One-pot Regioselective Synthesis of Novel 1-N-Methyl-spiro[2,3′]oxindole-spiro[3,3″]-1″-N-arylpyrrolidine-2″,5″-dione-4-arylpyrrolidines through Multicomponent 1,3-Dipolar Cycloaddition Reaction of Azomethine Ylide

2014 ◽  
Vol 52 (3) ◽  
pp. 827-833 ◽  
Author(s):  
Anjandeep Kaur ◽  
Manpreet Kaur ◽  
Baldev Singh
Keyword(s):  
Cycloaddition Reaction ◽  
Regioselective Synthesis ◽  
Azomethine Ylide ◽  
Dipolar Cycloaddition ◽  
One Pot

An efficient one pot regioselective synthesis of a 3,3′-spiro-phosphonylpyrazole-oxindole framework via base mediated [1,3]-dipolar cycloaddition reaction of the Bestmann–Ohira reagent with methyleneindolinones

2015 ◽  
Vol 13 (32) ◽  
pp. 8669-8675 ◽  
Author(s):  
Anil M. Shelke ◽  
Gurunath Suryavanshi
Keyword(s):  
Cycloaddition Reaction ◽  
Regioselective Synthesis ◽  
Dipolar Cycloaddition ◽  
One Pot

A one pot, highly regioselective synthesis of 3,3′-spiro-phosphonylpyrazole-oxindole by 1,3-dipolar cycloaddition of the Bestmann–Ohira reagent (BOR) & methyleneindolinones has been developed.

A convenient regioselective synthesis of spirooxindolinopyrrolizidines incorporating the pyrene moiety through a [3 + 2]-cycloaddition reaction

2017 ◽  
Vol 23 (5) ◽  
Author(s):  
Essam M. Hussein ◽  
Saleh A. Ahmed ◽  
Ismail I. Althagafi
Keyword(s):  
Cycloaddition Reaction ◽  
Regioselective Synthesis ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
One Pot Synthesis

AbstractA facile one-pot synthesis of spirooxindolinopyrrolizidines incorporating the pyrene moiety was accomplished in good yields through a 1,3-dipolar cycloaddition reaction of 3-aryl-1-(pyren-1-yl)prop-2-en-1-one derivatives with

One-pot highly diastereoselective synthesis of some novel spiro pyrrolizidines via 1,3-dipolar cycloaddition reaction of azomethine ylide

2004 ◽  
Vol 2004 (5) ◽  
pp. 347-349 ◽  
Author(s):  
Javad Azizian ◽  
R. Dastkhan ◽  
Ali A. Mohammadi ◽  
Mohammad R. Mohammadizadeh ◽  
Keyword(s):  
Cycloaddition Reaction ◽  
Azomethine Ylide ◽  
Dipolar Cycloaddition ◽  
Diastereoselective Synthesis ◽  
One Pot

scholarly journals [Bmim]Br Accelerated One-Pot Three-Component Cascade Protocol for the Construction of Spirooxindole–Pyrrolidine Heterocyclic Hybrids

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4779 ◽  
Author(s):  
Raju Suresh Kumar ◽  
Dhaifallah M. Al-thamili ◽  
Abdulrahman I. Almansour ◽  
Natarajan Arumugam ◽  
Necmi Dege
Keyword(s):  
Reaction Rate ◽  
Cycloaddition Reaction ◽  
Reaction Medium ◽  
Azomethine Ylide ◽  
Dipolar Cycloaddition ◽  
Synthetic Approach ◽  
One Pot ◽  
Short Reaction Time ◽  
Phenyl Alanine

Our synthetic approach for the assembly of structurally complex spirooxindole heterocyclic hybrids was based on an ionic liquid, [bmim]Br mediated one-pot three-component cascade reaction strategy involving 1,3-dipolar cycloaddition reaction of N-1-(2-pyridinylmethyl)-3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones and azomethine ylide generated in situ from isatin and L-phenyl alanine, affording a series of spirooxindole–pyrrolidine heterocyclic hybrids in good-to-excellent yields. In addition to serving as the reaction medium, [bmim]Br also functioned as a catalyst in this cycloaddition reaction and hence accelerated the reaction rate affording the cycloadducts in short reaction time.

Copper-catalyzed Convenient Synthesis and SAR Studies of Substituted-1,2,3-triazole as Antimicrobial Agents

2018 ◽  
Vol 16 (1) ◽  
pp. 3-10
Author(s):  
Aniket P. Sarkate ◽  
Kshipra S. Karnik ◽  
Pravin S. Wakte ◽  
Ajinkya P. Sarkate ◽  
Ashwini V. Izankar ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Agents ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Triazole Derivatives ◽  
Sar Studies ◽  
Convenient Synthesis ◽  
Antibacterial And Antifungal

Background:A novel copper-catalyzed synthesis of substituted-1,2,3-triazole derivatives has been developed and performed by Huisgen 1,3-dipolar cycloaddition reaction of azides with alkynes. The reaction is one-pot multicomponent.Objective:We state the advancement and execution of a methodology allowing for the synthesis of some new substituted 1,2,3-triazole analogues with antimicrobial activity.Methods:A series of triazole derivatives was synthesized by Huisgen 1,3-dipolar cycloaddition reaction of azides with alkynes. The structures of the synthesized compounds were elucidated and confirmed by 1H NMR, IR, MS and elemental analysis. All the synthesized compounds were tested for their antimicrobial activity against a series of strains of Bacillus subtilis, Staphylococcus aureus and Escherichia coli for antibacterial activity and against the strains of Candida albicans, Aspergillus flavus and Aspergillus nigar for antifungal activity, respectively.Results and Conclusion:From the antimicrobial data, it was observed that all the newly synthesized compounds showed good to moderate level of antibacterial and antifungal activity.

Rapid Access to Novel 1,2,3-Triazolo-Heterocyclic Scaffolds via Tandem Knoevenagel Condensation/Azide–Alkyne 1,3-Dipolar Cycloaddition Reaction in One Pot

2014 ◽  
Vol 16 (9) ◽  
pp. 466-477 ◽  
Author(s):  
Ram Awatar Maurya ◽  
Praveen Reddy Adiyala ◽  
D. Chandrasekhar ◽  
Chada Narsimha Reddy ◽  
Jeevak Sopanrao Kapure ◽  
...  
Keyword(s):  
Knoevenagel Condensation ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Rapid Access
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