A rapid and efficient one-pot method for the synthesis of 1-amidoalkyl-2-naphthols has been developed in the presence of mixed-addenda vanadium(V)-substituted polyoxomolybdates including: H3+xPMo12-xVxO40(x=1-3) heteropolyacids (HPAs) as recyclable catalysts under solvent-free conditions. In all cases heteropolyacid with x = 3 gave the highest yield under solvent-free conditions.
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An efficient four-component reaction to synthesize pyrrolo[2,1-a]isoquinolines from malononitrile, aromatic aldehydes, isoquinoline, and cyclohexyl isocyanide under solvent-free conditions is described. In a convenient, simple, and efficient one-pot procedure, the domino Knoevenagel-nucleophilic cycloaddition reaction affords excellent yields of products in less than 1 h.
One-pot, solvent-free synthesis via Biginelli reaction: Catalyst-free and new recyclable catalysts