The Electrochemical Behavior ofα-Ketoglutarate at the Hanging Mercury Drop Electrode in Acidic Aqueous Solution and Its Practical Application in Environmental and Biological Samples

2004 ◽  
Vol 16 (12) ◽  
pp. 1051-1058 ◽  
Author(s):  
Li Yang ◽  
Zhengbiao Yang ◽  
Min Zhang ◽  
Haiyan Ni ◽  
Ming Ji ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Electrochemical Behavior ◽  
Biological Samples ◽  
Hanging Mercury Drop Electrode ◽  
Practical Application ◽  
Acidic Aqueous Solution ◽  
Mercury Drop Electrode ◽  
Environmental And Biological Samples

Voltammetric behavior and quantification of the anti-leukemia drug imatinib in bulk form, pharmaceutical formulation, and human serum at a mercury electrode

2004 ◽  
Vol 82 (7) ◽  
pp. 1203-1209 ◽  
Author(s):  
E Hammam ◽  
H S El-Desoky ◽  
A Tawfik ◽  
M M Ghoneim
Keyword(s):  
Cyclic Voltammetry ◽  
Human Serum ◽  
Electrochemical Behavior ◽  
Stripping Voltammetry ◽  
Pharmaceutical Formulation ◽  
Myelogenous Leukemia ◽  
Hanging Mercury Drop Electrode ◽  
Square Wave ◽  
Mercury Drop Electrode ◽  
Square Wave Stripping Voltammetry

Imatinib (GleevecTM, ST1571) exemplifies the successful development of a rationally designed molecularly targeted therapy for treatment of a specific cancer. It is a highly promising new drug for the treatment of chronic myelogenous leukemia in blast crisis, in the accelerated or chronic phase after interferon failure or intolerance. The electrochemical behavior of imatinib was studied in Britton–Robinson (B–R) buffers of pH 2 to 11 by means of cyclic voltammetry at a hanging mercury drop electrode. The voltammograms showed a single 2-electron irreversible cathodic peak, which may be attributed to reduction of the C=O double bond of the imatinib molecule. Imatinib exhibited a strong adsorption onto the electrode surface especially in B–R buffers of pH 6 and 7. The adsorptive response of the drug was optimized with respect to the pH of the electrolysis medium, accumulation variables, and instrumental parameters using a square-wave stripping voltammetry technique. A fully validated, simple, sensitive, precise, and selective square-wave adsorptive cathodic stripping voltammetric procedure is described for trace determination of imatinib. The limits of detection (LOD) and quantitation (LOQ) of the bulk imatinib, following preconcentration for 150 s onto the hanging mercury drop electrode, were found to be 2.6 × 10–10 and 8.7 × 10–10 mol/L, respectively. The proposed procedure was successfully applied for quantitation of imatinib in pharmaceutical formulation (Glivec®) and spiked human serum, without the necessity for sample pretreatment or time-consuming extraction or evaporation steps prior to analysis of the drug. LOD and LOQ of 4.6 × 10–10 and 1.5 × 10–9 mol/L, respectively, were achieved after 120 s of preconcentration of the drug spiked in human serum.Key words: imatinib, GleevecTM, Glivec®, ST1571, cyclic voltammetry, square-wave stripping voltammetry, electrochemical behavior, quantification, pharmaceutical formulation, human serum.

Electrochemical behavior of 7-deazaguanine- and 7-deazaadenine-modified DNA at the hanging mercury drop electrode

2015 ◽  
Vol 147 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Zdenka Dudová ◽  
Jan Špaček ◽  
Martin Tomaško ◽  
Luděk Havran ◽  
Hana Pivoňková ◽  
...  
Keyword(s):  
Electrochemical Behavior ◽  
Hanging Mercury Drop Electrode ◽  
Mercury Drop Electrode ◽  
Modified Dna

The voltammetric determination of 4-nitrobiphenyl

1991 ◽  
Vol 56 (3) ◽  
pp. 595-601 ◽  
Author(s):  
Jiří Barek ◽  
Gulamustafa Malik ◽  
Jiří Zima
Keyword(s):  
Differential Pulse Voltammetry ◽  
Differential Pulse ◽  
Voltammetric Determination ◽  
Hanging Mercury Drop Electrode ◽  
Optimum Conditions ◽  
Mercury Drop Electrode ◽  
Working Electrode ◽  
Pulse Voltammetry ◽  
Unstirred Solution

Optimum conditions were found for the determination of 4-nitrobiphenyl by fast scan differential pulse voltammetry at a hanging mercury drop electrode in the concentration range 1 . 10-5 to 2 . 10-7 mol l-1. A further increase in sensitivity was attained by adsorptive accumulation of this substance on the surface of the working electrode, permitting determination in the concentration range (2 – 10) . 10-8 mol l-1 with one minute accumulation of the substance in unstirred solution or (2 – 10) . 10-9 mol l-1 with three-minute accumulation in stirred solution. Linear scan voltammetry can be used to determine 4-nitrobiphenyl in the concentration range (2 – 10) . 10-9 mol l-1 with five-minute accumulation in stirred solution, with the advantage of a smoother baseline and smaller interference from substances that yield only tensametric peaks.

The Application of Molecularly Imprinted Polymers to Solid-Phase Extraction

2014 ◽  
Vol 893 ◽  
pp. 283-286
Author(s):  
Hong Ying Pei ◽  
Gui Jun Shen ◽  
Yu Du
Keyword(s):  
Solid Phase Extraction ◽  
Molecularly Imprinted Polymers ◽  
Biological Samples ◽  
Solid Phase ◽  
Phase Extraction ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Structural Analogues ◽  
Environmental And Biological Samples

A benefit of imprinted polymers is the possibility to prepare sorbents with selectivity pre-determined for a particular substance, or group of structural analogues. The application most close to a wider acceptance is probably that of solid phase extraction for clean-up of environmental and biological samples. The technique of molecularly imprinted polymers to solid phase extraction (MISPE) is performance and high selectively, compared with traditional sorbents. In this paper, the preparation and application of MIPs would be reviewed.

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