A biodegradable copolymer for the slow release of growth hormone expedites scarring in diabetic rats

2007 ◽  
Vol 81B (2) ◽  
pp. 291-304 ◽  
Author(s):  
Francisco García-Esteo ◽  
Gemma Pascual ◽  
Alberto Gallardo ◽  
Julio San-Román ◽  
Julia Buján ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Slow Release ◽  
Diabetic Rats ◽  
Biodegradable Copolymer

Somatomedin inhibitors in serum and liver of growth hormone-deficient diabetic rats

Diabetes ◽  
1983 ◽  
Vol 32 (3) ◽  
pp. 262-264 ◽  
Author(s):  
R. Vassilopoulou-Sellin ◽  
C. O. Oyedeji ◽  
N. A. Samaan
Keyword(s):  
Growth Hormone ◽  
Diabetic Rats ◽  
Somatomedin Inhibitors

Slow release of insulin from a biodegradable matrix implanted in diabetic rats

Diabetes ◽  
1983 ◽  
Vol 32 (5) ◽  
pp. 478-481 ◽  
Author(s):  
M. F. Goosen ◽  
Y. F. Leung ◽  
G. M. O'Shea ◽  
S. Chou ◽  
A. M. Sun
Keyword(s):  
Slow Release ◽  
Diabetic Rats

Effects of refeeding of undernourished and insulin treatment of diabetic neonatal rats on IGF and IGFBP

1996 ◽  
Vol 271 (2) ◽  
pp. E223-E231 ◽  
Author(s):  
L. Goya ◽  
F. Rivero ◽  
M. A. Martin ◽  
R. Arahuetes ◽  
E. R. Hernandez ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Growth Factor ◽  
Mrna Expression ◽  
Insulin Treatment ◽  
Diabetic Rats ◽  
Insulin Like Growth Factor ◽  
Neonatal Rats ◽  
Igf I ◽  
Serum Gh

The effect of refeeding and insulin treatment of undernourished and diabetic neonatal rats, respectively, on the regulation of insulin-like growth factor (IGF) and insulin-like growth factor binding protein (IGFBP) was investigated. The changes in body weight, insulinemia, glycemia, serum IGF-I, and growth hormone (GH) as well as the increase of the 30-kDa IGFBP in undernourished and diabetic neonatal rats previously shown elsewhere were reversed by refeeding and insulin treatment, respectively. Also, changes in liver mRNA expression of IGF-I and-II and IGFBP-1 and -2 were restored in refed undernourished and IGF-I and IGFBP-1 levels recovered in insulin-treated diabetic rats. However, serum GH was still below normal after rehabilitation in both situations. Thus the present results support the idea of a GH-independent IGF/ IGFBP regulation mediated by a balance of insulin and nutrients as has already been suggested in previous neonatal studies.

scholarly journals Long-acting Insulin: Slow Release of Insulin from a Biodegradable Matrix Implanted in Diabetic Rats

Diabetes ◽  
1983 ◽  
Vol 32 (5) ◽  
pp. 478-481 ◽  
Author(s):  
M. F. A. Goosen ◽  
Y. F. Leung ◽  
G. M. O'Shea ◽  
S. Chou ◽  
A. M. Sun
Keyword(s):  
Slow Release ◽  
Diabetic Rats ◽  
Acting Insulin ◽  
Long Acting

Altered release of growth hormone from dispersed adenohypophysial cells of streptozotocin diabetic rats. II. Effects of a phorbol ester and secretagogues which increase cyclic AMP

1989 ◽  
Vol 67 (10) ◽  
pp. 1321-1325
Author(s):  
M. S. Sheppard ◽  
B. A. Eatock ◽  
R. M. Bala
Keyword(s):  
Growth Hormone ◽  
Cyclic Amp ◽  
Phorbol Ester ◽  
Phosphodiesterase Inhibitor ◽  
Adenosine Monophosphate ◽  
Diabetic Rats ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Growth Hormone Releasing Factor ◽  
Streptozotocin Diabetic Rats

We have shown in the companion paper that somatotrophs dispersed from streptozotocin diabetic rats exhibit altered sensitivity to the natural hypothalamic controlling hormones, growth hormone releasing factor and somatostatin. We have further studied the effects on growth hormone release from dispersed adenohypophysial cells of normal and streptozotocin diabetic rats of stimulation by compounds that increase cyclic 3′,5′-adenosine monophosphate formation or inhibit its breakdown and of a phorbol ester. The cells of the diabetic rats had no change in sensitivity in response to either cholera toxin or forskolin. A phosphodiesterase inhibitor caused an equal GH release from cells of both diabetic and normal animals after 60 min of incubation. There was no change in sensitivity of the cells of diabetic animals or in the maximal reponse of these cells to the phorbol ester 12-O-tetradecanoylphorbol 13-acetate when compared with normal cells. A low calcium medium that blocked growth hormone releasing factor stimulated growth hormone release from normal rat cells also blocked it from the cells of the diabetic rats. These results suggest that the defect in response of the somatotrophs of diabetic animals is specific and only occurs with the hypothalamic hormones and not with other secretagogues.Key words: growth hormone, diabetes, streptozotocin, cyclic AMP, phorbol ester.

Sign in / Sign up

Export Citation Format

Share Document