Elevated Fructose and Uric Acid Through Aldose Reductase Contribute to Experimental and Human Alcoholic Liver Disease

Hepatology ◽  
2020 ◽  
Vol 72 (5) ◽  
pp. 1617-1637 ◽  
Author(s):  
Min Wang ◽  
Wei‐Yang Chen ◽  
Jingwen Zhang ◽  
Leila Gobejishvili ◽  
Shirish S. Barve ◽  
...  
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Aldose Reductase ◽  
Alcoholic Liver Disease ◽  
Human Alcoholic

Conservation of whole body nitric oxide metabolism in human alcoholic liver disease: Implications for nitric oxide production

2006 ◽  
Vol 41 (7) ◽  
pp. 820-825 ◽  
Author(s):  
Eric A. G. Demoncheaux ◽  
David A. Elphick ◽  
Marc B. Dürner ◽  
Gail E. Higgins ◽  
David Crowther ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Whole Body ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Nitric Oxide Metabolism ◽  
Human Alcoholic

Changes of hepatic microtubules and secretory proteins in human alcoholic liver disease

1983 ◽  
Vol 18 ◽  
pp. 479-482 ◽  
Author(s):  
Yoshiro Matsuda ◽  
Akira Takada ◽  
Ryuichi Kanayama ◽  
Shujiro Takase
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Secretory Proteins ◽  
Human Alcoholic

Disturbed intracellular calcium-related processes of hepatocytes and neutrophils in human alcoholic liver disease

1990 ◽  
Vol 23 (3) ◽  
pp. 241-245 ◽  
Author(s):  
György Baffy ◽  
Zsuzsa Varga ◽  
Gabriella Fóris ◽  
András Leövey
Keyword(s):  
Liver Disease ◽  
Intracellular Calcium ◽  
Alcoholic Liver Disease ◽  
Human Alcoholic

Pathological significance of oxidative cellular damage in human alcoholic liver disease

2003 ◽  
Vol 42 (4) ◽  
pp. 365-371 ◽  
Author(s):  
S Seki ◽  
T Kitada ◽  
H Sakaguchi ◽  
K Nakatani ◽  
K Wakasa
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Cellular Damage ◽  
Human Alcoholic

The interleukin-17 pathway is involved in human alcoholic liver disease

Hepatology ◽  
2008 ◽  
Vol 49 (2) ◽  
pp. 646-657 ◽  
Author(s):  
Arnaud Lemmers ◽  
Christophe Moreno ◽  
Thierry Gustot ◽  
Raphaël Maréchal ◽  
Delphine Degré ◽  
...  
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Interleukin 17 ◽  
Human Alcoholic

scholarly journals Aldose Reductase Inhibitors of Plant Origin in the Prevention and Treatment of Alcoholic Liver Disease: A Minireview

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Longxin Qiu ◽  
Chang Guo ◽  
Baoyu Hua
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Liver Disease ◽  
Inflammatory Cytokines ◽  
Aldose Reductase ◽  
Alcoholic Liver Disease ◽  
Lipid Synthesis ◽  
Plant Origin ◽  
Reductase Inhibitors ◽  
Natural Medicine

Alcoholic liver disease (ALD) is caused by heavy alcohol consumption over a long period. Acetaldehyde-mediated toxicity, oxidative stress, and imbalance of lipid metabolism are generally considered involved in the initiation of ALD. There is an increasing requirement for alternative and natural medicine to treat ALD. Recently, aldose reductase (AR) has been reported to be involved in the development of ALD by affecting inflammatory cytokines, oxidative stress, and lipid metabolism. Here, we review the effect of plant-derived AR inhibitors on ALD in rodents. And we conclude that AR inhibitors of plant origin may enhance antioxidant capacity, inhibit lipid peroxidation and inflammatory cytokines expression, and activate AMP-activated protein kinase thereby subsequently suppressing alcohol-induced lipid synthesis in liver to achieve ALD protection. This review reveals that natural AR inhibitor may be potential therapeutic agent for ALD.

Increased S-Adenosylhomocysteine (SAH) May Predispose to TNF Liver Injury in Human Alcoholic Liver Disease (ALD)

2005 ◽  
Vol 100 ◽  
pp. S143
Author(s):  
Jonathan W. Goldstein ◽  
Theresa Chen ◽  
Rehan Khan ◽  
Jennifer Lanter ◽  
Shirish Barve ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Injury ◽  
Alcoholic Liver Disease ◽  
Human Alcoholic

209 Uric Acid-Activated NLRP3 Inflammasome Is a Therapeutic Target in Alcoholic Liver Disease

2013 ◽  
Vol 144 (5) ◽  
pp. S-938
Author(s):  
Jan Petrasek ◽  
Shashi Bala ◽  
Karen Kodys ◽  
Victoria Menashy ◽  
Matthew Barrieau ◽  
...  
Keyword(s):  
Uric Acid ◽  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Nlrp3 Inflammasome ◽  
Therapeutic Target

scholarly journals Inhibition of aldose reductase ameliorates alcoholic liver disease by activating AMPK and modulating oxidative stress and inflammatory cytokines

2017 ◽  
Vol 16 (3) ◽  
pp. 2767-2772 ◽  
Author(s):  
Changxuan Shi ◽  
Yuanfang Wang ◽  
Jing Gao ◽  
Si Chen ◽  
Xiangqian Zhao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Inflammatory Cytokines ◽  
Aldose Reductase ◽  
Alcoholic Liver Disease
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