Food Restriction Affects Inflammatory Response and Nutritional State in Tuco-tucos (Ctenomys talarum)

2016 ◽  
Vol 325 (10) ◽  
pp. 675-687 ◽  
Author(s):  
Julieta Leticia Merlo ◽  
Ana Paula Cutrera ◽  
Roxana Rita Zenuto
Keyword(s):  
Inflammatory Response ◽  
Food Restriction ◽  
Nutritional State ◽  
Ctenomys Talarum

scholarly journals Temporal changes in nutritional state affect hypothalamic POMC peptide levels independently of leptin in adult male mice

2014 ◽  
Vol 306 (8) ◽  
pp. E904-E915 ◽  
Author(s):  
Aaron J. Mercer ◽  
Ronald C. Stuart ◽  
Courtney A. Attard ◽  
Veronica Otero-Corchon ◽  
Eduardo A. Nillni ◽  
...  
Keyword(s):  
Energy Balance ◽  
Food Restriction ◽  
Fluorescent Protein ◽  
Negative Energy ◽  
Nutritional State ◽  
Melanocyte Stimulating Hormone ◽  
Reporter Mice ◽  
State Affect ◽  
Plasma Leptin ◽  
Chronic Food Restriction

Hypothalamic proopiomelanocortin (POMC) neurons constitute a critical anorexigenic node in the central nervous system (CNS) for maintaining energy balance. These neurons directly affect energy expenditure and feeding behavior by releasing bioactive neuropeptides but are also subject to signals directly related to nutritional state such as the adipokine leptin. To further investigate the interaction of diet and leptin on hypothalamic POMC peptide levels, we exposed 8- to 10-wk-old male POMC- Discosoma red fluorescent protein (DsRed) transgenic reporter mice to either 24–48 h (acute) or 2 wk (chronic) food restriction, high-fat diet (HFD), or leptin treatment. Using semiquantitative immunofluorescence and radioimmunoassays, we discovered that acute fasting and chronic food restriction decreased the levels of adrenocorticotropic hormone (ACTH), α-melanocyte-stimulating hormone (α-MSH), and β-endorphin in the hypothalamus, together with decreased DsRed fluorescence, compared with control ad libitum-fed mice. Furthermore, acute but not chronic HFD or leptin administration selectively increased α-MSH levels in POMC fibers and increased DsRed fluorescence in POMC cell bodies. HFD and leptin treatments comparably increased circulating leptin levels at both time points, suggesting that transcription of Pomc and synthesis of POMC peptide products are not modified in direct relation to the concentration of plasma leptin. Our findings indicate that negative energy balance persistently downregulated POMC peptide levels, and this phenomenon may be partially explained by decreased leptin levels, since these changes were blocked in fasted mice treated with leptin. In contrast, sustained elevation of plasma leptin by HFD or hormone supplementation did not significantly alter POMC peptide levels, indicating that enhanced leptin signaling does not chronically increase Pomc transcription and peptide synthesis.

Influence of preoperative nutritional state on inflammatory response after surgery

Nutrition ◽  
1999 ◽  
Vol 15 (11-12) ◽  
pp. 834-841 ◽  
Author(s):  
Kazuo Nakamura ◽  
Yukinori Moriyama ◽  
Hiroko Kariyazono ◽  
Nobuo Hamada ◽  
Hitoshi Toyohira ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Nutritional State

scholarly journals Older Age and Worse Nutritional State Were Related with Impaired Inflammatory Response in Elderly Patients

2016 ◽  
Vol 5 (2) ◽  
pp. 138
Author(s):  
Tuty Kuswardhani ◽  
Gede Sukrawan ◽  
Ketut Suastika
Keyword(s):  
Inflammatory Response ◽  
Elderly Patients ◽  
Older Age ◽  
Nutritional State

scholarly journals The effects of ω-3 fish oil emulsion-based parenteral nutrition plus combination treatment for acute paraquat poisoning

2018 ◽  
Vol 47 (2) ◽  
pp. 600-614
Author(s):  
Zhaohua Meng ◽  
Yanling Dong ◽  
Hengbo Gao ◽  
Dongqi Yao ◽  
Yu Gong ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Parenteral Nutrition ◽  
Fish Oil ◽  
Combination Treatment ◽  
Intervention Group ◽  
Nutritional State ◽  
Control Group ◽  
Oil Emulsion ◽  
Paraquat Poisoning ◽  
Baseline Levels

Objective To investigate the effects of parenteral nutrition (PN) including ω-3 fish-oil emulsion on nutritional state, inflammatory response, and prognosis in patients with acute paraquat poisoning. Methods Patients randomized to receive medium chain triglycerides (MCT)/long chain triglycerides (LCT)-based PN (control group) or MCT/LCT-based PN containing ω-3 fish-oil emulsion (intervention group) were compared for 90-day survival and short-term treatment efficacy. Results Tumour necrosis factor-α levels were significantly lower in the intervention group ( n = 101) versus controls ( n = 73) on treatment days 4 and 7. Intervention group C-reactive protein (CRP) levels were significantly increased on day 4, decreased to baseline (day 1) levels on day 7, and were significantly lower than baseline on day 10. Control group CRP levels were significantly increased on days 4 and 7 versus baseline, and returned to baseline levels on day 10. On day 7, retinol binding protein had recovered to baseline levels in the intervention group only. Intervention group mortality rate (36.6%) was significantly lower than controls (57.5%). ω-3 fish-oil PN was associated with reduced risk of death (hazard ratio 0.52; 95% confidence interval 0.33, 0.82). Conclusion In patients with acute paraquat poisoning, MCT/LCT with ω-3 fish-oil emulsion PN plus combination treatment advantageously attenuated the inflammatory response, modified the nutritional state, and was associated with significantly improved 90-day survival versus treatment without ω-3 fish oil.

Feeding behavior under predatory risk in Ctenomys talarum: nutritional state and recent experience of a predatory event

2018 ◽  
Vol 64 (2) ◽  
pp. 261-269 ◽  
Author(s):  
Valentina Brachetta ◽  
Cristian E. Schleich ◽  
Roxana R. Zenuto
Keyword(s):  
Feeding Behavior ◽  
Nutritional State ◽  
Recent Experience ◽  
Ctenomys Talarum

scholarly journals Individual condition and inflammatory response to PHA in the subterranean rodent Ctenomys talarum (Talas tuco-tuco): A multivariate approach

2018 ◽  
Vol 90 ◽  
pp. 47-54
Author(s):  
Julieta Leticia Merlo ◽  
Ana Paula Cutrera ◽  
Marcelo Javier Kittlein ◽  
Roxana Rita Zenuto
Keyword(s):  
Inflammatory Response ◽  
Multivariate Approach ◽  
Subterranean Rodent ◽  
Ctenomys Talarum ◽  
Individual Condition

Gut permeabillity and nitric oxide: Evidence for an endotoxin mediated inflammatory response in severe acute pancreatitis

2001 ◽  
Vol 120 (5) ◽  
pp. A468-A469
Author(s):  
S RAHMAN ◽  
B AMMORI ◽  
I MARTIN ◽  
G BARCLAY ◽  
M LARVIN ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acute Pancreatitis ◽  
Inflammatory Response ◽  
Severe Acute Pancreatitis

ERK and PKCξ independently contribute to the EPEC-induced inflammatory response

2001 ◽  
Vol 120 (5) ◽  
pp. A126-A126
Author(s):  
S SAVKOVIC ◽  
Z KAPADIA ◽  
A KOUTSOURIS ◽  
G HECHT
Keyword(s):  
Inflammatory Response
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