scholarly journals Liver vitamin D receptor, CYP2R1, and CYP27A1 expression: relationship with liver histology and vitamin D3 levels in patients with nonalcoholic steatohepatitis or hepatitis C virus

Hepatology ◽  
2012 ◽  
Vol 56 (6) ◽  
pp. 2180-2187 ◽  
Author(s):  
Ilaria Barchetta ◽  
Simone Carotti ◽  
Giancarlo Labbadia ◽  
Umberto Vespasiani Gentilucci ◽  
Andrea Onetti Muda ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Vitamin D Receptor ◽  
Vitamin D3 ◽  
Nonalcoholic Steatohepatitis ◽  
Liver Histology ◽  
Liver Vitamin

scholarly journals 25-Hydroxyvitamin D Inhibits Hepatitis C Virus Production in Hepatocellular Carcinoma Cell Line by a Vitamin D Receptor-Independent Mechanism

2019 ◽  
Vol 20 (9) ◽  
pp. 2367 ◽  
Author(s):  
Amiram Ravid ◽  
Noa Rapaport ◽  
Assaf Issachar ◽  
Arie Erman ◽  
Larisa Bachmetov ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Vitamin D Receptor ◽  
Vitamin D3 ◽  
Mode Of Action ◽  
Virus Production ◽  
Independent Manner ◽  
Hydroxyvitamin D ◽  
Independent Mechanism

Previously, we have reported that the active vitamin D metabolite, calcitriol and vitamin D3 (cholecalciferol), both remarkably inhibit hepatitis C virus production. The mechanism by which vitamin D3 exerts its effect is puzzling due to the low levels of calcitriol produced in vitamin D3-treated Huh7.5 cells. In this study, we aimed to explore the mechanism of vitamin D3 anti-hepatitis C virus effect. We show that vitamin D3 activity is not mediated by its metabolic conversion to calcitriol, but may be due to its primary metabolic product 25(OH)D3. This is inferred from the findings that 25(OH)D3 could inhibit hepatitis C virus production in our system, and that adequate concentrations needed to exert this effect are produced in Huh7.5 cells treated with vitamin D3. Using the CRISPR-Cas9 editing technology to knockout the vitamin D receptor, we found that the antiviral activity of vitamin D3 and 25(OH)D3 was not impaired in the vitamin D receptor knockout cells. This result indicates that 25(OH)D3 anti-hepatitis C virus effect is exerted by a vitamin D receptor-independent mode of action. The possibility that vitamin D3 and 25(OH)D3, being 3β-hydroxysteroids, affect hepatitis C virus production by direct inhibition of the Hedgehog pathway in a vitamin D receptor-independent manner was ruled out. Taken together, this study proposes a novel mode of action for the anti-hepatitis C virus activity of vitamin D3 that is mediated by 25(OH)D3 in a vitamin D receptor-independent mechanism.

scholarly journals Autophagy, apoptosis, vitamin D, and vitamin D receptor in hepatocellular carcinoma associated with hepatitis C virus

Medicine ◽  
2018 ◽  
Vol 97 (12) ◽  
pp. e0172 ◽  
Author(s):  
Mohamed Ahmed Abdel-Mohsen ◽  
Ahlam Abd-Allah El-Braky ◽  
Abeer Abd El-Rahim Ghazal ◽  
Mohammed Mohammed Shamseya
Keyword(s):  
Hepatocellular Carcinoma ◽  
Vitamin D ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Vitamin D Receptor

Apa1 (rs7975232) SNP in the vitamin D receptor is linked to hepatocellular carcinoma in hepatitis C virus cirrhosis

2019 ◽  
Vol 77 (2) ◽  
pp. 53-57 ◽  
Author(s):  
I Raafat Rowida ◽  
KA Eshra ◽  
RM El-Sharaby ◽  
RAE Eissa ◽  
SM Saied ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Vitamin D ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Vitamin D Receptor

Genetic variations in vitamin D receptor were associated with the outcomes of hepatitis C virus infection among Chinese population

2015 ◽  
Vol 61 (2) ◽  
pp. 129-135 ◽  
Author(s):  
Meng-ping Wu ◽  
Jin-wei Zhang ◽  
Peng Huang ◽  
Ya-ping Han ◽  
Yun Zhang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Vitamin D Receptor ◽  
Chinese Population ◽  
Genetic Variations ◽  
Hepatitis C Virus Infection

A vitamin D receptor start codon polymorphism (T12022C) affects chronicity rate after exposure to hepatitis C virus and subsequent response to antiviral therapy

2003 ◽  
Vol 38 ◽  
pp. 215
Author(s):  
M. Wright ◽  
R. Goldin ◽  
R. Apple ◽  
L. Steiner ◽  
H. Thomas ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Therapy ◽  
Vitamin D Receptor ◽  
Start Codon ◽  
Subsequent Response

Vitamin D Receptor (VDR) Allelic Variants Correlating with Response to Vitamin D3 Supplementation in Breast Cancer Survivors

2021 ◽  
pp. 1-14
Author(s):  
Elham Kazemian ◽  
Sayed Hossein Davoodi ◽  
Mohammad Esmaeil Akbari ◽  
Nariman Moradi ◽  
Safoora Gharibzadeh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Survivors ◽  
Vitamin D Receptor ◽  
Vitamin D3 ◽  
Breast Cancer Survivors ◽  
Allelic Variants ◽  
Vitamin D3 Supplementation

Identification of a highly potent vitamin D receptor antagonist: (25S)-26-Adamantyl-25-hydroxy-2-methylene-22,23-didehydro-19,27-dinor-20-epi-vitamin D3 (ADMI3)

2007 ◽  
Vol 460 (2) ◽  
pp. 240-253 ◽  
Author(s):  
Miharu Igarashi ◽  
Nobuko Yoshimoto ◽  
Keiko Yamamoto ◽  
Masato Shimizu ◽  
Michiyasu Ishizawa ◽  
...  
Keyword(s):  
Vitamin D ◽  
Receptor Antagonist ◽  
Vitamin D Receptor ◽  
Vitamin D3

scholarly journals Vitamin D: An innate antiviral agent suppressing hepatitis C virus in human hepatocytes

Hepatology ◽  
2011 ◽  
Vol 54 (5) ◽  
pp. 1570-1579 ◽  
Author(s):  
Meital Gal-Tanamy ◽  
Larisa Bachmetov ◽  
Amiram Ravid ◽  
Ruth Koren ◽  
Arie Erman ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Agent ◽  
Human Hepatocytes
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