Heat shock protein 70 modulates neural progenitor cells dynamics in human neuroblastoma SH‐SY5Y cells exposed to high glucose content

2018 ◽  
Vol 119 (8) ◽  
pp. 6482-6491 ◽  
Author(s):  
Leila Salimi ◽  
Reza Rahbarghazi ◽  
Vahab Jafarian ◽  
Çıgır Biray Avci ◽  
Bakiye Goker Bagca ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Progenitor Cells ◽  
High Glucose ◽  
Heat Shock Protein 70 ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Human Neuroblastoma ◽  
Glucose Content

High Glucose Content Abrogated the Normal Activity of Heat Shock Protein Signaling Pathway in Human Neuroblastoma Cells

2020 ◽  
Vol 51 (2) ◽  
pp. 180-184
Author(s):  
Leila Salimi ◽  
Sadegh Salarinasab ◽  
Reza Rahbarghazi ◽  
Alireza Nourazarian ◽  
Masoud Nikanfar ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Signaling Pathway ◽  
High Glucose ◽  
Neuroblastoma Cells ◽  
Normal Activity ◽  
Protein Signaling ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Glucose Content

scholarly journals miR-16-1 Promotes the Aberrantα-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Zhelin Zhang ◽  
Yan Cheng
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Parkinson Disease ◽  
Heat Shock Protein 70 ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line ◽  
Hsp70 Expression ◽  
Human Neuroblastoma Cell ◽  
Human Neuroblastoma ◽  
Human Neuroblastoma Cell Line

There is striking evidence that heat shock protein 70 (Hsp70) negatively regulatesα-synuclein aggregation, which plays a significant role in the formation and progression of Parkinson disease (PD). However, how the Hsp70 in neurons fails to prevent or even reverseα-synuclein aggregation and toxicity in PD still remains to be determined. In the present study, we constructed anα-synuclein-overexpressed human neuroblastoma cell line, SH-SY5Y-Syn, in which the blockage of Hsp70 promotedα-synuclein aggregation. And we also found that miR-16-1 downregulated Hsp70 and promotedα-synuclein aggregation in the SH-SY5Y-Syn cells. This study revealed a novel regulatory mechanism of Hsp70 expression, which might contribute to the PD development.

Down Modulation of N-myc, Heat-Shock Protein 70, and Nucleolin during the Differentiation of Human Neuroblastoma Cells1

1991 ◽  
Vol 110 (1) ◽  
pp. 146-150 ◽  
Author(s):  
Tadamasa Murakami ◽  
Hisamitsu Ohmori ◽  
Sadao Gotoh ◽  
Tohru Tsuda ◽  
Ryoichi Ohya ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Human Neuroblastoma

scholarly journals High glucose alters the DNA methylome in human neural progenitor cells

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S466
Author(s):  
Thameem Dheen ◽  
Deepika Kandilya ◽  
Sukanya Shyamasundar ◽  
Dhiraj Kumar Singh ◽  
Karthik Mallilankaraman ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
High Glucose ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Dna Methylome ◽  
Human Neural Progenitor Cells

Thiopental protects human neuroblastoma cells from apoptotic cell death — Potential role of heat shock protein 70

Life Sciences ◽  
2015 ◽  
Vol 139 ◽  
pp. 40-45 ◽  
Author(s):  
Martin Roesslein ◽  
Christian Froehlich ◽  
Verena Miltenberger ◽  
Felix Ulbrich ◽  
Ulrich Goebel ◽  
...  
Keyword(s):  
Cell Death ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Potential Role ◽  
Apoptotic Cell ◽  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma

High glucose induces apoptosis in embryonic neural progenitor cells by a pathway involving protein PKCδ

2011 ◽  
Vol 23 (8) ◽  
pp. 1366-1374 ◽  
Author(s):  
Shangming Liu ◽  
Qiuhuan Yuan ◽  
Shidou Zhao ◽  
Jingjing Wang ◽  
Yuji Guo ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
High Glucose ◽  
Neural Progenitor Cells ◽  
Neural Progenitor

Ammonia aggravates emotional stress-induced gastric mucosal oxidative injury through the cancellation of heat shock protein 70 (HSP70)

2001 ◽  
Vol 120 (5) ◽  
pp. A152-A152
Author(s):  
H SUZUKI ◽  
S NAGAHASHI ◽  
M MIYAZAWA ◽  
M MORI ◽  
H NAGATA ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Emotional Stress ◽  
Heat Shock Protein 70 ◽  
Oxidative Injury
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