Biopsy Pathology and Immunohistochemistry of a Case of Immune‐Mediated Drug‐Induced Liver Injury With Atabecestat

Hepatology ◽  
2020 ◽  
Author(s):  
Sandra De Jonghe ◽  
Daniel Weinstock ◽  
Jason Aligo ◽  
Kay Washington ◽  
Dean Naisbitt
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated

scholarly journals Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models

2021 ◽  
Vol 22 (9) ◽  
pp. 4557
Author(s):  
Alessio Gerussi ◽  
Ambra Natalini ◽  
Fabrizio Antonangeli ◽  
Clara Mancuso ◽  
Elisa Agostinetto ◽  
...  
Keyword(s):  
Liver Injury ◽  
Experimental Models ◽  
Clinical Event ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated ◽  
Liver Injuries ◽  
Immunological Mechanisms ◽  
Molecular Aspects ◽  
Therapeutic Tools

Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly because of its ability to present with a variety of phenotypes including that of autoimmune hepatitis or other immune mediated liver injuries. Limited diagnostic and therapeutic tools are available, mostly because its pathogenesis has remained poorly understood for decades. The recent scientific and technological advancements in genomics and immunology are paving the way for a better understanding of the molecular aspects of DILI. This review provides an updated overview of the genetic predisposition and immunological mechanisms behind the pathogenesis of DILI and presents the state-of-the-art experimental models to study DILI at the pre-clinical level.

scholarly journals Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh

2009 ◽  
Vol 2009 ◽  
pp. 1-8 ◽  
Author(s):  
Grace Guzman ◽  
Eric R. Kallwitz ◽  
Christina Wojewoda ◽  
Rohini Chennuri ◽  
Jamie Berkes ◽  
...  
Keyword(s):  
Liver Injury ◽  
Autoimmune Hepatitis ◽  
Plasma Cells ◽  
Hepatic Necrosis ◽  
Serum Markers ◽  
Black Cohosh ◽  
Herbal Supplement ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated

There are a growing number of cases detailing acute hepatic necrosis in patients taking black cohosh (Cimicifuga racemosa), an over-the-counter herbal supplement for management of menopausal symptoms. Our aim is to illustrate two cases of liver injury following the use of black cohosh characterized by histopathological features mimicking autoimmune hepatitis. Both patients reported black cohosh use for at least six months and had no evidence of another cause of liver disease. Their liver biopsies showed a component of centrilobular necrosis consistent with severe drug-induced liver injury. In addition, the biopsies showed characteristics of autoimmune-like liver injury with an interface hepatitis dominated by plasma cells. Although serum markers for autoimmune hepatitis were not particularly elevated, both patients responded to corticosteroids, supporting an immune-mediated component to the liver injury. Liver injury following the use of black cohosh should be included in the list of differential diagnoses for chronic hepatitis with features mimicking autoimmune hepatitis.

Immune-Mediated Drug-Induced Liver Injury

2013 ◽  
pp. 401-412 ◽  
Author(s):  
Einar S. Björnsson ◽  
Guruprasad P. Aithal
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated

scholarly journals Immune‐mediated drug‐induced liver injury secondary to Omeprazole: A case report

2020 ◽  
Vol 8 (12) ◽  
pp. 3421-3426 ◽  
Author(s):  
Sara Seife Hassen ◽  
Fateen Ata ◽  
Ammara Bint I Bilal ◽  
Mohamed Salih Ali ◽  
Mahir Petkar ◽  
...  
Keyword(s):  
Case Report ◽  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated

Profiles of Immune Cells and Reproduction of Immune-mediated Drug-induced Liver Injury

2015 ◽  
Vol 110 ◽  
pp. S871
Author(s):  
Yasuyuki Fujisaka ◽  
Yasuteru Kondo ◽  
Takamitsu Sasaki ◽  
Takayuki Kogure ◽  
Jun Inoue ◽  
...  
Keyword(s):  
Liver Injury ◽  
Immune Cells ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated

scholarly journals Severe immune-mediated drug-induced liver injury linked to ibandronate: A case report

2013 ◽  
Vol 59 (5) ◽  
pp. 1139-1142 ◽  
Author(s):  
Nicolas Goossens ◽  
Laurent Spahr ◽  
Laura Rubbia-Brandt
Keyword(s):  
Case Report ◽  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated

scholarly journals Immune-mediated Drug-induced Liver Injury Caused by Laninamivir Octanoate Hydrate

2019 ◽  
Vol 58 (17) ◽  
pp. 2501-2505 ◽  
Author(s):  
Toshihiro Kawaguchi ◽  
Teruko Arinaga-Hino ◽  
Motoki Shimizu ◽  
Ken Tanikawa ◽  
Takahiko Tokushige ◽  
...  
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated

Immune-Mediated Drug-Induced Liver Injury

2020 ◽  
pp. 491-504
Author(s):  
Einar S. Björnsson ◽  
Guruprasad Padur Aithal
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated

scholarly journals Sex Bias in Experimental Immune-Mediated, Drug-Induced Liver Injury in BALB/c Mice: Suggested Roles for Tregs, Estrogen, and IL-6

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e61186 ◽  
Author(s):  
Joonhee Cho ◽  
Lina Kim ◽  
Zhaoxia Li ◽  
Noel R. Rose ◽  
Monica Vladut Talor ◽  
...  
Keyword(s):  
Liver Injury ◽  
Sex Bias ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated
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