Involvement of the adrenal glands and testis in gap junction formation via testosterone within the male rat anterior pituitary gland

2012 ◽  
Vol 75 (12) ◽  
pp. 1632-1638 ◽  
Author(s):  
Eisuke Sakuma ◽  
Ikuo Wada ◽  
Takanobu Otsuka ◽  
Kenjiro Wakabayashi ◽  
Kinya Ito ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Gap Junction ◽  
Anterior Pituitary ◽  
Adrenal Glands ◽  
Anterior Pituitary Gland ◽  
Male Rat ◽  
Junction Formation

DISTRIBUTION OF MALE AND FEMALE STEROID SEX HORMONES IN SOME ORGANS OF THE MALE RAT

1970 ◽  
Vol 65 (1) ◽  
pp. 103-110 ◽  
Author(s):  
Kjell J. Tveter
Keyword(s):  
Skeletal Muscle ◽  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Liquid Scintillation ◽  
Specific Activity ◽  
Seminal Vesicles ◽  
Anterior Pituitary Gland ◽  
Male Rats ◽  
Male Rat ◽  
Accessory Sex Organs

ABSTRACT [6,7-3H] 17β-Oestradiol with a specific activity of 42.4 Ci/mmole was injected intramuscularly into three to four month old male rats, castrated three days previously. The radioactivity in liver, skeletal muscle, blood, the anterior pituitary gland, the seminal vesicles and in the different prostatic lobes was measured by liquid scintillation counting at different intervals after the administration. A high and prolonged uptake of radioactivity was found in the anterior pituitary gland. The uptake by the accessory sex organs was much lower, but significantly higher than that by skeletal muscle. The uptake by the prostate and the seminal vesicles in castrated animals was similar to that in non-castrated animals. The pattern of radioactivity uptake in the anterior pituitary gland of castrated male rats given [3H] testosterone was distinctly different from that after administration of [3H] 17β-oestradiol. There was a rapid elimination of radioactivity from the adenohypophysis after the administration of [3H] testosterone.

Sealing of the follicular lumen of the anterior pituitary gland of the male rat

1996 ◽  
Vol 28 (6) ◽  
pp. 631-635 ◽  
Author(s):  
Y. Mabuchi ◽  
H. Maruyama ◽  
T. Yashiro ◽  
S. Tanida ◽  
C. Kurono ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Anterior Pituitary Gland ◽  
Male Rat

The influence of adrenal hormone status on neuroendocrine peptides in the rat anterior pituitary gland

1990 ◽  
Vol 127 (3) ◽  
pp. 437-NP ◽  
Author(s):  
P. M. Jones ◽  
D. J. O'Halloran ◽  
M. A. Ghatei ◽  
J. Domin ◽  
S. R. Bloom
Keyword(s):  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Anterior Pituitary Gland ◽  
Male Rat ◽  
Mrna Levels ◽  
Adrenal Hormone ◽  
Rat Pituitary ◽  
Hormone Status ◽  
Anterior Pituitary Function ◽  
Wet Weight

ABSTRACT Neuropeptide Y (NPY), neurotensin (NT), substance P (SP) and vasoactive intestinal peptide (VIP) are four structurally unrelated neuroendocrine peptides which affect anterior pituitary function. All four peptides appear to be locally synthesized in the anterior pituitary gland and have been shown to be regulated by thyroid and/or sex hormone status. We show here that NT, SP and VIP but not NPY are influenced by adrenal hormone status in the male rat pituitary gland. Adrenalectomy increased the content of VIP (35·4±4·0 (s.e.m.) vs control 11·9±1·1 pmol/g wet weight) but decreased that of SP (18·8±2·3 vs control 36·7 ±3·9 pmol/g wet weight). Adrenalectomy combined with castration decreased the content of SP (14·6±3·5 vs control 36·7±3·9 pmol/g wet weight) but had no effect on VIP content. Treatment with dexamethasone produced significant decreases in NT, SP and VIP contents (17·8±2·3 vs control 32·6±3·4 pmol/g wet weight, 5·5±0·9 vs control 36·7±3·9 pmol/g wet weight and 4·2±0·6 vs control 11·9±1·1 pmol/g wet weight respectively). The changes in pituitary peptide contents occurred in parallel with changes in mRNA levels, suggesting that alterations in glucocorticoid hormone status can alter the synthesis of these peptides. These results, together with the known effects of these neuroendocrine peptides suggest possible functions for locally produced SP and VIP in regulating the secretion of adrenocorticotrophin and/or other proopiomelanocortin-derived peptides. The differential effects of adrenalectomy and adrenalectomy combined with castration on VIP suggests that the regulation of this pituitary peptide is complex, and may be dependent, in part at least, on gonadal factors. Journal of Endocrinology (1990) 127, 437–444

Ultrastructural evidence for oxytocin in the rat anterior pituitary gland

1988 ◽  
Vol 117 (3) ◽  
pp. 307-314 ◽  
Author(s):  
G. Morel ◽  
J.-G. Chabot ◽  
P. M. Dubois
Keyword(s):  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Secretory Granules ◽  
Immune Serum ◽  
Anterior Pituitary Gland ◽  
Male Rat ◽  
Posterior Lobe ◽  
Cytoplasmic Matrix ◽  
External Zone ◽  
Ultrathin Sections

Abstract. OT is synthetized in the hypothalamus. These neurons project to the posterior lobe of the pituitary and the external zone of the median eminence. In order to localize OT in the male rat anterior pituitary we have used immunocytochemistry on ultrathin sections in target cell(s) obtained by cryoultramicrotomy. OT-like immunoreactivity was observed in lactotropes only. No immunoreactivity was observed in gonadotropes, somatotropes, corticotropes or thyrotropes. In lactotropes, immunoreactivity was localized at the plasma membrane level, in the cytoplasmic matrix and around the secretory granules, but not in the other organelles, and in the nucleus. No reaction was observed by using either non-immune serum or anti-OT serum incubated with OT. No modification of OT-like immunoreactivity was observed by using antiOT serum incubated with heterologous peptides. These results 1) provide immunocytological evidence for the presence of OT in the anterior pituitary gland; 2) indicate the presence of this peptide in one particular cell type, and 3) support the hypothesis that OT could have a direct participation in the regulation of the PRL release.

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