7N in the three outflow sources I20582, L1221, and L1251A. Shocked carbon-chain chemistry is proposed to explain the abnormal high abundances of C3S compared with those of nitrogen-bearing CCMs. Gas-grain chemical models support the idea that shocks can fuel the environment of those sources with enough S+ thus driving the generation of S-bearing CCMs.

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