Acute administration of toluene affects memory retention in novel object recognition test and memory function-related gene expression in mice

2011 ◽  
Vol 32 (4) ◽  
pp. 300-304 ◽  
Author(s):  
Tin-Tin Win-Shwe ◽  
Hidekazu Fujimaki
Keyword(s):  
Gene Expression ◽  
Object Recognition ◽  
Memory Function ◽  
Novel Object Recognition ◽  
Acute Administration ◽  
Memory Retention ◽  
Related Gene ◽  
Object Recognition Test ◽  
Novel Object ◽  
Novel Object Recognition Test

Acute stress in adolescence vs early adulthood following selective deletion of dysbindin-1A: Effects on anxiety, cognition and other schizophrenia-related phenotypes

2019 ◽  
Vol 33 (12) ◽  
pp. 1610-1619 ◽  
Author(s):  
Lieve Desbonnet ◽  
Colm MP O’Tuathaigh ◽  
Clare O’Leary ◽  
Rachel Cox ◽  
Orna Tighe ◽  
...  
Keyword(s):  
Gene Expression ◽  
Object Recognition ◽  
Restraint Stress ◽  
Acute Stress ◽  
Novel Object Recognition ◽  
The Novel ◽  
Object Recognition Test ◽  
Novel Object ◽  
Acute Restraint Stress ◽  
Novel Object Recognition Test

Background: As exposure to stress has been linked to the onset and maintenance of psychotic illness, its pathogenesis may involve environmental stressors interacting with genetic vulnerability. Aim: To establish whether acute stress interacts with a targeted mutation of the gene encoding the neurodevelopmental factor dystrobrevin-binding protein 1 (DTNBP1), resulting in a specific loss of the isoform dysbindin-1A, to influence schizophrenia-relevant phenotypes in mice during adolescence and adulthood. Methods: Male and female mice with a heterozygous or homozygous deletion of DTNBP1 were assessed in the open field test following acute restraint stress in adolescence (Day 35) and young adulthood (Day 60–70). Effects of acute restraint stress on memory retention in the novel object recognition test was also assessed in adulthood. Baseline corticosterone was measured in serum samples and, brain-derived neurotrophic factor (BDNF), glucocorticoid and mineralocorticoid receptor gene expression levels were measured in the hippocampus of adult mice. Results: In the open field, deletion of dysbindin-1A induced hyperactivity and attenuated the action of stress to reduce hyperactivity in adolescence but not in adulthood; in females deletion of dysbindin-1A attenuated the effect of acute stress to increase anxiety-related behaviour in adolescence but not in adulthood. In the novel object recognition test, deletion of dysbindin-1A impaired memory and also revealed an increase in anxiety-related behaviour and a decrease in hippocampal BDNF gene expression in males. Conclusions: These data suggest that deletion of dysbindin-1A influences behaviours related to schizophrenia and anxiety more robustly in adolescence than in adulthood and that dysbindin-1A influences stress-related responses in a sex-dependent manner.

scholarly journals NAAG peptidase inhibitors and deletion of NAAG peptidase gene enhance memory in novel object recognition test

2013 ◽  
Vol 701 (1-3) ◽  
pp. 27-32 ◽  
Author(s):  
Karolina J. Janczura ◽  
Rafal T. Olszewski ◽  
Tomasz Bzdega ◽  
Dean J. Bacich ◽  
Warren D. Heston ◽  
...  
Keyword(s):  
Object Recognition ◽  
Recognition Test ◽  
Novel Object Recognition ◽  
Object Recognition Test ◽  
Novel Object ◽  
Peptidase Inhibitors ◽  
Novel Object Recognition Test ◽  
Naag Peptidase

scholarly journals Galanin (1–15)-fluoxetine interaction in the novel object recognition test. Involvement of 5-HT1A receptors in the prefrontal cortex of the rats

2019 ◽  
Vol 155 ◽  
pp. 104-112 ◽  
Author(s):  
Antonio Flores-Burgess ◽  
Carmelo Millón ◽  
Belen Gago ◽  
Laura García-Durán ◽  
Noelia Cantero-García ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Object Recognition ◽  
Recognition Test ◽  
Fluoxetine Interaction ◽  
Novel Object Recognition ◽  
The Novel ◽  
Object Recognition Test ◽  
Novel Object ◽  
Novel Object Recognition Test

scholarly journals Social State Influences Memory in Novel Object Recognition Test Through Oxidative Stress Balance in Male Rats

2018 ◽  
Vol 8 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Hamidreza Famitafreshi ◽  
Morteza Karimian
Keyword(s):  
Oxidative Stress ◽  
Prefrontal Cortex ◽  
Object Recognition ◽  
Recognition Test ◽  
Memory Performance ◽  
Novel Object Recognition ◽  
Object Recognition Test ◽  
Novel Object ◽  
Novel Object Recognition Test ◽  
Nitrite Nitrate

Objective:Social isolation is associated with adverse effects on brain functions. According to previous studies, the reduction of oxidative stress improves cognitive functions. Memory performance is dependent on hippocampus and prefrontal function. The aim of this study is to show that impairment of memory in object recognition test in isolation state is accompanied by deregulation of oxidative stress balance in related areas.Methods and Materials:In this study, 14 male Sprague-Dawley rats were randomly divided into two groups as follows: social and isolation. Socialization and isolation plus one week of acclimatization occurred for fourteen days. At the end of the study, after performing behavioral test, (novel object recognition test) rats were anesthetized and sacrificed. After preparation of tissues in controlled condition, oxidative stress status in hippocampus and prefrontal cortex for Malondialdehyde (MDA), glutathione and nitrite/nitrate was assessed.Results:MDA in the hippocampus and prefrontal cortex was higher in isolated rats compared to social rats. Glutathione and nitrite/nitrate in the hippocampus and prefrontal cortex were lower in isolated rats compared to social rats. Memory performance in novel object recognition test both in short term and long term was better in social rats.Conclusion:Memory performance in novel object recognition test is influenced by social and oxidative stress status. So improving memory is possible through socialization and improvement of antioxidant status.

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