Reply regarding prognostic value of neutrophil‐to‐lymphocyte ratio in laryngeal squamous cell carcinoma

Head & Neck ◽  
2017 ◽  
Vol 39 (3) ◽  
pp. 615-615
Author(s):  
B.Y. Winson Wong ◽  
Nicholas D. Stafford ◽  
Victoria L. Green ◽  
John Greenman
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals Prognostic value of the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma

Head & Neck ◽  
2015 ◽  
Vol 38 (S1) ◽  
pp. E1903-E1908 ◽  
Author(s):  
B. Y. Winson Wong ◽  
Nicholas D. Stafford ◽  
Victoria L. Green ◽  
John Greenman
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio

scholarly journals The Prognostic Value of Preoperative Plasma Fibrinogen and Neutrophil-to-Lymphocyte Ratio in Patients With Laryngeal Squamous Cell Carcinoma

2020 ◽  
pp. 014556132092074
Author(s):  
Hao Cai ◽  
Zi-Heng Zhang ◽  
Yu-Jie Zhou ◽  
Ji Liu ◽  
Huan-Qi Chen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Carcinoma ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Neutrophil To Lymphocyte Ratio ◽  
Plasma Fibrinogen ◽  
Optimal Cutoff ◽  
Lymphocyte Ratio ◽  
Cutoff Values

Objectives: Treatment effects in patients with laryngeal squamous cell carcinoma may vary significantly even among those with the same TNM stage. Routine preoperative blood and coagulation tests are economical and easily available hematological indicators. This study aimed to investigate the clinical predictive significance of pretreatment evaluation of plasma fibrinogen (FIB) level, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in patients with laryngeal carcinoma. Methods: Clinicopathological and demographic data from 203 patients who underwent surgery for laryngeal carcinoma were collected and analyzed. The optimal cutoff values for FIB, NLR, and PLR were determined using receiver operating characteristic curve analysis. Univariate and multivariate Cox regression analyses were used to study the relationship between blood markers and patient survival. Results: The optimal cutoff values for FIB, NLR, and PLR were 3.05 g/L, 2.41, and 110.94, respectively. Preoperative hyperfibrinemia (FIB >3.05 g/L) was an independent prognostic factor for overall survival (OS) and disease-free survival in patients with laryngeal carcinoma. An NLR >2.41 was associated with reduced OS in patients with laryngeal carcinoma, while PLR >110.94 had no effect on prognosis in these patients. Conclusions: Fibrinogen and NLR were valuable markers in predicting survival in patients with laryngeal carcinoma and may be used to inform clinicians in designing individual treatment strategies.

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