Interfering with the Sugar Code: Ten Years Later

2020 ◽  
Vol 2020 (30) ◽  
pp. 4652-4663 ◽  
Author(s):  
Anna Bernardi ◽  
Sara Sattin
Keyword(s):  
Sugar Code

scholarly journals Glycans in autophagy, endocytosis and lysosomal functions

2021 ◽  
Author(s):  
Fulvio Reggiori ◽  
Hans-Joachim Gabius ◽  
Massimo Aureli ◽  
Winfried Römer ◽  
Sandro Sonnino ◽  
...  
Keyword(s):  
Sugar Code ◽  
Endogenous Lectins ◽  
Biological Aspects ◽  
Molecular Signals ◽  
Lysosomal Proteins ◽  
In Cells

AbstractGlycans have been shown to function as versatile molecular signals in cells. This prompted us to look at their roles in endocytosis, endolysosomal system and autophagy. We start by introducing the cell biological aspects of these pathways, the concept of the sugar code, and provide an overview on the role of glycans in the targeting of lysosomal proteins and in lysosomal functions. Moreover, we review evidence on the regulation of endocytosis and autophagy by glycans. Finally, we discuss the emerging concept that cytosolic exposure of luminal glycans, and their detection by endogenous lectins, provides a mechanism for the surveillance of the integrity of the endolysosomal compartments, and serves their eventual repair or disposal.

scholarly journals What is the Sugar Code?

ChemBioChem ◽  
2021 ◽  
Author(s):  
Hans-Joachim Gabius ◽  
Maré Cudic ◽  
Tammo Diercks ◽  
Herbert Kaltner ◽  
Jürgen Kopitz ◽  
...  
Keyword(s):  
Sugar Code

Translating the ‘Sugar Code’ into Immune and Vascular Signaling Programs

2017 ◽  
Vol 42 (4) ◽  
pp. 255-273 ◽  
Author(s):  
Juan P. Cerliani ◽  
Ada G. Blidner ◽  
Marta A. Toscano ◽  
Diego O. Croci ◽  
Gabriel A. Rabinovich
Keyword(s):  
Sugar Code

scholarly journals Sia: The Sugar Code of Life

2018 ◽  
Vol 2 (2) ◽  
Author(s):  
Robert Skopec
Keyword(s):  
Sugar Code
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