scholarly journals Adrenal function during long‐term ACTH therapy for patients with developmental and epileptic encephalopathy

2021 ◽  
Author(s):  
Yuki Ueda ◽  
Shuta Fujishige ◽  
Takeru Goto ◽  
Shuhei Kimura ◽  
Noriko Namatame ◽  
...  
Keyword(s):  
Epileptic Encephalopathy ◽  
Adrenal Function ◽  
Acth Therapy

PITUITARY-ADRENAL FUNCTION IN RATS FOLLOWING LONG-TERM CORTISOL TREATMENT

1969 ◽  
Vol 61 (1_Suppl) ◽  
pp. S113
Author(s):  
J. R. Hodges ◽  
Janet Sadow
Keyword(s):  
Adrenal Function

Long-term developmental outcome after early hemispherotomy for hemimegalencephaly in infants with epileptic encephalopathy

2013 ◽  
Vol 29 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Ryoko Honda ◽  
Takanobu Kaido ◽  
Kenji Sugai ◽  
Akio Takahashi ◽  
Yuu Kaneko ◽  
...  
Keyword(s):  
Epileptic Encephalopathy ◽  
Developmental Outcome

Long-term triphenyltin exposure disrupts adrenal function in adult male rats

Chemosphere ◽  
2020 ◽  
Vol 243 ◽  
pp. 125149 ◽  
Author(s):  
Keyang Wu ◽  
Yang Li ◽  
Jianpeng Liu ◽  
Jiaying Mo ◽  
Xiaoheng Li ◽  
...  
Keyword(s):  
Adult Male ◽  
Adrenal Function ◽  
Male Rats

Effects of long-term hypoxemia on pituitary-adrenal function in fetal sheep

1996 ◽  
Vol 271 (4) ◽  
pp. E678-E685 ◽  
Author(s):  
J. Murotsuki ◽  
R. Gagnon ◽  
S. G. Matthews ◽  
J. R. Challis
Keyword(s):  
Adrenal Function ◽  
Arterial Oxygen ◽  
Pars Intermedia ◽  
Mrna Levels ◽  
Pars Distalis ◽  
Fetal Sheep ◽  
Fetal Plasma ◽  
Pomc Mrna ◽  
Pregnant Sheep

To test the hypothesis that long-term hypoxemia causes premature activation of the fetal pituitary-adrenal function, we embolized the fetal side of the placenta in pregnant sheep and examined the changes in concentrations of immunoreactive adrenocorticotropic hormone (irACTH), cortisol, and prostaglandin E2 (PGE2) in fetal plasma, and levels and localization of proopiomelanocortin (POMC) mRNA in the pars distalis and the pars intermedia of the fetal pituitary. Twelve fetal sheep were studied (6 embolized and 6 control) for 21 days between 0.74 and 0.88 of gestation. Daily injections of nonradiolabeled microspheres were given into the fetal abdominal aorta to decrease fetal arterial oxygen content by 40-50% of the preembolization values. In the embolized group, concentrations of irACTH, PGE2, and cortisol in fetal plasma increased gradually and were significantly (P < 0.05) elevated above those of controls after day 10, day 16, and day 20, respectively. POMC mRNA levels in the pars distalis of the fetal pituitary were not different from those of controls but were significantly reduced in the pars intermedia (P < 0.05). We conclude that levels of POMC mRNA in the pars distalis are unchanged during long-term hypoxemia possibly because of negative feedback effects of elevated cortisol on the pituitary gland. During long-term fetal hypoxemia, there is a differential regulation of POMC mRNA expression in the pars distalis and pars intermedia.

scholarly journals Effects of long term inhaled high dose beclomethasone dipropionate on adrenal function.

Thorax ◽  
1983 ◽  
Vol 38 (9) ◽  
pp. 676-681 ◽  
Author(s):  
M J Smith ◽  
M E Hodson
Keyword(s):  
Beclomethasone Dipropionate ◽  
Adrenal Function ◽  
High Dose

Effects of ewe size and nutrition during pregnancy on glucose metabolism, fat metabolism and adrenal function of postpubertal female twin offspring

2010 ◽  
Vol 50 (9) ◽  
pp. 869 ◽  
Author(s):  
D. S. van der Linden ◽  
P. R. Kenyon ◽  
H. T. Blair ◽  
N. Lopez-Villalobos ◽  
C. M. C. Jenkinson ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Fat Metabolism ◽  
Area Under The Curve ◽  
Major Effect ◽  
Adrenal Function ◽  
Metabolic Effects ◽  
Intravenous Insulin ◽  
Metabolic Functions ◽  
Ad Libitum

Little is known about the long-term metabolic effects of maternal constraint on the offspring and whether a possible interaction of dam size and nutrition during gestation exists, affecting postnatal metabolic functions in the offspring. Four hundred and fifty heavy (H) (60.8 ± 0.18 kg) and 450 light (L) (42.5 ± 0.17 kg) Romney dams were allocated to ad libitum (A) or maintenance (M) nutritional regimens under New Zealand pastoral grazing conditions, from Day 21 to 140 after insemination. One week before lambing, all dams and offspring were managed as one group and provided with ad libitum feeding. At 16 months of age, female twin-born offspring (n = 12 per size by nutrition group) were catheterised and given intravenous insulin (0.15 IU/kg) (ITT), glucose (0.17 g/kg) (GTT) and epinephrine (1 μg/kg) (ETT) challenges to assess their glucose and fat metabolism and adrenal function. No effects of dam size or interactions between dam size and dam nutrition were found on glucose or fat metabolism or adrenal function. In response to the ETT, M-dam offspring showed greater (P < 0.05) peak glucose concentrations, increased (P < 0.05) glucose area under the curve and tended (P < 0.10) to have increased maximum change in glucose and non-esterified free fatty acid concentrations compared with A-ewes. No effects of dam nutrition were found on glucose tolerance, insulin resistance or adrenal function in response to GTT and ITT. In conclusion, dam size had no effect on glucose metabolism, adrenal function or fat metabolism in 16-month-old female twin offspring. Dam nutrition during pregnancy from Day 21 to 140 had no major effect on glucose metabolism, adrenal function or lipolysis; however, it did potentially affect gluconeogenesis and/or glycogenolysis, as increased glucose concentrations in ewes born to M-fed dams were observed in response to ETT. These results indicate that M-ewes could have an advantage over A-ewes in physiological stressful situations in life (e.g. pregnancy, lactation) as their liver may be able to supply more glucose to support their growing conceptus and milk production to increase the chances of survival of their offspring.

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