scholarly journals Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models

2021 ◽  
Vol 22 (9) ◽  
pp. 4557
Author(s):  
Alessio Gerussi ◽  
Ambra Natalini ◽  
Fabrizio Antonangeli ◽  
Clara Mancuso ◽  
Elisa Agostinetto ◽  
...  
Keyword(s):  
Liver Injury ◽  
Experimental Models ◽  
Clinical Event ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated ◽  
Liver Injuries ◽  
Immunological Mechanisms ◽  
Molecular Aspects ◽  
Therapeutic Tools

Drug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly because of its ability to present with a variety of phenotypes including that of autoimmune hepatitis or other immune mediated liver injuries. Limited diagnostic and therapeutic tools are available, mostly because its pathogenesis has remained poorly understood for decades. The recent scientific and technological advancements in genomics and immunology are paving the way for a better understanding of the molecular aspects of DILI. This review provides an updated overview of the genetic predisposition and immunological mechanisms behind the pathogenesis of DILI and presents the state-of-the-art experimental models to study DILI at the pre-clinical level.

Biopsy Pathology and Immunohistochemistry of a Case of Immune‐Mediated Drug‐Induced Liver Injury With Atabecestat

Hepatology ◽  
2020 ◽  
Author(s):  
Sandra De Jonghe ◽  
Daniel Weinstock ◽  
Jason Aligo ◽  
Kay Washington ◽  
Dean Naisbitt
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated

scholarly journals Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh

2009 ◽  
Vol 2009 ◽  
pp. 1-8 ◽  
Author(s):  
Grace Guzman ◽  
Eric R. Kallwitz ◽  
Christina Wojewoda ◽  
Rohini Chennuri ◽  
Jamie Berkes ◽  
...  
Keyword(s):  
Liver Injury ◽  
Autoimmune Hepatitis ◽  
Plasma Cells ◽  
Hepatic Necrosis ◽  
Serum Markers ◽  
Black Cohosh ◽  
Herbal Supplement ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated

There are a growing number of cases detailing acute hepatic necrosis in patients taking black cohosh (Cimicifuga racemosa), an over-the-counter herbal supplement for management of menopausal symptoms. Our aim is to illustrate two cases of liver injury following the use of black cohosh characterized by histopathological features mimicking autoimmune hepatitis. Both patients reported black cohosh use for at least six months and had no evidence of another cause of liver disease. Their liver biopsies showed a component of centrilobular necrosis consistent with severe drug-induced liver injury. In addition, the biopsies showed characteristics of autoimmune-like liver injury with an interface hepatitis dominated by plasma cells. Although serum markers for autoimmune hepatitis were not particularly elevated, both patients responded to corticosteroids, supporting an immune-mediated component to the liver injury. Liver injury following the use of black cohosh should be included in the list of differential diagnoses for chronic hepatitis with features mimicking autoimmune hepatitis.

Immune-Mediated Drug-Induced Liver Injury

2013 ◽  
pp. 401-412 ◽  
Author(s):  
Einar S. Björnsson ◽  
Guruprasad P. Aithal
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated

scholarly journals Immune‐mediated drug‐induced liver injury secondary to Omeprazole: A case report

2020 ◽  
Vol 8 (12) ◽  
pp. 3421-3426 ◽  
Author(s):  
Sara Seife Hassen ◽  
Fateen Ata ◽  
Ammara Bint I Bilal ◽  
Mohamed Salih Ali ◽  
Mahir Petkar ◽  
...  
Keyword(s):  
Case Report ◽  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated

Profiles of Immune Cells and Reproduction of Immune-mediated Drug-induced Liver Injury

2015 ◽  
Vol 110 ◽  
pp. S871
Author(s):  
Yasuyuki Fujisaka ◽  
Yasuteru Kondo ◽  
Takamitsu Sasaki ◽  
Takayuki Kogure ◽  
Jun Inoue ◽  
...  
Keyword(s):  
Liver Injury ◽  
Immune Cells ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated

scholarly journals Comparison of Liver Biopsy Findings with the Digestive Disease Week Japan 2004 Scale for Diagnosis of Drug-Induced Liver Injury

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Akemi Tsutsui ◽  
Yasuni Nakanuma ◽  
Kouichi Takaguchi ◽  
Satoko Nakamura ◽  
Hiroshi Shibata ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Biopsy ◽  
Digestive Disease ◽  
Drug Induced ◽  
Scale Evaluation ◽  
Drug Induced Liver Injury ◽  
Liver Injuries ◽  
Scale Scores ◽  
The Mean ◽  
Objective Tool

The liver biopsy remains a valuable tool in the diagnosis of drug-induced liver injury (DILI). The Digestive Disease Week Japan 2004 (DDW-J) scale proposed as an objective tool for the diagnosis of DILI has been widely used in Japan. So far, the histological features have not been compared with DDW-J scale in detail. Herein, we examined the correlation between liver biopsy findings and clinical features, particularly DDW-J scales. A total of 80 patients with liver injuries of unknown cause were enrolled. Based on the histological findings, these cases were categorized into 3 groups: A (DILI was strongly suspected), B (DILI was suspected), and C (DILI should be considered in the differential diagnosis). Histological groups and DDW-J scale were moderately correlated (κ=0.60). The mean total DDW-J scale scores were as follows: 4.89 for A, 3.26 for B, and 0.75 for C (p<0.05). While hepatocellular type was coincided in a majority of cases by histological and DDW-J scale evaluation, cholestatic type was not well coincided. In conclusion, biopsy findings and DDW-J scale were well correlated, and the hepatocellular type of liver injuries was well coincided by both evaluations, though there were several discrepant cases, particularly in cholestatic type.

scholarly journals The Immunological Mechanisms and Immune-Based Biomarkers of Drug-Induced Liver Injury

2021 ◽  
Vol 12 ◽  
Author(s):  
Wenhui Liu ◽  
Xiangchang Zeng ◽  
Yating Liu ◽  
Jinfeng Liu ◽  
Chaopeng Li ◽  
...  
Keyword(s):  
Immune Response ◽  
Liver Injury ◽  
New Drugs ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Cellular Events ◽  
Immunological Mechanisms ◽  
Close Relationship ◽  
Life Threatening ◽  
Underlying Mechanisms

Drug-induced liver injury (DILI) has become one of the major challenges of drug safety all over the word. So far, about 1,100 commonly used drugs including the medications used regularly, herbal and/or dietary supplements, have been reported to induce liver injury. Moreover, DILI is the main cause of the interruption of new drugs development and drugs withdrawn from the pharmaceutical market. Acute DILI may evolve into chronic DILI or even worse, commonly lead to life-threatening acute liver failure in Western countries. It is generally considered to have a close relationship to genetic factors, environmental risk factors, and host immunity, through the drug itself or its metabolites, leading to a series of cellular events, such as haptenization and immune response activation. Despite many researches on DILI, the specific biomarkers about it are not applicable to clinical diagnosis, which still relies on the exclusion of other causes of liver disease in clinical practice as before. Additionally, circumstantial evidence has suggested that DILI is mediated by the immune system. Here, we review the underlying mechanisms of the immune response to DILI and provide guidance for the future development of biomarkers for the early detection, prediction, and diagnosis of DILI.

scholarly journals Severe immune-mediated drug-induced liver injury linked to ibandronate: A case report

2013 ◽  
Vol 59 (5) ◽  
pp. 1139-1142 ◽  
Author(s):  
Nicolas Goossens ◽  
Laurent Spahr ◽  
Laura Rubbia-Brandt
Keyword(s):  
Case Report ◽  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Immune Mediated
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