scholarly journals JC virus load in cerebrospinal fluid and transcriptional control region rearrangements may predict the clinical course of progressive multifocal leukoencephalopathy

2012 ◽  
Vol 227 (10) ◽  
pp. 3511-3517 ◽  
Author(s):  
Serena Delbue ◽  
Francesca Elia ◽  
Camilla Carloni ◽  
Eleonora Tavazzi ◽  
Enrico Marchioni ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Progressive Multifocal Leukoencephalopathy ◽  
Control Region ◽  
Transcriptional Control ◽  
Clinical Course ◽  
Jc Virus ◽  
Virus Load ◽  
Transcriptional Control Region

scholarly journals Progressive multifocal leukoencephalopathy in human immunodeficiency virus type 1-infected patients: absence of correlation between JC virus neurovirulence and polymorphisms in the transcriptional control region and the major capsid protein loci

2001 ◽  
Vol 82 (4) ◽  
pp. 899-907 ◽  
Author(s):  
Monica Sala ◽  
Jean-Pierre Vartanian ◽  
Pascale Kousignian ◽  
Jean-François Delfraissy ◽  
Yassine Taoufik ◽  
...  
Keyword(s):  
Progressive Multifocal Leukoencephalopathy ◽  
Capsid Protein ◽  
Control Region ◽  
Transcriptional Control ◽  
Major Capsid Protein ◽  
Demyelinating Disease ◽  
Jc Virus ◽  
Capsid Protein Gene ◽  
Transcriptional Control Region ◽  
Genomic Marker

Progressive multifocal leukoencephalopathy (PML) is a rapidly fatal demyelinating disease of the central nervous system related to JC polyomavirus (JCV) replication in oligodendrocytes. PML usually occurs in immunocompromised individuals, especially in the setting of AIDS. Administration of highly active anti-retroviral therapy (HAART) may improve survival prognosis in some, but not all, patients with AIDS-related PML. This observation might be explained by the outgrowth of some JCV variants of increased fitness. To evaluate this hypothesis, two subgroups of five patients with AIDS-related PML, started on HAART after PML diagnosis, were analysed. The non-responder (NR) patients died rapidly despite HAART, while responders (R) had a positive outcome and were still alive. JCV DNA was extracted from cerebrospinal fluid biopsies and two regions of the genome were analysed, the transcriptional control region (TCR) and the major capsid protein gene (VP1). Both regions show different degrees of polymorphism and are recognized as evolving independently. Sequence analysis demonstrated that (i) extensive TCR rearrangements were present in both subgroups of patients, (ii) VP1 sequence polymorphisms could be identified in the BC loop, suggesting the absence of immune selection, and (iii) no genomic marker for JCV specific neurovirulence could be identified in the TCR and VP1 loci.

scholarly journals The Effect of Potent Antiretroviral Therapy and JC Virus Load in Cerebrospinal Fluid on Clinical Outcome of Patients with AIDS‐Associated Progressive Multifocal Leukoencephalopathy

2000 ◽  
Vol 182 (4) ◽  
pp. 1077-1083 ◽  
Author(s):  
Andrea De Luca ◽  
Maria Letizia Giancola ◽  
Adriana Ammassari ◽  
Susanna Grisetti ◽  
Maria Grazia Paglia ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Antiretroviral Therapy ◽  
Clinical Outcome ◽  
Progressive Multifocal Leukoencephalopathy ◽  
Jc Virus ◽  
Virus Load

scholarly journals Prognostic Value of JC Virus Load in Cerebrospinal Fluid of Patients with Progressive Multifocal Leukoencephalopathy

1998 ◽  
Vol 178 (6) ◽  
pp. 1816-1820 ◽  
Author(s):  
Yassine Taoufik ◽  
Jacques Gasnault ◽  
Amina Karaterki ◽  
Marie Pierre Ferey ◽  
Eric Marchadier ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Progressive Multifocal Leukoencephalopathy ◽  
Prognostic Value ◽  
Jc Virus ◽  
Virus Load

Analysis of the transcriptional control region in progressive multifocal leukoencephalopathy

2000 ◽  
Vol 6 (5) ◽  
pp. 398-409 ◽  
Author(s):  
Beatriz Vaz ◽  
Paola Cinque ◽  
Marcus Pickhardt ◽  
Thomas Weber
Keyword(s):  
Progressive Multifocal Leukoencephalopathy ◽  
Control Region ◽  
Transcriptional Control ◽  
Transcriptional Control Region
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