Outcomes of curative treatment for hepatocellular cancer in nonalcoholic steatohepatitis versus hepatitis C and alcoholic liver disease

Hepatology ◽  
2012 ◽  
Vol 55 (6) ◽  
pp. 1809-1819 ◽  
Author(s):  
Srinevas K. Reddy ◽  
Jennifer L. Steel ◽  
Hui-Wei Chen ◽  
David J. DeMateo ◽  
Jon Cardinal ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Alcoholic Liver Disease ◽  
Nonalcoholic Steatohepatitis ◽  
Hepatocellular Cancer ◽  
Curative Treatment

Liver

2020 ◽  
pp. 155-166
Author(s):  
Jad M. Abdelsattar ◽  
Moustafa M. El Khatib ◽  
T. K. Pandian ◽  
Samuel J. Allen ◽  
David R. Farley
Keyword(s):  
Blood Flow ◽  
Chronic Hepatitis ◽  
Liver Disease ◽  
Hepatitis C ◽  
Liver Failure ◽  
Abdominal Wall ◽  
Alcoholic Liver Disease ◽  
Nonalcoholic Steatohepatitis ◽  
Falciform Ligament ◽  
Ascites Tumors

The liver arises from the foregut-midgut junction. It is contained in the Glisson capsule, and the falciform ligament attaches the liver to the anterior abdominal wall. Hepatocytes perform approximately 500 functions. Chronic hepatitis C, alcoholic liver disease, and nonalcoholic steatohepatitis may cause cirrhosis and give rise to liver failure and potentially HCC. MRI, CT, and US are helpful for determining the extent of cirrhosis and detecting ascites, tumors, and blood flow. Fifty percent to 80% of the liver can be resected if the remainder functions well. Liver resections may bleed, leak bile, or lead to infection.

Proportion of Nonalcoholic Steatohepatitis in Patients with Chronic Liver Disease

2021 ◽  
Vol 15 (6) ◽  
pp. 1272-1274
Author(s):  
H.A. Abro ◽  
B. A. Shaikh ◽  
A. H. Mugheri ◽  
I. A. Ansari ◽  
Z. A. Shaikh ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Nonalcoholic Steatohepatitis ◽  
Smoking Status ◽  
Virus Hepatitis ◽  
B Virus

Aim: To determine the frequency of nonalcoholic steatohepatitis in patients with liver cirrhosis. Study Design: Retrospective/observational Place and Duration of Study: Department of Medicine, Chandka Medical College Hospital, Larkana from 1st July 2020 to 31st March 2021. Methodology: One hundred and twenty patients of both genders presented with liver cirrhosis were enrolled in this study. Patient’s detailed demographics including age, sex, body mass index, smoking status, alcohol consumption and family history of liver disease were recorded after taking written informed consent. Laboratory examination was done to examine the proportion of hepatitis B virus, hepatitis C virus and nonalcoholic steatohepatitis. Results: There were 68 (56.67%) males and 52 (43.33%) were females with mean age 45.74±10.54 years. Among all the patients hepatitis C virus was found in 62 (51.67%) patients, 15 (12.5%) had hepatitis B virus, 17 (14.17%) had hepatitis B virus + hepatitis C virus and nonalcoholic steatohepatitis was found in 26 (21.67%) patients. Conclusion: Nonalcoholic steatohepatitis was the major cause of liver cirrhosis in Pakistani population. The proportion of NASH in liver cirrhosis patients was 21.67%. Keywords: Nonalcoholic steatohepatitis (NASH), Liver Cirrhosis, Hepatitis B virus, Hepatitis C virus

scholarly journals Prevalence of the hemochromatosis gene mutation in patients with nonalcoholic steatohepatitis and correlation with degree of liver fibrosis

2006 ◽  
Vol 43 (3) ◽  
pp. 224-228 ◽  
Author(s):  
Idilio Zamin Jr ◽  
Angelo Alves de Mattos ◽  
Ângelo Zambam de Mattos ◽  
Eduardo Migon ◽  
Claudia Bica ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Iron Overload ◽  
Gene Mutation ◽  
Nonalcoholic Steatohepatitis ◽  
Elevated Serum ◽  
Inflammatory Activity ◽  
Control Group ◽  
Liver Iron ◽  
Hemochromatosis Gene

BACKGROUND: Nonalcoholic steatohepatitis is a chronic liver disease with a high prevalence in the general population and a potential to evolve into cirrhosis. It is speculated that iron overload could be associated with liver injury and unfavorable progress in affected patients. AIMS: To evaluate the prevalence of mutation of the hemochromatosis gene (HFE) in patients with nonalcoholic steatohepatitis and to correlate it with histological findings in liver specimens. PATIENTS AND METHODS: Twenty-nine patients with nonalcoholic steatohepatitis were evaluated. The presence of mutation in the hemochromatosis gene (C282Y and H63D) was tested in all patients and its result was evaluated in relation to hepatic inflammatory activity, presence of fibrosis, and iron overload in the liver. The control group was composed of 20 patients with normal liver function tests and 20 patients infected with the hepatitis C virus, with elevated serum levels of aminotransferases and with chronic hepatitis as shown by biopsy. RESULTS: Mutation of the hemochromatosis gene (C282Y and/or H63D) was diagnosed in 16 (55.2%) patients with nonalcoholic steatohepatitis, in 12 (60%) patients with hepatitis C and in 8 (40%) patients with no liver disease. No association was found between the presence of mutation and inflammatory activity, nor with the presence of fibrosis in patients with nonalcoholic steatohepatitis. An association was found between the presence of mutation and the occurrence of iron overload in liver, but there was no association between liver iron and the occurrence of fibrosis. CONCLUSIONS: The findings suggest that iron does not play a major role in the pathogenesis and progression of nonalcoholic steatohepatitis, and routine tests of the hemochromatosis gene mutation in these patients should not be recommended.

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