Suppression of mesangial cell proliferation and extracellular matrix production in streptozotocin-induced diabetic rats by Sp1 decoy oligodeoxynucleotide in vitro and in vivo

2008 ◽  
Vol 103 (2) ◽  
pp. 663-674 ◽  
Author(s):  
Jeong Han Kang ◽  
Young-Mi Chae ◽  
Kwan-Kyu Park ◽  
Cheorl-Ho Kim ◽  
In-Seon Lee ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Proliferation ◽  
Mesangial Cell ◽  
Diabetic Rats ◽  
Extracellular Matrix Production ◽  
Mesangial Cell Proliferation ◽  
Matrix Production

scholarly journals Anti-angiogenic compound (TNP-470) inhibits mesangial cell proliferation in vitro and in vivo

1997 ◽  
Vol 51 (6) ◽  
pp. 1838-1846 ◽  
Author(s):  
Masashi Haraguchi ◽  
Mikio Okamura ◽  
Masayo Konishi ◽  
Yoshio Konishi ◽  
Nobuo Negoro ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mesangial Cell ◽  
Mesangial Cell Proliferation ◽  
Proliferation In Vitro

scholarly journals Inhibition of mesangial cell proliferation by E2F decoy oligodeoxynucleotide in vitro and in vivo.

1998 ◽  
Vol 101 (11) ◽  
pp. 2589-2597 ◽  
Author(s):  
Y Maeshima ◽  
N Kashihara ◽  
T Yasuda ◽  
H Sugiyama ◽  
T Sekikawa ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mesangial Cell ◽  
Mesangial Cell Proliferation

scholarly journals Role of interleukin-6 in mediating mesangial cell proliferation and matrix production in vivo

1997 ◽  
Vol 51 (1) ◽  
pp. 69-78 ◽  
Author(s):  
Frank Eitner ◽  
Ralf Westerhuis ◽  
Michael Burg ◽  
Birgit Weinhold ◽  
Hermann-Josef Gröne ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Interleukin 6 ◽  
Mesangial Cell ◽  
Mesangial Cell Proliferation ◽  
Matrix Production

scholarly journals Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor.

1992 ◽  
Vol 175 (5) ◽  
pp. 1413-1416 ◽  
Author(s):  
R J Johnson ◽  
E W Raines ◽  
J Floege ◽  
A Yoshimura ◽  
P Pritzl ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Proliferation ◽  
Growth Factor ◽  
Wound Repair ◽  
Mesangial Cell ◽  
Platelet Derived Growth Factor ◽  
Inflammatory Conditions ◽  
Mesangial Cell Proliferation ◽  
Matrix Expansion

Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells in culture, is expressed in vivo in a variety of inflammatory conditions associated with cell proliferation, including atherosclerosis, wound repair, pulmonary fibrosis, and glomerulonephritis. However, it is not known if PDGF mediates the fibroproliferative responses that characterize these inflammatory disorders. We administered neutralizing anti-PDGF IgG or control IgG to rats with mesangial proliferative nephritis. Inhibition of PDGF resulted in a significant reduction in mesangial cell proliferation, and largely prevented the increased deposition of extracellular matrix associated with the disease. This suggests that PDGF may have a central role in proliferative glomerular disease.

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