Ab initio study of catalyzed and uncatalyzed amide bond formation as a model for peptide bond formation: Ammonia-Glycine reactions

1983 ◽  
Vol 4 (4) ◽  
pp. 449-460 ◽  
Author(s):  
Tetsuro Oie ◽  
Gilda H. Loew ◽  
Stanley K. Burt ◽  
Robert D. Macelroy
Keyword(s):  
Ab Initio ◽  
Bond Formation ◽  
Peptide Bond ◽  
Amide Bond ◽  
Ab Initio Study ◽  
Peptide Bond Formation ◽  
Amide Bond Formation

scholarly journals Unwanted hydrolysis or α/β-peptide bond formation: how long should the rate-limiting coupling step take?

RSC Advances ◽  
2019 ◽  
Vol 9 (53) ◽  
pp. 30720-30728 ◽  
Author(s):  
Viktória Goldschmidt Gőz ◽  
Adrienn Nagy ◽  
Viktor Farkas ◽  
Ernő Keszei ◽  
András Perczel
Keyword(s):  
Amino Acids ◽  
Bond Formation ◽  
Side Reaction ◽  
Peptide Bond ◽  
Amide Bond ◽  
Peptide Bond Formation ◽  
Active Esters ◽  
Amide Bond Formation ◽  
Rate Limiting ◽  
Hydrolysis Of

Parallel to the amide bond formation, the hydrolysis of the active esters of α/β-amino acids, as an unwanted side reaction limiting coupling efficacy, is studied.

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