scholarly journals Fetal‐haemoglobin enhancing genotype at BCL11A reduces HbA 2 levels in patients with sickle cell anaemia

eJHaem ◽  
2021 ◽  
Author(s):  
Titilope A. Adeyemo ◽  
Oyesola O. Ojewunmi ◽  
Idayat Ajoke Oyetunji ◽  
Olufunto Olufela Kalejaiye ◽  
Stephan Menzel
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Fetal Haemoglobin

scholarly journals Mild sickle-cell anaemia in Iran associated with high levels of fetal haemoglobin.

1977 ◽  
Vol 14 (3) ◽  
pp. 168-171 ◽  
Author(s):  
M Haghshenass ◽  
F Ismail-Beigi ◽  
J B Clegg ◽  
D J Weatherall
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Fetal Haemoglobin

scholarly journals A survey of genetic fetal-haemoglobin modifiers in Nigerian patients with sickle cell anaemia

PLoS ONE ◽  
2018 ◽  
Vol 13 (6) ◽  
pp. e0197927 ◽  
Author(s):  
Titilope A. Adeyemo ◽  
Oyesola O. Ojewunmi ◽  
Idat A. Oyetunji ◽  
Helen Rooks ◽  
David C. Rees ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Fetal Haemoglobin

scholarly journals Effects of Glucose-6-Phosphate Dehydrogenase Deficiency upon Sickle Cell Anaemia

1989 ◽  
Vol 26 (6) ◽  
pp. 477-480 ◽  
Author(s):  
A K Al-Ali ◽  
M A M Ahmed ◽  
H Al-Idrissi ◽  
M H Al-Sibai ◽  
A R Al-Mutairy ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Dehydrogenase Deficiency ◽  
Glycated Haemoglobin ◽  
Survival Advantage ◽  
Fetal Haemoglobin ◽  
Significant Difference ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Normal Controls

The levels of glycated haemoglobin, fetal haemoglobin and methaemoglobin in 618 Saudi subjects were determined. A statistically significant decrease in the percentage of glycated haemoglobin was observed in all haemoglobinopathic groups studied in comparison to normal controls. However, there was no significant difference in the percentage of glycated haemoglobin in patients with sickle cell anaemia when compared with those sickle cell subjects who were also glucose-6-phosphate dehydrogenase deficient. This suggests that there is little survival advantage or disadvantage in the combination of glucose-6-phosphate dehydrogenase deficiency and sickle cell anaemia.

scholarly journals Fetal haemoglobin response to hydroxycarbamide treatment and sar1a promoter polymorphisms in sickle cell anaemia

2008 ◽  
Vol 141 (2) ◽  
pp. 254-259 ◽  
Author(s):  
Chutima Kumkhaek ◽  
James G. Taylor ◽  
Jianqiong Zhu ◽  
Carolyn Hoppe ◽  
Gregory J. Kato ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Promoter Polymorphisms ◽  
Fetal Haemoglobin

scholarly journals Correlating transcranial arterial Doppler velocities with haematologic parameters and haemolytic indices of Nigerian children with sickle cell anaemia

Ultrasound ◽  
2019 ◽  
Vol 27 (2) ◽  
pp. 101-110
Author(s):  
Anas Ismail ◽  
Aminu Abba Yusuf ◽  
Aisha Kuliya-Gwarzo ◽  
Sagir Gumel Ahmed ◽  
Abdulkadir Musa Tabari ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Sickle Cell ◽  
Cerebral Artery ◽  
Transcranial Doppler ◽  
Biochemical Markers ◽  
Sickle Cell Anaemia ◽  
Reticulocyte Count ◽  
Full Blood Count ◽  
Fetal Haemoglobin ◽  
Low Prevalence

Introduction Cerebral vasculopathy, elevated transcranial Doppler velocities and stroke are linked to excessive intravascular haemolysis in sickle cell anaemia. This study determined the prevalence and pattern of abnormal blood flow velocities in children with sickle cell anaemia from Northern Nigeria using transcranial Doppler and to correlate transcranial Doppler velocities with haematological and biochemical markers of haemolysis. Methods Full blood count, reticulocyte count, fetal haemoglobin and some selected biochemical markers of haemolysis of 100 children with sickle cell anaemia were determined at steady state. The time-averaged mean of maximal velocities in four major intracranial blood vessels was measured using non-imaging transcranial Doppler, which were then classified according to the stroke prevention in sickle cell disease trial protocol. A simple linear correlation between time-averaged mean of maximal velocities in the four major intracranial vessels as the dependent variable and haematological and biochemical markers of haemolysis as independent variables was also determined at the significance level of 0.05. Results Abnormal transcranial Doppler velocities, classified as high risk, were found in 3% of the studied patients; 11% had intermediate risk while 84% had standard risk. Most high velocities were detected in the middle cerebral artery. The time-averaged mean of maximal velocities of middle cerebral artery positively correlated with total white blood cell count, absolute neutrophil count, platelet count, reticulocyte count, serum lactate dehydrogenase and total bilirubin, while it was negatively correlated with haematocrit and fetal haemoglobin levels. Conclusion Our study showed low prevalence of abnormal transcranial Doppler velocities and low prevalence is unrelated to low markers of haemolysis in our study population.

Hypofibronectinaemia and severity of sickle cell anaemia in Nigeria

2000 ◽  
Vol 111 (4) ◽  
pp. 1194-1197 ◽  
Author(s):  
A. O. Emeribe ◽  
A. E. Udoh ◽  
M. H. Etukudoh ◽  
C. C. Okany ◽  
M. Kehinde ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia
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