Elevation of ?? T lymphocytes in peripheral blood and livers of patients with primary sclerosing cholangitis and other autoimmune liver diseases

Hepatology ◽  
1996 ◽  
Vol 23 (5) ◽  
pp. 988-993 ◽  
Author(s):  
E B Martins ◽  
A K Graham ◽  
R W Chapman ◽  
K A Fleming
Keyword(s):  
T Lymphocytes ◽  
Primary Sclerosing Cholangitis ◽  
Peripheral Blood ◽  
Liver Diseases ◽  
Sclerosing Cholangitis ◽  
Autoimmune Liver Diseases

The MELD score predicts the short-term and overall survival after liver transplantation in patients with primary sclerosing cholangitis or autoimmune liver diseases

2014 ◽  
Vol 399 (8) ◽  
pp. 1001-1009 ◽  
Author(s):  
Katrin Hoffmann ◽  
Ulf Hinz ◽  
Norbert Hillebrand ◽  
Tom Ganten ◽  
Daniel Gotthardt ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Overall Survival ◽  
Primary Sclerosing Cholangitis ◽  
Liver Diseases ◽  
Sclerosing Cholangitis ◽  
Meld Score ◽  
Short Term ◽  
Autoimmune Liver Diseases

scholarly journals CD4 + T cells from patients with primary sclerosing cholangitis exhibit reduced apoptosis and down-regulation of proapoptotic Bim in peripheral blood

2016 ◽  
Vol 101 (2) ◽  
pp. 589-597 ◽  
Author(s):  
Tanja Schoknecht ◽  
Dorothee Schwinge ◽  
Stephanie Stein ◽  
Christina Weiler-Normann ◽  
Marcial Sebode ◽  
...  
Keyword(s):  
T Cells ◽  
Primary Sclerosing Cholangitis ◽  
Peripheral Blood ◽  
Cd4 T Cells ◽  
Sclerosing Cholangitis ◽  
Down Regulation

scholarly journals Urisodeoxycholic Acid in Treatment of Liver Cirrhosis

2021 ◽  
Vol 9 (9) ◽  
pp. 1869-1873
Author(s):  
Sangale Mukta
Keyword(s):  
Liver Cirrhosis ◽  
Bile Acid ◽  
Primary Biliary Cirrhosis ◽  
Ursodeoxycholic Acid ◽  
Primary Sclerosing Cholangitis ◽  
Liver Diseases ◽  
Sclerosing Cholangitis ◽  
Chronic Liver ◽  
Biliary Cirrhosis ◽  
Chronic Liver Diseases

Abstract: Ursodeoxycholic acid is a dihy- droxy bile acid with a rapidly expanding spectrum of usage in acute and chronic liver diseases. The various mechanisms of action of this hydrophilic bile acid include direct cytoprotection, detergent action on dysfunctional microtubules, immunomodulation and induction of hypercholer- esis. Its efficacy in primary biliary cirrhosis and primary sclerosing cholangitis as an adjunct to medical therapy has been well established.Ursodeoxycholic acid prolongs survival in primary biliary cirrhosis and it improves biochemical parameters of cholestasis in various other cholestatic disorders including primary sclerosing cholangitis, intrahepatic cholestasis of pregnancy, cystic fibrosis and total parenteral nutritioninduced cholestasis. However, a positive effect on survival remains to be established in these diseases. Ursodeoxycholic acid is of unproven efficacy in non- cholestatic disorders such as acute rejection after liver transplantation, non-alcoholic steatohepatitis, alcoholic liver disease and chronic viral hepatitis. This review outlines the present knowledge of the Pharmacology of ursodeoxycholic acid, and presents data from clinical trials on its use in chronic liver diseases. Keywords: Liver cirrhosis, Urisodeoxycholic acid

scholarly journals Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis

JHEP Reports ◽  
2020 ◽  
Vol 2 (1) ◽  
pp. 100060 ◽  
Author(s):  
Michael Trauner ◽  
Yevgeniy Gindin ◽  
Zhaoshi Jiang ◽  
Chuhan Chung ◽  
G. Mani Subramanian ◽  
...  
Keyword(s):  
Disease Progression ◽  
Primary Sclerosing Cholangitis ◽  
Peripheral Blood ◽  
Sclerosing Cholangitis
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