Liver

The liver arises from the foregut-midgut junction. It is contained in the Glisson capsule, and the falciform ligament attaches the liver to the anterior abdominal wall. Hepatocytes perform approximately 500 functions. Chronic hepatitis C, alcoholic liver disease, and nonalcoholic steatohepatitis may cause cirrhosis and give rise to liver failure and potentially HCC. MRI, CT, and US are helpful for determining the extent of cirrhosis and detecting ascites, tumors, and blood flow. Fifty percent to 80% of the liver can be resected if the remainder functions well. Liver resections may bleed, leak bile, or lead to infection.

POTENTIAL ANTITUMOR ACTIVITY STUDIES ON SOME COORDINATION COMPOUNDS OF RARE EARTH ELEMENTS WITH ANTIPYRINE

The aim of this study was to examine the anticancer activity of rare earth elements complexes with antipirin. Materials and methods. We have studied the cytotixic activity of in vitro and antineoplastic activity in vivo of 28 iodides and perchlorates containing as a ligand antipirine. Results. Here we show, that non of tested compounds exert cytotoxic action on 5 human cancer cell lines of different histogenesis at a concentration of 100 ßM. However, we observe that two complexes of antipirine derivatives with iodides of gadolinium and neodymium possess anti-tumor activity in experiments with transplantable solid tumors. Conclusion. The data obtained indicate the feasibility of further studies of these two complexes on a larger number of mice, with changing doses and routes of administration. We also suggest the investigation of these compounds on ascites tumors.

Long-Term Treatment with Aqueous Garlic and/or Tomato Suspensions Decreases Ehrlich Ascites Tumors

We evaluated the preventive and therapeutic effects of aqueous suspensions of garlic, tomato, and garlic + tomato in the development of experimental Ehrlich tumors in mice. The aqueous suspensions (2%) were administered over a short term for 30 days before tumor inoculation and 12 days afterward, and suspensions at 6% were administered for 180 days before inoculation and for 12 days afterward. The volume, number, and characteristics of the tumor cells and AgNOR counts were determined to compare the different treatments. Aqueous 6% suspensions of garlic, tomato, and garlic + tomato given over the long term significantly reduced tumor growth but when given over the short term, they did not alter tumor growth.