Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse

Hepatology ◽  
2012 ◽  
Vol 56 (2) ◽  
pp. 555-566 ◽  
Author(s):  
Akihito Okazaki ◽  
Nobuhiko Hiraga ◽  
Michio Imamura ◽  
C. Nelson Hayes ◽  
Masataka Tsuge ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Fas Ligand ◽  
Killer Cell ◽  
Human Hepatocyte ◽  
Chimeric Mouse ◽  
Ligand Interaction

scholarly journals Rat Spleen Dendritic Cells Express Natural Killer Cell Receptor Protein 1 (NKR-P1) and Have Cytotoxic Activity to Select Targets via a Ca2+-dependent Mechanism

1997 ◽  
Vol 186 (3) ◽  
pp. 467-472 ◽  
Author(s):  
Régis Josien ◽  
Michèle Heslan ◽  
Jean-Paul Soulillou ◽  
Maria-Cristina Cuturi
Keyword(s):  
Dendritic Cells ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Fas Ligand ◽  
Killer Cell ◽  
Cell Receptor ◽  
Receptor Protein ◽  
Natural Killer Cell Receptor ◽  
Major Function

Dendritic cells (DC) are a subset of leukocytes whose major function is antigen presentation. We investigated the phenotype and function of enriched (95–98.5%) rat DC. We show that both spleen and thymus DC express the natural killer cell receptor protein 1 (NKR-P1) as a disulfide linked homodimer of 60 kD. Freshly isolated DC express a low level of NKR-P1, which is strongly upregulated after overnight culture. Spleen, but not thymus DC, were able to kill the NK-sensitive YAC-1 cell line in vitro, and since this killing was Ca2+ dependent, a Fas ligand–Fas interaction was probably not involved. Besides their potent antigen-presenting function, DC can thus be cytotoxic for some tumor targets.

scholarly journals CD86 and IL-12p70 Are Key Players for T Helper 1 Polarization and Natural Killer Cell Activation by Toll-Like Receptor-Induced Dendritic Cells

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e44266 ◽  
Author(s):  
Felix S. Lichtenegger ◽  
Katharina Mueller ◽  
Bettina Otte ◽  
Barbara Beck ◽  
Wolfgang Hiddemann ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Cell Activation ◽  
Killer Cell ◽  
Toll Like Receptor ◽  
T Helper ◽  
T Helper 1 ◽  
Natural Killer Cell Activation ◽  
Key Players

IL-12 Production and Subsequent Natural Killer Cell Activation by Necrotic Tumor Cell-loaded Dendritic Cells in Therapeutic Vaccinations

2003 ◽  
Vol 3 (3) ◽  
pp. 188
Author(s):  
Aeyung Kim ◽  
Kwang Dong Kim ◽  
Seung-Chul Choi ◽  
Moon-Jin Jeong ◽  
Hee Gu Lee ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Natural Killer Cell ◽  
Tumor Cell ◽  
Natural Killer ◽  
Cell Activation ◽  
Killer Cell ◽  
Natural Killer Cell Activation ◽  
Necrotic Tumor

Escape of monocyte-derived dendritic cells of HIV-1 infected individuals from natural killer cell-mediated lysis

AIDS ◽  
2003 ◽  
Vol 17 (16) ◽  
pp. 2291-2298 ◽  
Author(s):  
Silvana Tasca ◽  
Giuseppe Tambussi ◽  
Silvia Nozza ◽  
Brunella Capiluppi ◽  
Maria Raffaella Zocchi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Hiv 1

scholarly journals Optimal culture conditions for the generation of natural killer cell-induced dendritic cells for cancer immunotherapy

2011 ◽  
Vol 9 (1) ◽  
pp. 45-53 ◽  
Author(s):  
Thanh-Nhan Nguyen-Pham ◽  
Deok-Hwan Yang ◽  
Truc-Anh Thi Nguyen ◽  
Mi-Seon Lim ◽  
Cheol Yi Hong ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Natural Killer Cell ◽  
Cancer Immunotherapy ◽  
Natural Killer ◽  
Killer Cell ◽  
Culture Conditions

scholarly journals Maraba MG1 Virus Enhances Natural Killer Cell Function via Conventional Dendritic Cells to Reduce Postoperative Metastatic Disease

2014 ◽  
Vol 22 (7) ◽  
pp. 1320-1332 ◽  
Author(s):  
Jiqing Zhang ◽  
Lee-Hwa Tai ◽  
Carolina S Ilkow ◽  
Almohanad A Alkayyal ◽  
Abhirami A Ananth ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Metastatic Disease ◽  
Cell Function ◽  
Killer Cell ◽  
Natural Killer Cell Function
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