A double-blind, placebo-controlled study of the effects of eptastigmine on scopolamine-induced cognitive deficits in healthy male subjects

1993 ◽  
Vol 8 (4) ◽  
pp. 271-278 ◽  
Author(s):  
C. R. Lines ◽  
J. H. Ambrose ◽  
A. Heald ◽  
M. Traub
2004 ◽  
Vol 171 (4S) ◽  
pp. 234-234 ◽  
Author(s):  
Harin Padma-Nathan ◽  
Jae Seung Pacik ◽  
Byoung Ok Ahn ◽  
Kyung Koo Kang ◽  
Mi Young Bahng ◽  
...  

1995 ◽  
Vol 9 (4) ◽  
pp. 195-198 ◽  
Author(s):  
Anil Minocha ◽  
Steven H Gallo

OBJECTIVE: To investigate the effect of erythromycin on orocecal transit time (OCTT) in 17 healthy male subjects in a double-blind, placebo controlled crossover trial.SUBJECTS AND METHODS: After an overnight fast, each subject received 250 mg erythromycin base, 500 mg erythromycin base or placebo on three different days. A standardized breakfast meal plus 20 g lactulose was administered 30 mins after ingestion of the test dose. Exhaled breath was collected and hydrogen concentration was assessed over 4 h. Hydrogen concentrations over time for each session were analyzed by a generalized logistic function generating a sigmoidal curve. The ‘front’ transit time (T1) was taken as the time when a sustained rise in breath hydrogen concentration was first observed. The midpoint from baseline to peak hydrogen concentration was denoted T2and represented the time when approximately half of the test meal had reached the cecum.RESULTS: There was no effect of erythromycin on OCTT. The T1(mean ± SEM) was 103.2±11.2, 103.3± 15.3 and 70.9±15.9 mins for placebo, 250 mg erythromycin base and 500 mg erythromycin base, respectively (P>0.05). Similarly, the T2was 113.3±11.3, 113.9± 16.5 and 99.3±15.3 mins for the three regimens.CONCLUSIONS: Oral administration of erythromycin does not alter OCTT in healthy male subjects.


1987 ◽  
Vol 17 (2) ◽  
pp. 329-333 ◽  
Author(s):  
Barbara Sahakian ◽  
Eileen Joyce ◽  
W. A. Lishman

SynopsisThe effects of physostigmine on test performance of a patient with multiple cognitive deficits were observed in a double-blind, placebo-controlled study. Scores on tests of learning and memory and tests of visuo-spatial and constructional ability were both improved by physostigmine, while lecithin improved scores only on the former tests.


Sign in / Sign up

Export Citation Format

Share Document